Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Tomoki, Kuwahara"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108893- (2024)
Summary: α-Synuclein and LRRK2 are associated with both familial and sporadic Parkinson’s disease (PD), although the mechanistic link between these two proteins has remained elusive. Treating cells with lysosomotropic drugs causes the recruitment
Externí odkaz:
https://doaj.org/article/2dc29bb247bc4fb6b0e29398efefee35
Autor:
Tadayuki Komori, Tomoki Kuwahara
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1645 (2023)
Over the last decades, research on the pathobiology of neurodegenerative diseases has greatly evolved, revealing potential targets and mechanisms linked to their pathogenesis. Parkinson’s disease (PD) is no exception, and recent studies point to th
Externí odkaz:
https://doaj.org/article/0ece8b09ffe548ac9d162fb91453c4c3
Autor:
Tetsuro Abe, Tomoki Kuwahara
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Previous genetic studies on hereditary Parkinson's disease (PD) have identified a set of pathogenic gene mutations that have strong impacts on the pathogenicity of PD. In addition, genome-wide association studies (GWAS) targeted to sporadic PD have n
Externí odkaz:
https://doaj.org/article/b8c3b101b5b6403a92e29c9b8e1447dc
Autor:
Tomoki Kuwahara, Kai Funakawa, Tadayuki Komori, Maria Sakurai, Gen Yoshii, Tomoya Eguchi, Mitsunori Fukuda, Takeshi Iwatsubo
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105081- (2020)
Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson's disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate
Externí odkaz:
https://doaj.org/article/d3f3e8da07684b209cf729edfe003571
Autor:
Tomoki Kuwahara, Takeshi Iwatsubo
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The leucine-rich repeat kinase 2 (LRRK2), the most common causative gene for autosomal-dominant familial Parkinson’s disease, encodes a large protein kinase harboring multiple characteristic domains. LRRK2 phosphorylates a set of Rab GTPases in cel
Externí odkaz:
https://doaj.org/article/b8ed307bf2bb41998ba050792bd9968b
Autor:
Yuki Tanaka, Kaoru Yamada, Kyoko Satake, Itaru Nishida, Matthias Heuberger, Tomoki Kuwahara, Takeshi Iwatsubo
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The pathological aggregation of tau characterizes a set of neurodegenerative diseases collectively referred to as tauopathies. Recent studies using cellular and animal models have suggested that tau pathology progresses by trans-cellular propagation.
Externí odkaz:
https://doaj.org/article/a05c75f132f34395b9a156504eda7172
Rab proteins are small GTPases that regulate a myriad of intracellular membrane trafficking events. Rab29 is one of the Rab proteins phosphorylated by leucine-rich repeat kinase 2 (LRRK2), a Parkinson’s disease-associated kinase. Recent studies sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3a2b242b499824b36c074a4d29f5ef
https://doi.org/10.1101/2022.09.26.509472
https://doi.org/10.1101/2022.09.26.509472
Autor:
Tadayuki Komori, Tomoki Kuwahara, Tetta Fujimoto, Sakurai, Maria, Ikuko Koyama-Honda, Mitsunori Fukuda, Takeshi Iwatsubo
Publikováno v:
Journal of Cell Science; Jul2023, Vol. 136 Issue 14, p1-13, 13p
Autor:
Mizuki Watanabe, Patricia Dranchak, Satoshi Shuto, Takafumi Yoshikane, Hiroaki Suga, Rika Okuma, James Inglese, Tomoki Kuwahara, Yuki Goto
Publikováno v:
Chem Asian J
Here we report the construction of an mRNA-encoded library of thioether-closed macrocyclic peptides by using an N-chloroacetyl-cyclopropane-containing exotic initiator whose structure is more constrained than the ordinary N-chloroacetyl-α-amino acid