Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tomohiro Yoshinari"'
Autor:
Takeyuki Nagashima, Tomohiro Yoshinari, Yoshihiro Nishizono, Mamoru Tasaki, Kohei Inamura, Hiroki Ishioka, Atsushi Suzuki, Fumio Osaki, Yosuke Yamanaka, Masahiko Hayakawa
Publikováno v:
Cancer Research. 83:5735-5735
KRAS is one of the most frequently mutated oncogenes in various cancers. Among KRAS mutations, KRAS G12D is the most frequent driver mutation and is found in approximately 34% of patients with pancreatic ductal adenocarcinoma (PDAC), 12% of patients
Autor:
Seebach, Dieter1, Tomohiro Yoshinari1, Beck, Albert K.1, Ebert, Marc-Olivier1, Castro-Alvarez, Alejandro2, Vilarrasa, Jaume2, Reiher, Markus3
Publikováno v:
Helvetica Chimica Acta. Sep2014, Vol. 97 Issue 9, p1177-1203. 27p.
Autor:
Dieter Seebach, Jaume Vilarrasa, Tomohiro Yoshinari, Alejandro Castro-Alvarez, Marc-Olivier Ebert, Markus Reiher, Albert K. Beck
Publikováno v:
Helvetica Chimica Acta. 97:1177-1203
Under the 'best anhydrous' conditions, we were able to achieve, the bicyclic oxazolidinones derived from proline and pivalaldehyde (or cyclohexanone) equilibrate with added carbonyl compounds in (D-6)DMSO and in (D-6)benzene. With (O-18)cyclohexanone
Autor:
Renzo Cescato, Christof Sparr, Harald Hübner, Beata Kolesinska, Beatrice Waser, Simone Maschauer, Dieter Seebach, Peter Gmeiner, Nirupam Purkayastha, Tomohiro Yoshinari, Jean Claude Reubi, Olaf Prante
Publikováno v:
Chemistry & Biodiversity. 10:2101-2121
Neurotensin(8-13) (NTS(8-13)) analogs with C- and/or N-terminal β-amino acid residues and three DOTA derivatives thereof have been synthesized (i.e., 1-6). A virtual docking experiment showed almost perfect fit of one of the 1,4,7,10-tetraazacyclodo
Autor:
Tomohiro Yoshinari, Dieter Seebach, Lynne B. McCusker, Dubravka Sisak Jung, Christian Baerlocher
Publikováno v:
Journal of Applied Crystallography
While the powder charge flipping (pCF) algorithm has been applied successfully to a variety of inorganic compounds, reports on its application to organic structures, in particular those consisting of light atoms only, are rare. To investigate the rea
Publikováno v:
Helvetica Chimica Acta. 94:1908-1942
The preparation of (2S,3S)- and (2R,3S)-2-fluoro and of (3S)-2,2-difluoro-3-amino carboxylic acid derivatives, 1–3, from alanine, valine, leucine, threonine, and β3h-alanine (Schemes 1 and 2, Table) is described. The stereochemical course of (diet
Publikováno v:
Applied Catalysis B: Environmental. 44:67-78
The addition of small amounts of rhodium enhanced the activity of Ag/Al 2 O 3 catalyst for the selective reduction of NO with decane at low temperatures. The Rh-promoted Ag/Al 2 O 3 showed its high performance even in the presence of low concentratio
Publikováno v:
International Journal of Pharmaceutics. 258:121-131
We have previously shown that by exposing one form of mannitol to high relative humidity, a moisture-induced polymorphic transition of mannitol with a concurrent change in particle morphology occurs [Int. J. Pharm. 247 (2002) 69]. In this paper, we p
Publikováno v:
Applied Catalysis B: Environmental. 41:157-169
Silica-supported iridium catalyst showed excellent activity for NO reduction with H2 in the presence of O2 and SO2. This reaction took place only on Ir and Rh/SiO2, whereas on Pt, Pd and Ru/SiO2 SO2 showed inhibiting effect on NO reduction. SiO2 was
Publikováno v:
International Journal of Pharmaceutics. 247:69-77
The effects of moisture on the polymorphic transition of crystalline mannitol were investigated. Mannitol has three polymorphic forms, and was classified as alpha, beta, and delta form, respectively, by Walter-Lévy (C.R. Acad. Sc. Paris Ser. C (1968