Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Tomokazu Hosokawa"'
Autor:
Seiji Nagumo, Maemi Suzuki, Takayuki Matsumoto, Yohei Sasaki, Katsuo Kamata, Tsuneo Kobayashi, Tomokazu Hosokawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1555-1560
We investigated the vasorelaxant activity of the methanolic extracts of Sappan Lignum (CSE) and its constituents, brazilin, sappanchalcone, and protosappanins A-E, on rat aorta and mesenteric artery. By comparing the vasorelaxant activity of CSE and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc8cda43321e38a3cf5e7980987a9c5
https://doi.org/10.1248/bpb.33.1555
https://doi.org/10.1248/bpb.33.1555
Publikováno v:
Biological and Pharmaceutical Bulletin. 32:941-944
We performed an in vitro assay for seven compounds from methanolic extract of Sappan Lignum (CSE) that inhibit the chemical mediators of inflammation using the J774.1 cell line: brazilin (1), sappanchalcone (2), protosappanin A (3), protosappanin B (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6758c52256262e8905462b66c018b36e
https://doi.org/10.1248/bpb.32.941
https://doi.org/10.1248/bpb.32.941
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:193-196
In the course of our screening, we found that the methanolic extract of Sappan Lignum showed strong activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production by macrophages in vitro. As it was reported that Brazilin inhibited ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a0951e78b1c6f49dd0df910a8667fc
https://doi.org/10.1248/bpb.30.193
https://doi.org/10.1248/bpb.30.193
Autor:
Tomokazu Hosokawa
Publikováno v:
Folia Pharmacologica Japonica. 111:243-248
Airway hyperreactivity (AHR) is an important characteristic feature of asthma. Recently, it has been recognized that airway inflammation underlies the phenomenon of AHR. Kinins such as bradykinin (BK) and kallidin (KD) have been implicated as mediato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae51b47b3eac9817a4219e4686451e34
https://doi.org/10.1254/fpj.111.243
https://doi.org/10.1254/fpj.111.243
Publikováno v:
Japanese Journal of Pharmacology. 52:639-642
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbec3577e9349713d310ade014807075
https://doi.org/10.1016/s0021-5198(19)40024-3
https://doi.org/10.1016/s0021-5198(19)40024-3
Publikováno v:
Journal of Pharmacobio-Dynamics. 13:30-35
The effects of clonidine on the vagal reflex-induced tracheal constriction have been investigated in anesthetized, paralyzed, and artificially ventilated mongrel dogs. The cervical trachea was transected in situ into two parts. Responses of the trach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc280a9357a117e98b4e2405209a4f0
https://doi.org/10.1248/bpb1978.13.30
https://doi.org/10.1248/bpb1978.13.30
Publikováno v:
Japanese Journal of Pharmacology. 53:506-509
Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bbf330e2609b1151ea68fd1a80e833
https://doi.org/10.1254/jjp.53.506
https://doi.org/10.1254/jjp.53.506
Publikováno v:
Japanese Journal of Pharmacology. 53:301-309
The effect of ouabain on the cholinergic neurotransmission of the trachea was investigated using isolated tracheal strips in dogs. Tracheal strips without epithelium were suspended in organ chambers filled with modified Krebs-Henseleit solution. Ouab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26602af3649c3935359b973d7118e7fb
https://doi.org/10.1254/jjp.53.301
https://doi.org/10.1254/jjp.53.301
Autor:
Takehiro Uchibori, Kazuki Endo, Kentaro Kogi, Takashi Konno, Norimichi Nakahata, Akihiko Nagai, Kazuhiro Uemoto, Tomokazu Hosokawa, Shinya Ohnuma
Publikováno v:
European journal of pharmacology. 486(3)
We evaluated the activities of 2-alkynyladenosine derivatives, relatively selective adenosine A2 receptor agonists, in the intraocular pressure regulation in rabbits. An adenosine A2 receptor agonist 2-[p-(2-carboxyethyl)phenylethylamino]-5′-N-ethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640e10d6ad9759638117d529fec029a3
https://pubmed.ncbi.nlm.nih.gov/14985053
https://pubmed.ncbi.nlm.nih.gov/14985053
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:1243-1245
Effects of the R(+)- and S(−)-isomers of befunolol and carteolol, β-adrenoceptors with intrinsic sympathomimetic activity, on the rabbit intraocular pressure were tested. The intraocular pressure was decreased by instillation of the R(+)- and S(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220a010f84b8a3657d0656745d29e719
https://doi.org/10.1139/y91-182
https://doi.org/10.1139/y91-182