Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tomoichiro Miyoshi"'
Autor:
Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Proteomic analyses revealed that a group of interferon-stimulated genes suppresses LINE-1 retrotransposon activities, including HELZ2, which reduces LINE-1 RNA and the associated innate immune response levels.
Externí odkaz:
https://doaj.org/article/1eb5dddf7a114310a23918c5a3aac13f
Autor:
Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/e562859a83394e979617355667a0e650
Autor:
Hidenori Nakaoka, Masahiro Takikawa, Junko Kanoh, Sanki Tashiro, Tomoichiro Miyoshi, Io Yamamoto, Fuyuki Ishikawa
Publikováno v:
Nucleic Acids Research
Telomere binding protein Stn1 forms the CST (Cdc13/CTC1-STN1-TEN1) complex in budding yeast and mammals. Likewise, fission yeast Stn1 and Ten1 form a complex indispensable for telomere protection. We have previously reported that stn1-1, a high-tempe
Publikováno v:
Genesgenetic systems.
Genome sequencing revealed that nearly half of the human genome is comprised of transposable elements. Although most of these elements have been rendered inactive due to mutations, full-length intact long interspersed element-1 (LINE-1 or L1) copies
Publikováno v:
Genes & Genetic Systems; Jun2023, Vol. 98 Issue 3, p121-154, 34p
Some interferon stimulated genes (ISGs) encode proteins that inhibit LINE-1 (L1) retrotransposition. Here, we used immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd8a0194d264ecde99f43b6af5bad58
https://doi.org/10.1101/2022.03.26.485892
https://doi.org/10.1101/2022.03.26.485892
Publikováno v:
Mol Cell
Summary Long interspersed element-1 (LINE-1 or L1) retrotransposition poses a threat to genome integrity, and cells have evolved mechanisms to restrict retrotransposition. However, how cellular proteins facilitate L1 retrotransposition requires eluci
Autor:
Yutaka Suzuki, Takatomi Yamada, Charles S. Hoffman, Josephine Galipon, Tomoichiro Miyoshi, Naomichi Takemata, Kouji Hirota, Sumio Sugano, Kunihiro Ohta, Arisa Oda
Publikováno v:
Nucleic Acids Research
It has been postulated that a myriad of long noncoding RNAs (lncRNAs) contribute to gene regulation. In fission yeast, glucose starvation triggers lncRNA transcription across promoter regions of stress-responsive genes including fbp1 (fructose-1,6-bi
Publikováno v:
Bioarchitecture
Sexual reproduction involves diversification of genetic information in successive generations. Meiotic recombination, which substantially contributes to the increase in genetic diversity, is initiated by programmed DNA double-strand breaks (DSBs) cat
Autor:
Mitsuhiro Nakamura, Aurélien J. Doucet, Diane A. Flasch, Huira C. Kopera, John V. Moran, Tomoichiro Miyoshi
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933709
Long INterspersed Element-1 (LINE-1 or L1) retrotransposons encode two proteins (ORF1p and ORF2p) that are required for retrotransposition. The L1 element amplification protocol (LEAP) assays the ability of L1 ORF2p to reverse transcribe L1 RNA in vi