Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Tomohiro Onodera"'
Autor:
Tomohiro Onodera, Koji Iwasaki, Masatake Matsuoka, Yasuhide Morioka, Shinji Matsubara, Eiji Kondo, Norimasa Iwasaki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Total knee arthroplasty (TKA) is an effective procedure for pain relief; however, the emergence of postsurgical pain remains a concern. In this study, we investigated the production of nerve growth factor (NGF) and mediators that affect NGF
Externí odkaz:
https://doaj.org/article/59ea44335b4f4228b2bd2e24c2ef7976
Autor:
Yuki Suzuki, Yasumitsu Ohkoshi, Kensaku Kawakami, Kenta Shimizu, Shuya Chida, Kengo Ukishiro, Tomohiro Onodera, Koji Iwasaki, Tatsunori Maeda, Sho’ji Suzuki, Eiji Kondo, Norimasa Iwasaki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract During progression of knee osteoarthritis (OA), gait biomechanics changes three-dimensionally; however, its characteristics and trunk posture according to OA severity remain unknown. The present study investigated three-dimensional knee join
Externí odkaz:
https://doaj.org/article/e8edc2d335374b95bceb6f930fc498c4
Autor:
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki
Publikováno v:
eLife, Vol 12 (2024)
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model wa
Externí odkaz:
https://doaj.org/article/ad0a205eda70458e8bba0b5b1842d893
Autor:
Yuki Sasaki, Kosuke Ishikawa, Kanako C. Hatanaka, Yumiko Oyamada, Yusuke Sakuhara, Tadashi Shimizu, Tatsuro Saito, Naoki Murao, Tomohiro Onodera, Takahiro Miura, Taku Maeda, Emi Funayama, Yutaka Hatanaka, Yuhei Yamamoto, Satoru Sasaki
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Background Klippel–Trenaunay syndrome (KTS) is a rare slow-flow combined vascular malformation with limb hypertrophy. KTS is thought to lie on the PIK3CA-related overgrowth spectrum, but reports are limited. PIK3CA encodes p110α, a cataly
Externí odkaz:
https://doaj.org/article/b88c018bb5c14062bd0c85b60103e7c1
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4890 (2024)
Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical components of vertebrate plasma membranes, playing a pivotal role in cellular signaling and interactions. In human articular cartilage in osteoarthritis (OA), GS
Externí odkaz:
https://doaj.org/article/2fb25844ea67400a939420713cc2cd25
Autor:
Ryosuke Hishimura, Tomohiro Onodera, Yasumitsu Ohkoshi, Kazufumi Okada, Masatake Matsuoka, Shinji Matsubara, Koji Iwasaki, Eiji Kondo, Norimasa Iwasaki
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-7 (2022)
Abstract Background Tranexamic acid (TXA) is used as a synthetic anti-fibrinolytic agent for total knee arthroplasty (TKA) to reduce postoperative bleeding. Though the effects on bleeding reduction of several methods of administering TXA have been de
Externí odkaz:
https://doaj.org/article/580391c2e9fc4877a08cbaea640d26f5
Autor:
Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Naoki Seito, Susumu Mikami, Norimasa Iwasaki
Publikováno v:
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Articular surface damage commonly associated with rupture of the anterior cruciate ligament (ACL). Large osteochondral defect, which consists of a severe depression fracture and a large cartilage defect, need to be treated due to
Externí odkaz:
https://doaj.org/article/4bd43457b5db4ea688a6eed44246931e
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 154-159 (2020)
Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 a
Externí odkaz:
https://doaj.org/article/f2cf6c3f296942d5867aa1f8efd7c72d
Autor:
Dai Sato, Eiji Kondo, Koji Yabuuchi, Jun Onodera, Tomohiro Onodera, Tomonori Yagi, Keita Sakamoto, Akira Takasawa, Norimasa Iwasaki, Kazunori Yasuda
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background To perform medial open-wedge high tibial osteotomy (OWHTO), surgeons expose the medial-proximal tibia by releasing or cutting the superficial layer of the medial collateral ligament (sMCL). Biomechanically, the sMCL provides prima
Externí odkaz:
https://doaj.org/article/08e05da4c5ea4519869a316f44aa48ff
Autor:
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102643- (2021)
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA. In this study, we analyzed the molecular response of c
Externí odkaz:
https://doaj.org/article/e74a4b47c9f4466e90de54e64bac8b2f