Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Tomoka Gose"'
1
Akademický článek
The role of ATP-binding Cassette subfamily B member 6 in the inner ear
Autor: Stefanie A. Baril, Katie A. Wilson, Md Munan Shaik, Yu Fukuda, Robyn A. Umans, Alessandro Barbieri, John Lynch, Tomoka Gose, Alexander Myasnikov, Michael L. Oldham, Yao Wang, Jingwen Zhu, Jie Fang, Jian Zuo, Ravi C. Kalathur, Robert C. Ford, Allison Coffin, Michael R. Taylor, Megan L. O’Mara, John D. Schuetz
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract ABCB6 has been implicated in dyschromatosis universalis hereditaria, a condition characterized by hyperpigmented and hypopigmented skin macules. Dyschromatosis universalis hereditaria can also present with hearing loss. Dyschromatosis univer
Externí odkaz: https://doaj.org/article/4b2b8dd9b6f64e83a7c32805ca68bbac
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3
Akademický článek
The net electrostatic potential and hydration of ABCG2 affect substrate transport
Autor: Tomoka Gose, Heather M. Aitken, Yao Wang, John Lynch, Evadnie Rampersaud, Yu Fukuda, Medb Wills, Stefanie A. Baril, Robert C. Ford, Anang Shelat, Megan L. O’Mara, John D. Schuetz
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular accumulation of chemotherapeutic drugs to facilitate multidru
Externí odkaz: https://doaj.org/article/0de3acd6f4884042a8d4c3ec9400e788
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5
Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment
Autor: Juwina Wijaya, John D. Schuetz, Tomoka Gose
Publikováno v: Pharmacol Rev
Eliminating cancer was once thought of as a war. This analogy is still apt today; however, we now realize that cancer is a much more formidable enemy than scientists originally perceived, and in some cases, it harbors a profound ability to thwart our
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7db66a91e84da4c493b381b5ab815
https://doi.org/10.1124/pr.118.016824
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6
ABCG2 requires a single aromatic amino acid to 'clamp' substrates and inhibitors into the binding pocket
Autor: John Lynch, Alice Allcock, Taosheng Chen, Ikumi Tamai, Robert C. Ford, John D. Schuetz, Tomoka Gose, Yao Wang, Ailsa Gavan McHarg, Anang A. Shelat, Yu Fukuda, Sourav Das, Talha Shafi
Publikováno v: FASEB J
ATP-binding cassette sub-family G member 2 (ABCG2) is a homodimeric ATP-binding cassette (ABC) transporter that not only has a key role in helping cancer cells to evade the cytotoxic effects of chemotherapy, but also in protecting organisms from mult
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96c1956c0eacb2e29257c6e37f55dbc
https://doi.org/10.1096/fj.201902338rr
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7
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1
Autor: Shunsuke Kamo, Ikumi Tamai, Yoshinobu Nakamura, Tomoka Gose, Rika Aotani, Takeo Nakanishi
Publikováno v: Journal of Pharmaceutical Sciences. 106:2483-2490
To understand interaction of drugs with the prostaglandin transporter OATP2A1/SLCO2A1 that regulates disposition of prostaglandins, we explored the impact of 636 drugs in an FDA-approved drug library on 6-carboxyfluorescein (6-CF) uptake by OATP2A1-e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4702521520d326182b6c2bd833bb8142
https://doi.org/10.1016/j.xphs.2017.04.046
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