Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Tomohiro Yoshimoto"'
Autor:
Ayumi Fukuoka, Tomohiro Yoshimoto
Publikováno v:
Allergology International, Vol 67, Iss 1, Pp 18-23 (2018)
Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell–cell junctional complex located on the apical side of epithelial cells, have a critical role in the
Externí odkaz:
https://doaj.org/article/b64a871e9f724e1b85f33aa4fcfba754
Autor:
Toru Kato, Koubun Yasuda, Kazufumi Matsushita, Ken J. Ishii, Seiichi Hirota, Tomohiro Yoshimoto, Hiroaki Shibahara
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6–10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cyst
Externí odkaz:
https://doaj.org/article/aef1428eac86400eb3ebe701a3f4e689
Autor:
Tomohiro Yoshimoto
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4+ T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to
Externí odkaz:
https://doaj.org/article/5eafccb693934acfa7b393baf1a396e2
Publikováno v:
Allergology International, Vol 64, Iss 3, Pp 235-240 (2015)
Recent advances in our understanding of proallergic cytokines and group 2 innate lymphoid cells (ILC2s) indicate their critical roles in type 2 immunity-mediated disorders. Proallergic cytokines, interleukin (IL)-25, IL-33, and thymic stromal lymphop
Externí odkaz:
https://doaj.org/article/607a041c2929471e86ddad8fc4ad81cb
Publikováno v:
Allergology International, Vol 63, Iss S1, Pp 3-11 (2014)
We propose two types of allergic response: IgE-dependent and IgE-independent, and designate these as 'acquired-type allergy' and 'innate-type allergy', respectively. IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cell
Externí odkaz:
https://doaj.org/article/10cd6913f35c4299a418e2a07a703a30
Autor:
Hiroshi Shiraishi, Miho Masuoka, Shoichiro Ohta, Shoichi Suzuki, Kazuhiko Arima, Kazuto Taniguchi, Shigehisa Aoki, Shuji Toda, Tomohiro Yoshimoto, Naoki Inagaki, Simon J Conway, Yutaka Narisawa, Kenji Izuhara
Publikováno v:
Allergology International, Vol 61, Iss 4, Pp 563-572 (2012)
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. Keratinocytes persistently secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We have recently
Externí odkaz:
https://doaj.org/article/54a307a5f6954527a6ce92516717a7ba
Autor:
Yukinori Kato, Shoko Akasaki, Yoko Muto-Haenuki, Shigeharu Fujieda, Kazufumi Matsushita, Tomohiro Yoshimoto
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103540 (2014)
Recently, the concept of local allergic rhinitis (LAR) was established, namely rhinitis symptoms with local IgE production and negative serum antigen-specific IgE. However, the natural course of LAR development and the disease pathogenesis is poorly
Externí odkaz:
https://doaj.org/article/eefd015a07764c53aa3318b09a34b6ac
Autor:
Shizuo Akira, Hiroki Tanaka, Tomohiro Yoshimoto, Koubun Yasuda, Ayumi Fukuoka, Kazufumi Matsushita, Takumi Adachi, Shoko Akasaki, Atsuhide Koida, Etsushi Kuroda
Publikováno v:
JCI Insight. 5
Group 2 innate lymphoid cells (ILC2s) are a critical innate source of type 2 cytokines in allergic inflammation. Although ILC2s are recognized as a critical cell population in the allergic inflammation, the regulatory mechanism(s) of ILC2s are less w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb7785b8eb572f1f241739ca114fb68
https://doi.org/10.1172/jci.insight.131480
https://doi.org/10.1172/jci.insight.131480
Autor:
Hiroshi Arima, Kiyotaka Izumi, Akifumi Takaori-Kondo, Tomohiro Yoshimoto, Koubun Yasuda, Momoko Nishikori, Wataru Kishimoto, Yasuyuki Otsuka
Publikováno v:
Blood Advances. 2:2282-2295
The Notch-signaling pathway in a variety of mature B-cell neoplasms is often activated by gene alterations, but its role remains unclear. Here, we show that B cells harboring dysregulated activation of Notch1 signaling have an immunomodulatory effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42676345d937cfb69682325d9e27d6e9
https://doi.org/10.1182/bloodadvances.2018019919
https://doi.org/10.1182/bloodadvances.2018019919
Autor:
Koubun Yasuda, Naruhito Iwasaki, Shigeharu Fujieda, Taiyo Morikawa, Kazufumi Matsushita, Ayumi Fukuoka, Shoko Akasaki, Tomohiro Yoshimoto
Publikováno v:
International Immunology. 29:221-233
Both Th2 cells and group 2 innate lymphoid cells (ILC2s) contribute to allergic diseases. However, their exact role and relationship in nasal allergic disorders are unclear. In this study, we investigated the cooperation of Th2 cells and ILC2s in a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dbf6928d1e1c75c8aa1ee19c9c7277
https://doi.org/10.1093/intimm/dxx030
https://doi.org/10.1093/intimm/dxx030