Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Tomohiro Yonezawa"'
Publikováno v:
Open Veterinary Journal, Vol 14, Iss 5, Pp 1259-1268 (2024)
Background: Canine prostatic carcinoma (cPC) is a urogenital tumor with poor prognosis, for which no effective treatment has been established. Recently, it has been shown that human epidermal growth factor receptor type 2 (HER2) is overexpressed in c
Externí odkaz:
https://doaj.org/article/f76c0816048d436b94cbe54d77067744
Autor:
Tomohiro Yonezawa, Shinya Takenouchi, Tomoki Motegi, Michiyo Miyazaki, Nanae Nagata, Koji Kobayashi, Masaki Yamada, Takahisa Murata
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionIdiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs. In this study, the concentrations of 196 lipid metabolites and nitrogen oxide (NO) production i
Externí odkaz:
https://doaj.org/article/86c81e62638e43e0a764785670d12ea7
Publikováno v:
Open Veterinary Journal, Vol 13, Iss 7, Pp 846-853 (2023)
Background: Idiopathic epilepsy in cats is a more common disease than previously thought, but little information is available about the medical treatment of feline idiopathic epilepsy. Aim: To assess the therapeutic efficacy and safety of antiseizure
Externí odkaz:
https://doaj.org/article/60f422c8dd1e420e99010353b372b33f
Autor:
Tomohiro Yonezawa, Cris Niño Bon B. Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, Yasuyuki Momoi
Publikováno v:
Open Veterinary Journal, Vol 13, Iss 7, Pp 942-947 (2023)
Background: The anti-epileptic effects of docosahexaenoic acid (DHA) in dogs and humans remain controversial. The dosage and efficacy of DHA were various in the previous reports. Aim: The effects of high-dose DHA supplementation as add-on therapy for
Externí odkaz:
https://doaj.org/article/c70801848471470a8feaf31abe8908a6
Autor:
Maho Nakazawa, Ryota Tochinai, Wataru Fujii, Mao Komori, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0283915 (2024)
Anaphylaxis is a severe life-threatening hypersensitivity reaction induced by mast cell degranulation. Among the various mediators of mast cells, little is known about the role of tryptase. Therefore, we aimed to elucidate the role of protease-activa
Externí odkaz:
https://doaj.org/article/904d832265e349ca868f3539a3eeaa7c
Publikováno v:
Journal of Feline Medicine and Surgery Open Reports, Vol 10 (2024)
Case summary The patient was a castrated male American Shorthair cat, approximately 14 years old, weighing 3.4 kg. The patient had chronic kidney disease (CKD) (International Renal Interest Society stages 3–4) as an underlying disease. The cat was
Externí odkaz:
https://doaj.org/article/3cfe80f6f32c4b07b3d101cd4dded7b9
Autor:
Shingo Maeda, Kosei Sakai, Kenjiro Kaji, Aki Iio, Maho Nakazawa, Tomoki Motegi, Tomohiro Yonezawa, Yasuyuki Momoi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Epidermal growth factor receptors 1 and 2 (EGFR and HER2) are frequently overexpressed in various malignancies. Lapatinib is a dual tyrosine kinase inhibitor that inhibits both EGFR and HER2. Although a phase III trial failed to show the sur
Externí odkaz:
https://doaj.org/article/a019967eeffe4429810c53290abf9c23
Autor:
Tomoki Motegi, Takayuki Nakagawa, Shingo Maeda, Aki Iio, Kenjiro Kaji, Yuko Goto-Koshino, Shotaro Eto, Namiko Ikeda, Ryohei Nishimura, Tomohiro Yonezawa, Yasuyuki Momoi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background Targeting regulatory T cell (Treg) infiltration is an emerging strategy for cancer immunotherapy. However, its efficacy in advanced prostate cancer remains unclear. Here, we showed the therapeutic efficacy of anti-Treg treatment in a canin
Externí odkaz:
https://doaj.org/article/a31d4e8d108b4347a9e966ac1b63ac80
Autor:
Mrinal K. Ghosh, Kuan-hui E. Chen, Riva Dill-Garlow, Lisa J. Ma, Tomohiro Yonezawa, Yuichiro Itoh, Lorena Rivera, Kelly C. Radecki, Quiming P. Wu, Arthur P. Arnold, H. Konrad Muller, Ameae M. Walker
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
We have used the four core genotypes (FCG) mouse model, which allows a distinction between effects of gonadal secretions and chromosomal complement, to determine when sex differences in the immune system first appear and what influences their develop
Externí odkaz:
https://doaj.org/article/a960ef55627945e48c9d1124f4429cf7
Publikováno v:
Animals, Vol 12, Iss 4, p 485 (2022)
This study aimed to establish a method to detect canine urothelial carcinoma cells in urine using 5-aminolevulinic acid (5-ALA) and to evaluate its diagnostic accuracy. Urine samples were collected from 21 dogs diagnosed with urothelial carcinoma and
Externí odkaz:
https://doaj.org/article/67c007805c8c4d629e49889579d4d1a1