Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Tomohisa, Ishikawa"'
Autor:
Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, Miki Igarashi, Sumio Hayakawa, Kumiko Shoji, Yutaka Shoji, Tomohisa Ishikawa, Kenji Watanabe, Noriyuki Miyoshi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The increased incidence of obesity in the global population has increased the risk of several chronic inflammation-related diseases, including non-alcoholic steatohepatitis (NASH)-hepatocellular carcinoma (HCC). The progression from NASH to
Externí odkaz:
https://doaj.org/article/9d825bc443fe418db32f84592ce05524
Autor:
Megumi Kaji, Yukiko K. Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa
Publikováno v:
Frontiers in Nutrition, Vol 10 (2024)
IntroductionNobiletin is a polymethoxyflavonoid abundant in citrus peels and has been reported to have various bioactive effects. We have previously reported that nobiletin inhibits endoplasmic reticulum stress-induced apoptosis in the pancreatic β-
Externí odkaz:
https://doaj.org/article/cefd470eca1545a4bf29a0362286918a
Autor:
Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Shuken Boku, Kazunari Ishii, Manabu Ikeda, Minoru Takebayashi
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elu
Externí odkaz:
https://doaj.org/article/31a0da8ca37a4bc890cfa2f16102894e
Autor:
Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Shigeyuki Nakaji, Koichi Murashita, Songee Jung, Mina Misawa, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Moeko Noguchi-Shinohara, Junji Komatsu, Shutaro Shibata, Sohshi Yuki-Nozaki, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Yasuyo Fukada, Hisanori Kowa, Toshiya Nakano, Kenji Wada, Masafumi Kishi, Tomoki Ozaki, Ayumi Tachibana, Yuta Yoshino, Jun-ichi Iga Shu-ichi Ueno, Tomohisa Ishikawa, Seiji Yuki, Asuka Koyama, Naoto Kajitani, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Kazuhiro Uchida, Midori Esaki, Benjamin Thyreau, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Izen Ri, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo, Yutaka Kiyohara
Publikováno v:
Kidney Medicine, Vol 5, Iss 3, Pp 100593- (2023)
Rationale & Objective: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few
Externí odkaz:
https://doaj.org/article/f949a496ee634343aad2d9f87a576ac3
Autor:
Hiroyuki Sasaki, Tadashi Jono, Ryuji Fukuhara, Kazuki Honda, Tomohisa Ishikawa, Shuken Boku, Minoru Takebayashi
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background The age of attention-deficit/hyperactivity disorder onset is usually during the first 12 years of life; however, there have been recent reports of late-onset attention-deficit/hyperactivity disorder. These reports have been limite
Externí odkaz:
https://doaj.org/article/bce05f90e2474c9fae543415dff18e10
Autor:
Kazuhiro Yoshiura, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Yusuke Miyagawa, Yosuke Hidaka, Mamoru Hashimoto, Manabu Ikeda, Minoru Takebayashi, Megumi Shimodozono
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia than those with MCI or PF alone, but there are few know
Externí odkaz:
https://doaj.org/article/5e4be33a4d134b8aaca239791a7606bb
Autor:
Yukiko K. Kaneko, Yuki Tara, Stella Amarachi Ihim, Moe Yamamoto, Megumi Kaji, Tomohisa Ishikawa
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 4, Pp 100367- (2022)
Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic an
Externí odkaz:
https://doaj.org/article/1f45d57433f343509be7c2f6f45b2511
Autor:
Tempei Ikegame, Yosuke Hidaka, Yutaka Nakachi, Yui Murata, Risa Watanabe, Hiroko Sugawara, Tatsuro Asai, Emi Kiyota, Takeo Saito, Masashi Ikeda, Tsukasa Sasaki, Mamoru Hashimoto, Tomohisa Ishikawa, Minoru Takebayashi, Nakao Iwata, Chihiro Kakiuchi, Tadafumi Kato, Kiyoto Kasai, Miki Bundo, Kazuya Iwamoto
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract SLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each of which has 14 or 16 tandem
Externí odkaz:
https://doaj.org/article/17b9c7fc185445e79c6e9a586755ede8
Autor:
Takayuki Tabira, Maki Hotta, Miki Murata, Kazuhiro Yoshiura, Gwanghee Han, Tomohisa Ishikawa, Asuka Koyama, Noriyuki Ogawa, Michio Maruta, Yuriko Ikeda, Takaaki Mori, Taku Yoshida, Mamoru Hashimoto, Manabu Ikeda
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 10, Iss 1, Pp 27-37 (2020)
Background/Aims: Age-related changes in impairments in activities of daily living (ADL) in older adults with very mild Alzheimer’s disease (vmAD) have been scarcely explored. We clarified the characteristics of ADL impairment and examined how ADL i
Externí odkaz:
https://doaj.org/article/70c02689672c461d9b9b5306343c3cc9
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111989- (2021)
Background and aims: Liver inflammation leads to the activation of hepatic stellate cells (HSCs), resulting in the development of liver fibrosis. The present study aimed to investigate the effects of prostaglandin E2 (PGE2), which is biosynthesized b
Externí odkaz:
https://doaj.org/article/d1899e2163294fd88a551f29cddccf74