Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tomoji Kawabata"'
Autor:
Takeshi Shiota, Tomoji Kawabata, Mitsugu Kiyokawa, Tsunetoshi Honma, Masafumi Fujimoto, Teruo Yamamori, Masayoshi Ogawa, Natsuki Ishizuka, Katsunori Sakai, Kunio Hayashi, Mariko Hara, Ken-ichi Matsumura, Shigeyuki Nakajima
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:928-938
We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4b5a1bdb93bc4abdba324d44af2208
https://doi.org/10.1248/cpb.47.928
https://doi.org/10.1248/cpb.47.928
Autor:
Mariko Hara, Tomoji Kawabata, Kunio Hayashi, Masaru Kawakami, Shigeyuki Nakajima, Ryuichi Kiyama, Masafumi Fujimoto, Toshio Fujishita
Publikováno v:
ChemInform. 26
A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-alpha]pyrimidine-3-carboxyli c acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an in vitro binding assay using COS cells transfected with a cDNA enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da6b81c64851b8d90c88e41cd12efcf
https://doi.org/10.1002/chin.199548171
https://doi.org/10.1002/chin.199548171
Publikováno v:
FEBS Letters. 309:185-189
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have different C-terminal tail structures compared with the rather conservative ring structures which consist of 17 amino acid residues. To examine the different effects of the tail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7d0d5d30e7ef8a1edd6d8e898fbecc
https://doi.org/10.1016/0014-5793(92)81091-y
https://doi.org/10.1016/0014-5793(92)81091-y
Publikováno v:
Drug Development Research. 19:23-36
S-8666, a newly developed antihypertensive uricosuric diuretic, possesses an asymmetric carbon and exists as a racemic mixture. The enantioselectivity of S-8666 in natriuresis and the renal excretory mechanisms of the S-8666 enantiomers were examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e8dd74321b1d03d3367cd1eb92a0c9
https://doi.org/10.1002/ddr.430190104
https://doi.org/10.1002/ddr.430190104
Autor:
Tomoji Kawabata, Azumi Ueyama, Shuuichi Matsushima, Toshikatsu Shimizu, Morio Nagira, Mikinori Torii, Akinori Arimura, Hisashi Oku, Ichiro Hikita
Publikováno v:
European journal of pharmacology. 590(1-3)
Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic disease models, and is under clinical trials in patients with idiopathic pulmonary fibrosis. We investigated the antifibrotic effect of pirfenidone, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782919d9483c3718a1bcefbdd3249020
https://pubmed.ncbi.nlm.nih.gov/18598692
https://pubmed.ncbi.nlm.nih.gov/18598692
Autor:
Kunio Hayashi, Masaru Kawakami, Tomoji Kawabata, Toshio Fujishita, Ryuichi Kiyama, Mariko Hara, Masafumi Fujimoto, Shigeyuki Nakajima
Publikováno v:
Chemicalpharmaceutical bulletin. 43(6)
A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-alpha]pyrimidine-3-carboxyli c acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an in vitro binding assay using COS cells transfected with a cDNA enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d585210667f980e807c46bf2d0cc60e4
https://pubmed.ncbi.nlm.nih.gov/7641315
https://pubmed.ncbi.nlm.nih.gov/7641315
Autor:
Shigeyuki Nakajima, Masaru Kawakami, Masafumi Fujimoto, Tomoji Kawabata, Toshio Fujishita, Koichi Ohtani, Mariko Hara, Ryuichi Kiyama, Koji Itazaki
Publikováno v:
European journal of pharmacology. 289(2)
Angiotensin AT1 receptor antagonists are divided into two types, surmountable, based on the way they inhibit angiotensin II-induced vasoconstriction. To elucidate what causes the difference, we studied how antagonists associate with and dissociate fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8d9020ec45366fbf9642d891cfa459
https://pubmed.ncbi.nlm.nih.gov/7621900
https://pubmed.ncbi.nlm.nih.gov/7621900
Autor:
Toshio Fujishita, Mariko Hara, Masahiro Fuji, Masuhisa Nakamura, Tomoji Kawabata, Masafumi Fujimoto, Ryuichi Kiyama
Publikováno v:
Chemicalpharmaceutical bulletin. 43(3)
Starting from recently reported nonpeptidic angiotensin II (AII) receptor antagonists, we have designed and prepared a new series of 6-arylimidazo[4,5-c]pyridine derivatives. Variation of phenyl groups at the 4-, 6- or 7-position of imidazo[4,5-c]pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207ac0a68020e2338024a720d04893d1
https://pubmed.ncbi.nlm.nih.gov/7774028
https://pubmed.ncbi.nlm.nih.gov/7774028
Autor:
Ikuko Takagawa, Fumiaki Marumo, Hikaru Koshida, Takashi Ida, Tomoji Kawabata, Limin Zhou, Yoshiyuki Matsuo, Masuhisa Nakamura
Publikováno v:
Pharmacology. 50(1)
To shed light on the role of thromboxane A2 (TXA2) in renal injury, we evaluated the effects of S-1452, a TXA2 receptor antagonist, on rats with streptozotocin (STZ)-induced diabetic nephropathy and murine lupus nephritis. In STZ diabetes rats (n = 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0011df68ecc5c333780fc1b92884b050
https://pubmed.ncbi.nlm.nih.gov/7899476
https://pubmed.ncbi.nlm.nih.gov/7899476
Autor:
Hiroo Imura, Yoshikazu Kambayashi, Kazuwa Nakao, Nobuo Yoshida, Ken Inouye, Tomoji Kawabata, Hiromi Kimura, Masuhisa Nakamura
Publikováno v:
Biochemical and biophysical research communications. 173(2)
We examined the diuretic-natriuretic activities of rat BNP and human BNP in anesthetized rats in vivo and their vasorelaxant activities for rat thoracic aorta and porcine coronary artery in vitro. Rat BNP was almost equipotent to rat ANP in diuresis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996f7f5038aee848ae90a9bc946f9d70
https://pubmed.ncbi.nlm.nih.gov/2260971
https://pubmed.ncbi.nlm.nih.gov/2260971