Výsledky vyhledávání - "Tomokazu Matsusue"

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

Autor: Takaho Terada, Alexander A. Tokmakov, Takako Fujimoto, Mutsuko Kukimoto-Niino, Masaki Kawamoto, Tomokazu Matsusue, Mikako Shirouzu, Ikuya Shiromizu, Shigeyuki Yokoyama, Naomi Ohbayashi, Sumiko Gomi

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 67:763-773

The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA. PDC activity is tightly regulated by four members of a family of pyruvate dehydrogenase kinase isoforms (PDK1-4), which phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c49457722f6c968681b57b22d097de
https://doi.org/10.1107/s090744491102405x

Zobrazit plný text záznamu

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors VI. A Series of New Derivatives Containing N,S- and N,SO2-Spiro Acetal Scaffolds

Autor: Fumihiko Saitoh, Hidemitsu Nishida, Yoshitaka Hosaka, Munetaka Ohkouchi, Naoto Kosuga, Ikuya Shiromizu, Tomokazu Matsusue, Ichiro Yamamoto, Miwa Matsumoto, Takafumi Mukaihira

Publikováno v: Chemical and Pharmaceutical Bulletin. 55:317-323

In the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b781fed7c810a4e565ae830ee7f451b
https://doi.org/10.1248/cpb.55.317

Zobrazit plný text záznamu

Pharmacological characterization of the active synthetic factor Xa inhibitors M55551 and M55165

Autor: Masatsugu Kamiya, Hidemistu Nishida, Mikihiko Shinozaki, Hidemi Ishii, Tamami Ohno, Tomokazu Matsusue, Yukiko Yatagai, Miwa Matsumoto, Kiyoshi Mizuguchi, Misao Kurokawa, Yoshitaka Hosaka

Publikováno v: European Journal of Pharmacology. 529:164-171

Factor Xa plays an important role in blood coagulation and is widely regarded as an attractive target for antithrombotic drug development. M55551 and M55165 (1-arylsulfonyl-3-piperazinone derivatives) are novel synthetic factor Xa inhibitors. In vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8a14ecebb912af239117277ef92b80
https://doi.org/10.1016/j.ejphar.2005.11.002

Zobrazit plný text záznamu

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition

Autor: Fumihiko Saitoh, Hidenori Mochizuki, Atsushi Okamoto, Hidemitsu Nishida, Yoshitaka Hosaka, Hiroyasu Shimada, Tomokazu Matsusue, Yutaka Miyazaki, Takafumi Mukaihira, Kazuhiro Suzuki, Masashi Mizuno, Miwa Matsumoto, Shuhei Ohnishi

Publikováno v: Chemical and Pharmaceutical Bulletin. 52:459-462

Compounds containing an ethylenediamine structure in place of the piperazine ring of M55113 (1) and M55551 (2) were synthesized to investigate the effects of a piperazine moiety and evaluated for activity as factor Xa (FXa) inhibitors. Most such comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96901fe22bd499b167748b2c8c5337a9
https://doi.org/10.1248/cpb.52.459

Zobrazit plný text záznamu

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor. II. Substituent Effect on Biological Activities

Autor: Hidemitsu Nishida, Yoshitaka Hosaka, Harada Kousuke, Manabu Itoh, Aki Muraoka, Hidenori Mochizuki, Tomokazu Matsusue, Fumihiko Saitoh, Miwa Matsumoto, Miyuki Fukui, Shuhei Ohnishi, Atsushi Okamoto, Takafumi Mukaihira, Yutaka Miyazaki

Publikováno v: Chemical and Pharmaceutical Bulletin. 50:1187-1194

Intravascular clot formation is an important event in a number of cardiovascular diseases. The prevention of blood coagulation has become a major target for new therapeutic agents. Factor Xa (FXa) is a trypsin-like serine protease that plays a key ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bc367a4c2a5079d0ff7aa49a511ecc
https://doi.org/10.1248/cpb.50.1187

Zobrazit plný text záznamu

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitor

Autor: Yutaka Miyazaki, Hidemitsu Nishida, Masayuki Ohashi, Hidenori Mochizuki, Yoshihiro Kitamura, Tomokazu Matsusue, Yoshitaka Hosaka, Atsushi Okamoto, Shuhei Ohnishi

Publikováno v: Chemical and Pharmaceutical Bulletin. 49:1237-1244

Intravascular clot formation is an important factor in a number of cardiovascular diseases. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2a6fe96d3ae38b0e0f2bc8fa83c99b
https://doi.org/10.1248/cpb.49.1237

Zobrazit plný text záznamu

Design of Variants of the Second Domain of Urinary Trypsin Inhibitor (R-020) with Increased Factor Xa Inhibitory Activity

Autor: Keisuke Sugihara, Hideaki Morishita, Toshinori Kanamori, Hideaki Umeyama, Jiro Hirose, Mitsuko Isaji, Tomokazu Matsusue, Toshihisa Miura, Yoshifumi Horisawa, Toru Yamakawa, Atsushi Nii

Publikováno v: The Journal of Biochemistry. 115:1107-1112

The second domain (R-020) of human urinary trypsin inhibitor (UTI) exerts similar inhibitory activities on trypsin, alpha-chymotrypsin, leukocyte elastase, and plasmin to those of UTI itself, and additionally inhibits coagulation factor Xa (FXa) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76304e22cde7eebe4e2ec24e77aa8650
https://doi.org/10.1093/oxfordjournals.jbchem.a124465

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitor

Autor: Hidemitsu Nishida, Yutaka Miyazaki, Masayuki Ohashi, Atsushi Okamoto, Yoshitaka Hosaka, Yoshihiro Kitamura, Hidenori Mochizuki, Tomokazu Matsusue, Shuhei Ohnishi

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3fb88045455f9a0855aa97b5f44934a
https://doi.org/10.1002/chin.200212265

Zobrazit plný text záznamu

Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo

Autor: Junken Aoki, Nozomu Kono, Hiroyuki Sato, Hiroyuki Arai, Etsuo Niki, Tomokazu Matsusue, Yasukazu Yoshida, Takao Inoue, Hiroyuki Itabe

Publikováno v: The Journal of biological chemistry. 283(3)

Membrane phospholipids are susceptible to oxidation, which is involved in various pathological processes such as inflammation, atherogenesis, neurodegeneration, and aging. One enzyme that may help to remove oxidized phospholipids from cells is intrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1a5185a0be6b2f4a9570d95f700c02
https://pubmed.ncbi.nlm.nih.gov/18024956

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání