Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Tomohiro KONO"'
Autor:
Takafumi Utsunomiya, Tatsuma Yao, Hiroko Itoh, Yufuko Kai, Yoko Kumasako, Miwa Setoguchi, Naomi Nakagata, Osamu Tsutsumi, Kaoru Yanagida, Yoshinori Fukuda, Tomohiro Kono
Publikováno v:
Fertility & Reproduction, Vol 05, Iss 04, Pp 318-318 (2023)
Background and Aims: Although culture conditions were recognized as key points, an optimal culture medium formulation, which closely resembles natural human oviduct fluid (HOF), has not been obtained yet. Our aim is to make an ideal embryo culture me
Externí odkaz:
https://doaj.org/article/89e8c7ec69df4d7aaeca1f5a71474082
Autor:
Shinya IKEDA, Koki TANAKA, Reiko OHTANI, Akifumi KANDA, Yusuke SOTOMARU, Tomohiro KONO, Yayoi OBATA
Publikováno v:
The Journal of Reproduction and Development, Vol 68, Iss 2, Pp 125-136 (2022)
In the male germline, the machinery to repress retrotransposons that threaten genomic integrity via the piRNA pathway is established in gonocytes. It has been reported that disruption of the piRNA pathway leads to activation of retrotransposons and a
Externí odkaz:
https://doaj.org/article/5d74fd8e88ef4cfa8f8cee2f05a201b6
Autor:
Takafumi Utsunomiya, Tatsuma Yao, Hiroko Itoh, Yufuko Kai, Yoko Kumasako, Miwa Setoguchi, Naomi Nakagata, Hiroyuki Abe, Motoharu Ishikawa, Koichi Kyono, Hiroaki Shibahara, Osamu Tsutsumi, Yukihiro Terada, Shunsaku Fujii, Kaoru Yanagida, Minesuke Yokoyama, Sueo Niimura, Tsuyoshi Endo, Yoshinori Fukuda, Masato Inoue, Tomohiro Kono, Naoaki Kuji, Fumiko Tawara, Hiroaki Yoshida, Yoshimasa Yokota, Yoshihiro Tada
Publikováno v:
Reproductive Medicine and Biology, Vol 21, Iss 1, Pp n/a-n/a (2022)
Abstract Purpose Our aim is to make an ideal embryo culture medium close to human oviduct fluid (HOF) components, and to evaluate the quality of this medium with embryo quality and clinical outcomes in assisted reproductive technology (ART) by a pros
Externí odkaz:
https://doaj.org/article/eb2a1c2dd1054f7aa46f42552fd480e5
Publikováno v:
Poultry Science, Vol 100, Iss 5, Pp 101046- (2021)
Japanese quail is a low-fat, meat-bird species exhibiting high disease resistance. Cathelicidins (CATHs) are host defense peptides conserved across numerous vertebrate species that play an important role in innate immunity. The activity of host defen
Externí odkaz:
https://doaj.org/article/0acc3024c06e480298575c2ed6e0e499
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254674 (2021)
Trophoblast giant cells (TGCs), a mouse trophoblast subtype, have large amounts of cytoplasm and high ploidy levels via endocycles. The diverse functions and gene expression profiles of TGCs have been studied well, but their nuclear structures remain
Externí odkaz:
https://doaj.org/article/6e079b277a444030bd2c7a0fe7a9cd33
Autor:
Ippei Nagamori, Hisato Kobayashi, Toru Nishimura, Reina Yamagishi, Jun Katahira, Satomi Kuramochi-Miyagawa, Tomohiro Kono, Toru Nakano
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 350-356 (2018)
Summary: Retrotransposon genes are silenced by DNA methylation because of potential harm due to insertional mutagenesis. DNA methylation of retrotransposon genes is erased and re-established during male germ cell development. Both piRNA-dependent and
Externí odkaz:
https://doaj.org/article/b818a30ab362422b891255662b8da9e1
Autor:
Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono, Matthew C. Lorincz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syn
Externí odkaz:
https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09
Autor:
Keiichiro Joh, Fumikazu Matsuhisa, Shuji Kitajima, Kenichi Nishioka, Ken Higashimoto, Hitomi Yatsuki, Tomohiro Kono, Haruhiko Koseki, Hidenobu Soejima
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-11 (2018)
Abstract Background Zrsr1 is a paternally expressed imprinted gene located in the first intron of Commd1, and the Zrsr1 promoter resides in a differentially methylated region (DMR) that is maternally methylated in the oocyte. However, a mechanism for
Externí odkaz:
https://doaj.org/article/0e9afd8b65274d37ab1f9dd90aa58568
Autor:
Kentaro Mochizuki, Yohei Hayashi, Tamotsu Sekinaka, Kei Otsuka, Yumi Ito-Matsuoka, Hisato Kobayashi, Shinya Oki, Asuka Takehara, Tomohiro Kono, Noriko Osumi, Yasuhisa Matsui
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2682-2693.e6 (2018)
Summary: Primordial germ cells (PGCs) are fate determined from pluripotent epiblasts. Signaling pathways and transcriptional regulators involved in PGC formation have been identified, but detailed molecular mechanisms of PGC fate determination remain
Externí odkaz:
https://doaj.org/article/b036554b277c48b3b345372dd82b7e12
Autor:
Ippei Nagamori, Hisato Kobayashi, Yusuke Shiromoto, Toru Nishimura, Satomi Kuramochi-Miyagawa, Tomohiro Kono, Toru Nakano
Publikováno v:
Cell Reports, Vol 12, Iss 10, Pp 1541-1547 (2015)
De novo DNA methylation of retrotransposons is critical for silencing. Here, we use DNA methylation analysis to examine retrotransposons in mouse male germ cells. DNA methylation of long interspersed nuclear elements (LINEs) is dependent on piRNA, an
Externí odkaz:
https://doaj.org/article/5bc7844ea10e4f50a3330e5be5e2915c