Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Tomoki, Chiba"'
Autor:
Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara
Publikováno v:
Regenerative Therapy, Vol 25, Iss , Pp 186-193 (2024)
Introduction: The periodontium is a connective tissue which consists of periodontal ligament, alveolar bone, cementum and gingiva. Periodontal ligament (PDL) is a specialized connective tissue that connects the cementum – coating the surface of the
Externí odkaz:
https://doaj.org/article/49f2944770544efea24f15a2fba82873
Autor:
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Sasako et al. show that disruption of the insulin/IGF-1 signaling by suppressing Akt activity in mouse skeletal muscle can accelerate osteosarcopenia and shortens lifespan, which is reversed by inactivation of FoxOs rather than activation of mTOR, su
Externí odkaz:
https://doaj.org/article/485f04e2a5324e6780b6abc02a8a35ba
Autor:
Sarasa Yano, Kaito Akiyama, Rio Tsuchiya, Hikari Kubotani, Tomoki Chiba, Takeshi Nagata, Fuminori Tsuruta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The micronucleus is known to be a biomarker for genomic instability, which is a hallmark of tumors and aging. Normally, micronuclei are produced by segregation errors and mechanical stresses arising from dividing or migrating cells, leading
Externí odkaz:
https://doaj.org/article/692244364ba24204a0d4329f4880b541
Autor:
Ban Sato, Jiwoo Kim, Kazunori Morohoshi, Woojin Kang, Kenji Miyado, Fuminori Tsuruta, Natsuko Kawano, Tomoki Chiba
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 586 (2023)
Proteasomes are highly sophisticated protease complexes that degrade non-lysosomal proteins, and their proper regulation ensures various biological functions such as spermatogenesis. The proteasome-associated proteins, PA200 and ECPAS, are predicted
Externí odkaz:
https://doaj.org/article/c5bdbc48f5204a8189df3ab2b4ca22d6
Autor:
Kaho Takada, Tomoki Chiba, Takayuki Miyazaki, Lisa Yagasaki, Ryo Nakamichi, Takanori Iwata, Keiji Moriyama, Hiroyuki Harada, Hiroshi Asahara
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The periodontal ligament (PDL) comprises a fibrous tissue that connects teeth to alveolar bone and is essential for periodontal function. The transcription factor mohawk homeobox (Mkx) is expressed in the PDL where it plays an important role in the d
Externí odkaz:
https://doaj.org/article/c15c64b8d7d54ef99477e2dc4a9bf5c7
Autor:
Hiroki Tsutsumi, Ryota Kurimoto, Ryo Nakamichi, Tomoki Chiba, Takahide Matsushima, Yuta Fujii, Risa Sanada, Tomomi Kato, Kana Shishido, Yuriko Sakamaki, Tsuyoshi Kimura, Akio Kishida, Hiroshi Asahara
Publikováno v:
Journal of Tissue Engineering, Vol 13 (2022)
Tendons and ligaments are essential connective tissues that connect the muscle and bone. Their recovery from injuries is known to be poor, highlighting the crucial need for an effective therapy. A few reports have described the development of artific
Externí odkaz:
https://doaj.org/article/8a19bcd27337489aa78fffa7de09e233
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6316 (2022)
Healthy limb joints are important for maintaining health and attaining longevity. Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal development) is essential for bone formation, especially in long-axis bones
Externí odkaz:
https://doaj.org/article/cd25220b93c543d78717489ae4447e1c
Autor:
Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara
Publikováno v:
FEBS Letters. 597:975-984
Autor:
Kensuke Kataoka, Ryota Kurimoto, Hiroki Tsutsumi, Tomoki Chiba, Tomomi Kato, Kana Shishido, Mariko Kato, Yoshiaki Ito, Yuichiro Cho, Osamu Hoshi, Ayako Mimata, Yuriko Sakamaki, Ryo Nakamichi, Martin K. Lotz, Keiji Naruse, Hiroshi Asahara
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Tendons and ligaments are pivotal connective tissues that tightly connect muscle and bone. In this study, we developed a novel approach to generate tendon/ligament-like tissues with a hierarchical structure, by introducing the tendon/ligament-specifi
Externí odkaz:
https://doaj.org/article/20e44cb8d8ce4a15883916e45a651b9d
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Since human and mouse Y chromosomes contain repeated sequences, it is difficult to determine the precise sequences and analyze the function of individual Y chromosome genes. Therefore, the causes of many diseases and abnormalities related to Y chromo
Externí odkaz:
https://doaj.org/article/a833b07f12a345e8b77b01f3e6dfbbe9