Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tomokazu Ohnuma"'
Autor:
Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka, Tadashi Izawa, Yasuhiro Masuda, Tomokazu Ohnuma
Publikováno v:
Fundamental Toxicological Sciences. 6:107-112
Autor:
Akira Hiratsuka, Kenichiro Ogura, Yasuhiro Masuda, Tomokazu Ohnuma, Takahito Nishiyama, Tadashi Izawa
Publikováno v:
The Journal of toxicological sciences. 44(11)
Magnoliae Cortex contains a range of bioactive components including terpenes (e.g. α-, β- and γ-eudesmol), phenylpropanoids (e.g. honokiol and magnolol) and alkaloids (e.g. magnocurarine). We recently reported that pretreatment of PC12 cells with
Autor:
Takahito, Nishiyama, Nahoko, Hayashi, Hiromi, Yanagita, Tomokazu, Ohnuma, Kenichiro, Ogura, Akira, Hiratsuka
Publikováno v:
The Journal of toxicological sciences. 44(10)
Cigarette smoking is a risk factor for the development of various cancers, such as lung, nasal, liver and bladder cancers. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, is implicated in human lung cancer. NNK-i
Autor:
Akira Hiratsuka, Takahito Nishiyama, Kenichiro Ogura, Shin Saito, Mai Shimoda, Eri Anzai, Yohei Suzuki, Tomokazu Ohnuma
Publikováno v:
Archives of Biochemistry and Biophysics. 585:17-24
Nuclear factor-E2-related factor 2 (Nrf2) is an important transcription factor and plays a central role in inducible expression of many cytoprotective genes. Recent studies have reported that various cancer cells having unrestrained Nrf2 due to its o
Autor:
Tomokazu Ohnuma, Chiaki Takagi, Kenichiro Ogura, Kazuya Sakamoto, Takahito Nishiyama, Shoko Ohno, Akira Hiratsuka, Asumi Shinoda
Publikováno v:
Archives of biochemistry and biophysics. 635
Many lines of evidence demonstrate that transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays essential roles in cancer cell proliferation and resistance to chemotherapy, thereby indicating that suppression of abnormal Nrf2 activation
Autor:
Naoki Kakurai, Akira Hiratsuka, Nahoko Hayashi, Takahito Nishiyama, Ai Kuriyama, Chika Miyamoto, Tomokazu Ohnuma, Hiromi Yanagita, Yumi Ishihara, Kenichiro Ogura
Publikováno v:
The Journal of Toxicological Sciences. 39:515-521
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induced lung tumors in rodents and is likely involved in human lung cancer. 4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (HO-methyl NNK) glucuronide, a glu
Autor:
Akira Hiratsuka, Takahito Nishiyama, Takashi Matsumoto, Kenichiro Ogura, Tomokazu Ohnuma, Ayako Kawana, Ayano Itoi
Publikováno v:
Biochemical and Biophysical Research Communications. 413:623-629
Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor because Nrf2-regulated enzymes play a key role in antioxidant and detoxification processes. Recent studies have reported that lung cancer cells overexpressi
Autor:
Takahito Nishiyama, Tomokazu Ohnuma, Rika Hoashi, Yuika Takeda, Kenichiro Ogura, Akira Hiratsuka, Eisaburo Anan
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:371-378
Falcarindiol is a diacetylenic natural product containing unique carbon-carbon triple bonds. Mice were orally administrated falcarindiol (100 mg/kg), and drug-metabolizing and antioxidant enzymes were monitored in several tissues of mice. Treatment w
Autor:
Yasuhiro Masuda, Miki Fujishima, Akira Hiratsuka, Tomokazu Ohnuma, Takahito Nishiyama, Tadashi Izawa, Kenichiro Ogura
Publikováno v:
Archives of Biochemistry and Biophysics. 478:75-80
Phenylbutazone (PB) is known to be biotransformed to its O- and C-glucuronide. Recently, we reported that PB C-glucuronide formation is catalyzed by UGT1A9. Interestingly, despite UGT1A8 sharing high amino acid sequence identity with UGT1A9, UGT1A8 h
Autor:
Tomokazu Ohnuma, Takahito Nishiyama, Kenichiro Ogura, Takehiko Kishi, Yuu Inoue, Akira Hiratsuka
Publikováno v:
Biochemical and Biophysical Research Communications. 371:247-250
Menadione (2-methyl-1,4-naphthoquine), also known as vitamin K3, has been widely used as a model compound in the field of oxidative stress-related research. The metabolism of menadione has been studied, and it is known that menadione undergoes a two-