Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tomohiro Tsujita"'
Autor:
Hideki Uryu, Takashi Nakamura, Daisuke Nakashima, Kazuyoshi Yamamoto, Yu Honda, Masahiro Ishikawa, Tomohiro Tsujita, Norihiko Hata, Toshinori Oinuma, Hiroyuki Yamazaki, Yuichi Yahagi
Publikováno v:
Journal of Infection and Chemotherapy. 29:361-366
Autor:
Tomohiro, Tsujita, Norihiko, Hata
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 46(4)
The patient was a 68-year-old woman. She was diagnosed with invasive thymoma 12years prior and underwent chemoradiotherapy( adriamycin, cisplatin, vincristine, and cyclophosphamide: ADOC)plus radiation exposure(62G y). After 11 years, the disease rel
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 45(11)
The patient was a 66-year-old male. Following surgery for pulmonary adenocarcinoma in the upper right lobe and adjuvant chemotherapy, the patient relapsed. We carried out treatment using the immune checkpoint inhibitor pembrolizumab (KEYTRUDA®)for h
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 45(8)
The subject was a 63-year-old man. The patient was transported by ambulance to the hospital because of dyspnea caused by carcinomatous pleurisy and carcinomatous pericarditis, after which pericardial drainage was performed; however, Staphylococcus au
Autor:
Takashi Yoshizumi, Hisashi Ohta, Hiroshi Miyazoe, Kensuke Kobayashi, Masanori Asai, Satoshi Ozaki, Yasuyuki Ishii, Osamu Okamoto, Hiroki Sakoh, Takeshi Tani, Mioko Hirayama, Tomohiro Tsujita, Minaho Uchiyama, Hirokatsu Ito, Hirobumi Takahashi, Yasushi Nagatomi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3627-3631
The synthesis and biological evaluation of new potent opioid receptor-like 1 antagonists are presented. A structure-activity relationship (SAR) study of arylpyrazole lead compound 1 obtained from library screening identified compound 31, (1S,3R)-N-{[
Autor:
Hideo Kigoshi, Tomohiro Tsujita, Akio Ohno, Hirobumi Takahashi, Ichiro Hayakawa, Osamu Okamoto, Takashi Yoshizumi
Publikováno v:
Synthesis. 2009:1153-1162
Practical syntheses of enantiomerically pure key intermediates of opioid receptor-like 1 (ORL1) antagonists are described. Our synthetic methodology features the preparation of multigram quantities of seven-membered key intermediate (-)-3 and six-mem
Autor:
Satoshi Ozaki, Hiroshi Miyazoe, Hisashi Ohta, Masanori Asai, Hirobumi Takahashi, Osamu Okamoto, Hirokatsu Ito, Takashi Yoshizumi, Tomohiro Tsujita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3778-3782
Based on reported structures, a focused library of biarylmethyl bound to the nitrogen atom of spiropiperidine was designed. Systematic modifications allowed the discovery of a synthetically feasible and highly potent ORL1 antagonist 37, 1'-{[1-(3-chl
Autor:
Takeshi Tani, Hisashi Ohta, Tetsuya Kato, Tomohiro Tsujita, Hirobumi Takahashi, Hirokatsu Ito, Mioko Hirayama, Kiyoshi Tadano, Tomoko Azuma-Kanoh, Hiroshi Kawamoto, Masato Chiba, Daisuke Ichikawa, Osamu Okamoto, Yuichi Sugimoto, Takahiro Fukuroda, Yoshihiro Shibata, Satoshi Ozaki, Takashi Yoshizumi, Shoki Okuda, Hiroshi Miyazoe, Yasuyuki Ishii
Publikováno v:
Journal of Medicinal Chemistry. 51:4021-4029
A series of compounds based on 7-{[4-(2-methylphenyl)piperidin-1-yl]methyl}-6,7,8,9-tetrahydro-5 H-cyclohepta[ b]pyridine-9-ol ( (-)-8b), a potent and selective opioid receptor-like 1 (ORL1) antagonist, was prepared and evaluated using structure-acti
Publikováno v:
Tetrahedron Letters. 42:4665-4668
Total synthesis of (±)-cheimonophyllon E was accomplished starting from 3-methyl-2-cyclohexen-1-one. Also, synthesis of (+)-cheimonophyllon E, the natural enantiomer, was achieved through optical resolution of a key intermediate in the racemic synth
Publikováno v:
ChemInform. 32
Total synthesis of (±)-cheimonophyllon E was accomplished starting from 3-methyl-2-cyclohexen-1-one. Also, synthesis of (+)-cheimonophyllon E, the natural enantiomer, was achieved through optical resolution of a key intermediate in the racemic synth