Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tomohiro Shigemori"'
Publikováno v:
Journal of Biotechnology. 209:96-101
Glucagon-like peptide-1 (GLP1) is a 30-amino acid peptide hormone activating the GLP1 receptor (GLP1R), a class B G-protein coupled receptor (GPCR), and is considered to be effective for treating diabetes and other metabolic diseases. Phage display i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5c1d2cbba4a0c265b135bd23c50350
https://doi.org/10.1016/j.jbiotec.2015.06.392
https://doi.org/10.1016/j.jbiotec.2015.06.392
Autor:
Keisuke Hara, Tomohiro Shigemori, Kouichi Kuroda, Sanae Morioka, Hironobu Morisaka, Mitsuyoshi Ueda
Publikováno v:
Applied Microbiology and Biotechnology. 97:4013-4020
The main sterol of the human cell membrane is cholesterol, whereas in yeast it is ergosterol. In this study, we constructed a cholesterol-producing yeast strain by disrupting the genes related to ergosterol synthesis and inserting the genes related t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb6f24d4a25c62744e24737c7f72d36
https://doi.org/10.1007/s00253-012-4470-9
https://doi.org/10.1007/s00253-012-4470-9
Autor:
Tomohiro Shigemori, Mio Iwasaki, Keitaro Ito, Sou Nakamura, Masato Nakagawa, Kosuke Fujio, Akira Sawaguchi, Masayuki Nogawa, Ito Yukitaka, Koji Eto, Ken ichi Harimoto, Kato Yoshikazu, Kazuya Hashimoto, Makoto Handa, Takuya Matsumoto, Fumihito Arai, Mikiko Ohno, Natsumi Higashi, Naoshi Sugimoto, Takuya Yamamoto, Okamoto Haruki, Shunsuke Kihara, Hiroki Kumon, Hidenori Hirose, Shinya Sakuma, Naohide Watanabe, Satoshi Nishimura, Eiichiro Nishi
Publikováno v:
Cell. 174:636-648.e18
The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is expected to compensate donor-dependent transfusion systems. However, manufacturing the clinically required number of platelets remains unachieved due to the low plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd5a33c01db728d0fa3ee6343bc3e45
https://doi.org/10.1016/j.cell.2018.06.011
https://doi.org/10.1016/j.cell.2018.06.011
Publikováno v:
The Journal of Nutrition. 135:2987S-2992S
In the present study, we explored the suppressive activities of 1'-acetoxychavicol acetate (ACA), auraptene, nobiletin, and zerumbone toward LPS-induced cyclooxygenase (COX)-2 mRNA expression in mouse macrophages and the underlying molecular mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d863fd6f7786296cfc7d4085177da
https://doi.org/10.1093/jn/135.12.2987s
https://doi.org/10.1093/jn/135.12.2987s
Publikováno v:
The FASEB Journal. 28
G-protein coupled receptors (GPCRs) which feature a seven-transmembrane structure are involved in various diseases as well as in regulating physiological functions. Phage display has been used for ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70566b67e4cb4292fd7c5903f50bc77b
https://doi.org/10.1096/fasebj.28.1_supplement.654.5
https://doi.org/10.1096/fasebj.28.1_supplement.654.5
Autor:
Tohoru Katsuragi, Natsuko Miura, Tomohiro Shigemori, Mitsuyoshi Ueda, Kouichi Kuroda, Junki Yamada, Mitsuru Nagayama, Suganya Yongkiettakul
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4406ca55139c52000e5f51c44fe1a0e6
https://doi.org/10.1096/fasebj.27.1_supplement.894.4
https://doi.org/10.1096/fasebj.27.1_supplement.894.4
Autor:
Keisuke Hara, Tomohiro Shigemori, Sanae Morioka, Hironobu Morisaska, Mitsuyoshi Ueda, Kouichi Kuroda
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23e983b8c76750755d2668c5e5f42b2
https://doi.org/10.1096/fasebj.27.1_supplement.1096.8
https://doi.org/10.1096/fasebj.27.1_supplement.1096.8
Autor:
Masayuki Nogawa, Naoshi Sugimoto, Naohide Watanabe, Tomohiro Shigemori, Makoto Handa, Satoshi Nishimura, Kazuya Hashimoto, Kato Yoshikazu, Ito Yukitaka, Koji Eto, Sou Nakamura
Publikováno v:
Blood. 128:2181-2181
Each transfusion requires 200-300 billion platelets in patients with thrombocytopenia. To continuously supply such a huge number of platelets by ex vivo generation, two distinct steps, megakaryopoiesis and platelet shedding, must be both considered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4eac1f90af1818e4cd070f37bffbcb9
https://doi.org/10.1182/blood.v128.22.2181.2181
https://doi.org/10.1182/blood.v128.22.2181.2181
Publikováno v:
AMB Express
The G-protein-coupled receptor (GPCR) superfamily, which includes somatostatin receptors (SSTRs), is one of the most important drug targets in the pharmaceutical industry. The yeast Saccharomyces cerevisiae is an attractive host for the ligand screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b4e9e0293e95132bf583289a7a78f2
http://europepmc.org/articles/PMC3558460
http://europepmc.org/articles/PMC3558460
Autor:
Mitsuru Nagayama, Tohoru Katsuragi, Tomohiro Shigemori, Junki Yamada, Mitsuyoshi Ueda, Kouichi Kuroda, Suganya Yongkiettrakul, Natsuko Miura
Publikováno v:
FEBS Open Bio
Neuraminidase (NA) is a surface glycoprotein produced by the influenza virus. Specific NA mutations that confer resistance to anti-viral drugs have been reported. The aim of this study was to demonstrate quick preparation of the mutated NAs using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90444309e38603a8a9a9b4855a35fd3e