Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tomoki Bo"'
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 152 (2024)
Bone marrow cells are the most sensitive to exposure to X-rays in the body and are selectively damaged even by doses that are generally considered permissive in other organs. Ascorbic acid (Asc) is a potent antioxidant that is reported to alleviate d
Externí odkaz:
https://doaj.org/article/12bafdf87f684e69a99f583999c65f13
Autor:
Tatsuya Deguchi, Kenji Hosoya, Shango Kim, Yusuke Murase, Kumiko Yamamoto, Tomoki Bo, Hironobu Yasui, Osamu Inanami, Mahiro Okumura
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 143-151 (2021)
Metformin has many anti-cancer effects, alone or in combination with radiation. However, the mechanism underlying its radio-sensitized effect is still unclear, especially for cancer stem-like cells (CSCs). Here, the radio-sensitized effect of metform
Externí odkaz:
https://doaj.org/article/12a605f119294206adcc769a6eac61c1
Autor:
Tomoki Bo, Sho Kobayashi, Osamu Inanami, Junichi Fujii, Osamu Nakajima, Tsunekata Ito, Hironobu Yasui
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101212- (2021)
L-type amino acid transporter 1 (LAT1) is important for transporting neutral amino acids into cells. LAT1 expression is correlated with cancer malignancy, suggesting that LAT1 is a promising target for cancer therapy. JPH203, a potential novel drug t
Externí odkaz:
https://doaj.org/article/2b874841681c4b269ee36071d16dabfa
Publikováno v:
Molecules, Vol 27, Iss 19, p 6187 (2022)
Ascorbate (vitamin C in primates) functions as a cofactor for a number of enzymatic reactions represented by prolyl hydroxylases and as an antioxidant due to its ability to donate electrons, which is mostly accomplished through non-enzymatic reaction
Externí odkaz:
https://doaj.org/article/f9df924a1af24a09a6c39298484b4528
Publikováno v:
Translational Oncology, Vol 10, Iss 4, Pp 491-500 (2017)
Checkpoint kinase 1 (Chk1) is an evolutionarily conserved serine/threonine kinase that plays an important role in G2/M checkpoint signaling. Here, we evaluate the radiosensitizing effects of a novel selective Chk1 inhibitor MK-8776, comparing its eff
Externí odkaz:
https://doaj.org/article/d7ba33c04db94279b3d6d698326303f0
Autor:
Shango Kim, Hironobu Yasui, Mahiro Okumura, Tatsuya Deguchi, Tomoki Bo, Osamu Inanami, Kenji Hosoya, Kumiko Yamamoto, Yusuke Murase
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss, Pp 143-151 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Metformin has many anti-cancer effects, alone or in combination with radiation. However, the mechanism underlying its radio-sensitized effect is still unclear, especially for cancer stem-like cells (CSCs). Here, the radio-sensitized effect of metform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd5dfa7ce81766fd61f6e96ceeda540
http://www.sciencedirect.com/science/article/pii/S2372770521001182
http://www.sciencedirect.com/science/article/pii/S2372770521001182
Autor:
Motofumi Suzuki, Kei Higashikawa, Osamu Inanami, Hironobu Yasui, Tomoki Bo, Tohru Shiga, Masaki Fujimoto, Yuki Shibata, Naoki Miyamoto, Yuji Kuge
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:821-833
Eribulin, an inhibitor of microtubule dynamics, is known to show antitumor effects through its remodeling activity in the tumor vasculature. However, the extent to which the improvement of tumor hypoxia by eribulin affects radio-sensitivity remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176112042e5bdc220386a2d4258cf2c9
https://doi.org/10.1007/s00259-021-05544-4
https://doi.org/10.1007/s00259-021-05544-4
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Mitotic catastrophe is a form of cell death linked to aberrant mitosis caused by improper or uncoordinated mitotic progression. Abnormal centrosome amplification and mitotic catastrophe occur simultaneously, and some cells with amplified centrosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abbd12d2f7bf27e0e30f52dc30a99d6
http://hdl.handle.net/2115/82881
http://hdl.handle.net/2115/82881
Publikováno v:
Biochemical and Biophysical Research Communications. 522:144-150
Mitochondrial dynamics are crucial for cellular survival in response to various stresses. Previously, we reported that Drp1 promoted mitochondrial fission after x-irradiation and its inhibition resulted in reduced cellular radiosensitivity and mitoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6719071d84d6d40bc29e7ff09d208ad3
https://doi.org/10.1016/j.bbrc.2019.11.027
https://doi.org/10.1016/j.bbrc.2019.11.027
Autor:
Tomoki, Bo, Hironobu, Yasui, Tohru, Shiga, Yuki, Shibata, Masaki, Fujimoto, Motofumi, Suzuki, Kei, Higashikawa, Naoki, Miyamoto, Osamu, Inanami, Yuji, Kuge
Publikováno v:
European journal of nuclear medicine and molecular imaging. 49(3)
Eribulin, an inhibitor of microtubule dynamics, is known to show antitumor effects through its remodeling activity in the tumor vasculature. However, the extent to which the improvement of tumor hypoxia by eribulin affects radio-sensitivity remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e37ad2001bb5b80741b65c1aa02392e
https://pubmed.ncbi.nlm.nih.gov/34468781
https://pubmed.ncbi.nlm.nih.gov/34468781