Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tomoka Igata"'
Autor:
Tomoka Igata, Hiroshi Tanaka, Kan Etoh, Seonghyeon Hong, Naoki Tani, Tomoaki Koga, Mitsuyoshi Nakao
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262488 (2022)
Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SE
Externí odkaz:
https://doaj.org/article/5180f5d780a54889947538e4cec12706
Autor:
Hiroshi Tanaka, Shin-ichiro Takebayashi, Akihisa Sakamoto, Tomoka Igata, Yuko Nakatsu, Noriko Saitoh, Shinjiro Hino, Mitsuyoshi Nakao
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2148-2161 (2017)
Summary: Cellular senescence is an irreversible growth arrest that contributes to development, tumor suppression, and age-related conditions. Senescent cells show active metabolism compared with proliferating cells, but the underlying mechanisms rema
Externí odkaz:
https://doaj.org/article/19dbff3eeaf547fc9ad3a9db67131595
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling
Autor:
Mitsuyoshi Nakao, Hiroshi Tanaka, Shin-ichiro Takebayashi, Tomoaki Koga, Tomoka Igata, Kan Etoh
Publikováno v:
Aging Cell
Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET meth
Autor:
Akihisa Sakamoto, Shin-ichiro Takebayashi, Noriko Saitoh, Yuko Nakatsu, Tomoka Igata, Hiroshi Tanaka, Shinjiro Hino, Mitsuyoshi Nakao
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2148-2161 (2017)
Summary: Cellular senescence is an irreversible growth arrest that contributes to development, tumor suppression, and age-related conditions. Senescent cells show active metabolism compared with proliferating cells, but the underlying mechanisms rema
Autor:
Shin-ichiro Takebayashi, Akihisa Sakamoto, Masashi Narita, Yuko Nakatsu, Tomoka Igata, Hiroshi Tanaka, Shinjiro Hino, Mitsuyoshi Nakao
Publikováno v:
Aging Cell
Metabolism is closely linked with cellular state and biological processes, but the mechanisms controlling metabolic properties in different contexts remain unclear. Cellular senescence is an irreversible growth arrest induced by various stresses, whi