Výsledky vyhledávání - "Tomohisa Nagamatsu"

Akademický článek

Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

Autor: Doaa Samaha, Sawsan Mahmoud, Mosaad Sayed Mohamed, Rokaia S. Abdullah, Nageh A. Abou Taleb, Tomohisa Nagamatsu, Hamed I. Ali

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against

Externí odkaz: https://doaj.org/article/7e64012660c14ee68f7beb506c1e3ea9

Zobrazit plný text záznamu

Akademický článek

Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

Autor: Walaa A. Bedewy, Mosaad S. Mohamed, Ahmed M. Abdelhameed, Mohamed A. Elsawy, Mohammed Al-Muhur, Noriyuki Ashida, Ashraf N Abdalla, Tamer A. Elwaie, Tomohisa Nagamatsu, Hamed I. Ali

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line with IC50 of 0.5–190nM. Compounds 8c and 9g showed preferential activity against Hela cel

Externí odkaz: https://doaj.org/article/3ccb7b98f09f4334a648b495c54b1ef0

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN

Autor: Nanae Takahashi, Norio Akaike, Tomohisa Nagamatsu, Hiroyuki Uchino, Yoshihisa Kudo

Publikováno v: Journal of Pharmacological Sciences, Vol 151, Iss 2, Pp 93-109 (2023)

We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid. Since Alzheimer's type dementia develops slowly, we may be able to delay the onset and impr

Externí odkaz: https://doaj.org/article/4430eea1a40e48e4b054a405d131e58c

Zobrazit plný text záznamu

Akademický článek

Design, Synthesis, Antitumor Activity and Molecular Docking Study of Novel 5-Deazaalloxazine Analogs

Autor: Sawsan Mahmoud, Doaa Samaha, Mosaad S. Mohamed, Nageh A. Abou Taleb, Mohamed A. Elsawy, Tomohisa Nagamatsu, Hamed I. Ali

Publikováno v: Molecules, Vol 25, Iss 11, p 2518 (2020)

Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted alkylamino), 2-(heterocyclic substituted), 2-amino, 2,4-diox

Externí odkaz: https://doaj.org/article/18fc4024baa64d3293d2d71f5333959c

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Structural and functional analysis of phytotoxin toxoflavin-degrading enzyme.

Autor: Woo-Suk Jung, Jeehyun Lee, Myung-Il Kim, Jun Ma, Tomohisa Nagamatsu, Eunhye Goo, Hongsup Kim, Ingyu Hwang, Jaehong Han, Sangkee Rhee

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22443 (2011)

Pathogenic bacteria synthesize and secrete toxic low molecular weight compounds as virulence factors. These microbial toxins play essential roles in the pathogenicity of bacteria in various hosts, and are emerging as targets for antivirulence strateg

Externí odkaz: https://doaj.org/article/90d34b7232a2485f9d3b9cfac20df1f6

Zobrazit plný text záznamu

The protective effect of TND1128, with self-redox ability, on Ca2+ overloaded mouse brain slice and its comparison with β-NMN

Autor: Nanae Takahashi, Norio Akaike, Tomohisa Nagamatsu, Hiroyuki Uchino, Yoshihisa Kudo

Background and purpose: We have no definitive treatment for dementia characterized by prolonged neuronal death due to cerebrovascular degeneration or the enormous accumulation of foreign matters, such as β-amyloid. Since these diseases develop slowl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4ee2cc830f2532e49222ed33e90475
https://doi.org/10.22541/au.165285004.46260883/v1

Zobrazit plný text záznamu

The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology

Autor: Tomohisa Nagamatsu, Norio Akaike, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Kohei Oyabu, Katsunori Iwasaki

Publikováno v: Biochemical and biophysical research communications. 560

Adenosine triphosphate (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with brain diseases. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for energy pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a344351fb6209ca17a766f6014bf706a
https://pubmed.ncbi.nlm.nih.gov/33989906

Zobrazit plný text záznamu

Toxoflavin Produced by Burkholderia glumae Causing Rice Grain Rot Is Responsible for Inducing Bacterial Wilt in Many Field Crops

Autor: Yongsung Kang, Suhyun Kim, Tomohisa Nagamatsu, Yeonhwa Jeong, Ingyu Hwang, Jinwoo Kim

Publikováno v: Plant disease. 87(8)

Severe wilt symptoms similar to bacterial wilt caused by Ralstonia solanacearum were observed in tomato, hot pepper, eggplant, potato, perilla, sesame, and sunflower in 2000 and 2001 in Korea. From diseased crops at 65 different locations, we obtaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02559de5f3a8ac9060af50aa0d5de21b
https://pubmed.ncbi.nlm.nih.gov/30812790

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání