Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Tomohisa Kuzuyama"'
Autor:
Genki Hibi, Taro Shiraishi, Tatsuki Umemura, Kenji Nemoto, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Type II polyketide synthases (PKSs) normally synthesize polycyclic aromatic compounds in nature, and the potential to elaborate further diverse skeletons was recently revealed by the discovery of a polyene subgroup. Here, we show a type II P
Externí odkaz:
https://doaj.org/article/6be799ad3b484de7aee7bf12274d622b
Autor:
Sivamoke Dissook, Tomohisa Kuzuyama, Yuri Nishimoto, Shigeru Kitani, Sastia Putri, Eiichiro Fukusaki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous y
Externí odkaz:
https://doaj.org/article/fa24a3f4c39f48d4927044ce076bac47
Autor:
Masaya Kobayashi, Tomohisa Kuzuyama
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1147 (2020)
Structurally diverse carbazole alkaloids are valuable due to their pharmaceutical properties and have been isolated from nature. Experimental knowledge on carbazole biosynthesis is limited. The latest development of in silico analysis of the biosynth
Externí odkaz:
https://doaj.org/article/4281f6514fd64f859eb04acd6d67b89b
Autor:
Sumire Kurosawa, Fumihito Hasebe, Hironori Okamura, Ayako Yoshida, Kenichi Matsuda, Yusuke Sone, Takeo Tomita, Tetsuro Shinada, Hirosato Takikawa, Tomohisa Kuzuyama, Saori Kosono, Makoto Nishiyama
Publikováno v:
Journal of the American Chemical Society. 144:16164-16170
Natural products containing an aziridine ring, such as mitomycin C and azinomycin B, exhibit antitumor activities by alkylating DNA via their aziridine rings; however, the biosynthetic mechanisms underlying the formation of these rings have not yet b
Publikováno v:
Biochemistry.
Publikováno v:
Journal of the American Chemical Society. 144:5435-5440
Pyridoxal 5'-phosphate (PLP)-dependent enzymes are a group of versatile enzymes that catalyze various reactions, but only a small number of them react with O
Autor:
Yuxun Zhu, Taro Shiraishi, Jianwen Lin, Keito Inaba, Atsuro Ito, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Publikováno v:
Journal of the American Chemical Society. 144(37)
Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced by the soil-dwelling bacterium
Autor:
Tomohisa Kuzuyama, Yuri Nishimoto, Eiichiro Fukusaki, Sastia Prama Putri, Shigeru Kitani, Sivamoke Dissook
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarr
Autor:
Tetsuro Shinada, Makoto Nishiyama, Wei Li Thong, Tomohisa Kuzuyama, Satoshi Yuzawa, Jie Zhang
Publikováno v:
Journal of the American Chemical Society. 143:2962-2969
Natural products containing an o-dialkylbenzene moiety exhibit a wide variety of bioactivities, including antibacterial, antifungal, antitumor, and antiangiogenic activities. However, the biosynthetic scheme of the o-dialkylbenzene moiety remains unc
Autor:
Tomohisa Kuzuyama, Hikaru Suenaga, Junko Hashimoto, Takuya Hashimoto, Noritaka Kagaya, Takehiro Nishimura, Kazuo Shin-ya, Makoto Nishiyama
Publikováno v:
The Journal of Antibiotics. 74:354-358
Using genome mining approach, we identified a novel biosynthetic gene cluster containing trans-AT type PKS genes from Streptomyces versipellis 4083-SVS6. A bacterial artificial chromosome (BAC) clone, pKU503JL68_PN1_P10-C12, accommodating the entire