Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tomohiro Iba"'
Autor:
Fitriana N. Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia, Nobuyuki Takakura
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been characterized, nor has
Externí odkaz:
https://doaj.org/article/8a70438de9cb43258fd801f999c3a70e
Autor:
Zheng Jing, Tomohiro Iba, Hisamichi Naito, Pingping Xu, Jun-ichi Morishige, Naoto Nagata, Hironao Okubo, Hitoshi Ando
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse reac
Externí odkaz:
https://doaj.org/article/76966174080b4fab9b0e1fa79fc45ca8
Autor:
Yohei Tsukada, Fumitaka Muramatsu, Yumiko Hayashi, Chiaki Inagaki, Hang Su, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditi
Externí odkaz:
https://doaj.org/article/3dc28d15ce0443be96af6006545bcfeb
Autor:
Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura
Publikováno v:
Inflammation and Regeneration, Vol 39, Iss 1, Pp 1-8 (2019)
Abstract Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell properties because o
Externí odkaz:
https://doaj.org/article/f2c038482d5945bab51c15e4ea9b213b
Autor:
Kazuhiro Takara, Daisuke Eino, Koji Ando, Daisuke Yasuda, Hisamichi Naito, Yohei Tsukada, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Shigetomo Fukuhara, Naoki Mochizuki, Satoshi Ishii, Haruhiko Kishima, Nobuyuki Takakura
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2072-2086 (2017)
Vascular normalization in tumors may improve drug delivery and anti-tumor immunity. Angiogenesis inhibitors induce hypoxia, which may facilitate malignant progression; therefore, we investigated other methods to promote vascular maturation. Here, we
Externí odkaz:
https://doaj.org/article/812d1475ee78429d99eb5acd0194da19
Autor:
Nobuyuki Takakura, Tomohiro Iba, Keitaro Yamane, Daisuke Eino, Kazuhiro Takara, Fumitaka Muramatsu, Hiroyasu Kidoya, Taku Wakabayashi, Hisamichi Naito
Angiogenesis plays a crucial role in tumor growth, with an undisputed contribution of resident endothelial cells (EC) to new blood vessels in the tumor. Here, we report the definition of a small population of vascular-resident stem/progenitor–like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b972350912a583bf106e811617a160d4
https://doi.org/10.1158/0008-5472.c.6508070.v1
https://doi.org/10.1158/0008-5472.c.6508070.v1
Autor:
Nobuyuki Takakura, Haruhiko Kishima, Kazuhiro Takara, Yasunori Fujimoto, Naoki Kagawa, Hideyuki Arita, Hiroyasu Kidoya, Fumitaka Muramatsu, Taku Wakabayashi, Tomohiro Iba, Yonehiro Kanemura, Hisamichi Naito, Yohei Tsukada, Daisuke Eino
The structure and function of tumor blood vessels profoundly affects the tumor microenvironment. Signals mediated through the lysophosphatidic acid receptor 4 (LPA4) promote vascular network formation to restore normal vascular barrier function in su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f19d7f4fcae5bbd84bdd2e265d379da
https://doi.org/10.1158/0008-5472.c.6510116.v1
https://doi.org/10.1158/0008-5472.c.6510116.v1
Autor:
Nobuyuki Takakura, Haruhiko Kishima, Kazuhiro Takara, Yasunori Fujimoto, Naoki Kagawa, Hideyuki Arita, Hiroyasu Kidoya, Fumitaka Muramatsu, Taku Wakabayashi, Tomohiro Iba, Yonehiro Kanemura, Hisamichi Naito, Yohei Tsukada, Daisuke Eino
Supplementary Figure 1. Coverage of pericyte and the basal membrane by LPA. Expression of LPA4 in several tumors. Supplementary Figure 2. Survival of wild-type and LPA4-KO mice harboring LLC brain tumors treated with or without LPA in the presence or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3c3a725991b523b5aa3ae620bbe4d2
https://doi.org/10.1158/0008-5472.22418390.v1
https://doi.org/10.1158/0008-5472.22418390.v1
Autor:
Nobuyuki Takakura, Tomohiro Iba, Keitaro Yamane, Daisuke Eino, Kazuhiro Takara, Fumitaka Muramatsu, Hiroyasu Kidoya, Taku Wakabayashi, Hisamichi Naito
Supplementary figure legend for supplementary figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098db08b14f50f70df926d9371465279
https://doi.org/10.1158/0008-5472.22410788
https://doi.org/10.1158/0008-5472.22410788
Autor:
Nobuyuki Takakura, Tomohiro Iba, Keitaro Yamane, Daisuke Eino, Kazuhiro Takara, Fumitaka Muramatsu, Hiroyasu Kidoya, Taku Wakabayashi, Hisamichi Naito
EC-SP and -MP cells are in the active phase of the cell cycle in the tumor microenvironment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9029f7750c69542b29f69fe5a09873ee
https://doi.org/10.1158/0008-5472.22410791
https://doi.org/10.1158/0008-5472.22410791