Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Tomohiro, Sawa"'
Autor:
Stephen Lindahl, Meg Shieh, Tianli Zhang, Chunyu Guo, Jerome R. Robinson, Tomohiro Sawa, Ming Xian
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103045- (2024)
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, the compounds that are suitable for biological investigations are limited to cysteine- and glutathione-derived polysul
Externí odkaz:
https://doaj.org/article/1f7d911ecf2242d9931cb7e2b5003850
Autor:
Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine per
Externí odkaz:
https://doaj.org/article/1a6db92f44634602affb96764e95005a
Autor:
Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack. Serine O-acetyltransferase (CysE) is an enzyme in many bacteria that c
Externí odkaz:
https://doaj.org/article/244b49b9ab684654afb3f2435e33f014
Autor:
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102834- (2023)
The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype. T
Externí odkaz:
https://doaj.org/article/1e2bbb9c5dc94ce59204c8ddd01abb95
Autor:
Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida, Yu Ishima
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 128 (2024)
Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress
Externí odkaz:
https://doaj.org/article/2036b9c136154d30b06052a027f4c553
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101741- (2022)
Summary: Infection of mice with Citrobacter rodentium is a useful model for studying the pathogenicity of enteropathogenic and enterohemorrhagic Escherichia coli, pathogens that have a close association with humans. Here, we provide a protocol detail
Externí odkaz:
https://doaj.org/article/f36060513e2f48ac99f5b9268442e4f7
Autor:
Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Accumulating evidence suggests that high levels of Fusobacterium nucleatum in colorectal tumor tissues can be associated with poor prognosis in patients with colorectal cancer (CRC); however, data regarding distinct prognostic subgroups in F. nucleat
Externí odkaz:
https://doaj.org/article/c71c3d7d698a4943bc0c2d530da4aca7
Autor:
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Katsuhiko Ono, Yukio Fujiwara, Sunao Iyoda, Fan-Yan Wei, Kazuaki Monde, Kazuko Seto, Makoto Ohnishi, Hiroyuki Oshiumi, Takaaki Akaike, Tomohiro Sawa
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104050- (2022)
Summary: Subtilase cytotoxin (SubAB) is an AB5 toxin mainly produced by the locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli (STEC) strain such as O113:H21, yet the contribution of SubAB to STEC infectious disease is unclear.
Externí odkaz:
https://doaj.org/article/5a42395178624e25b36725b46c736b1c
Autor:
Tomohiro Sawa, Takaaki Akaike
Publikováno v:
eLife, Vol 11 (2022)
The spike protein of SARS-CoV-2 triggers macrophages and epithelial cells to produce excess levels of pro-inflammatory molecules, which can do more harm than good.
Externí odkaz:
https://doaj.org/article/b972280d1f144c58b902efaff878da8a
Autor:
Tianli Zhang, Hiroyasu Tsutsuki, Waliul Islam, Katsuhiko Ono, Kohsuke Takeda, Takaaki Akaike, Tomohiro Sawa
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101930- (2021)
The NLRP3 inflammasome is a multiprotein complex responsible for the maturation of precursor forms of interleukin (IL)-1β and IL-18 into active proinflammatory cytokines. Increasing evidence suggests that modulation of redox homeostasis contributes
Externí odkaz:
https://doaj.org/article/530f6f5d9fca453385eb15653b28e95b