Zobrazeno 1 - 10
of 390
pro vyhledávání: '"Tomohiro, Kurosaki"'
Autor:
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor L. J. Tybulewicz, Antal Rot, Anja E. Hauser, Menna R. Clatworthy, Kai-Michael Toellner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to pot
Externí odkaz:
https://doaj.org/article/1cb0d96134a549388a75aab8fcbbbcaf
Autor:
Shasha Li, Michael D Bern, Benpeng Miao, Changxu Fan, Xiaoyun Xing, Takeshi Inoue, Sytse J Piersma, Ting Wang, Marco Colonna, Tomohiro Kurosaki, Wayne M Yokoyama
Publikováno v:
eLife, Vol 11 (2022)
BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune cells, such as natural killer (NK) cells.
Externí odkaz:
https://doaj.org/article/4803a607778c48e2a158ffe3d291b821
Autor:
Tom Sidwell, Yang Liao, Alexandra L. Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P. Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R. Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K. Smyth, Wei Shi, Axel Kallies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA
Externí odkaz:
https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells. Recent data have reinforced the importance of memory B cells, particularly in response to r
Externí odkaz:
https://doaj.org/article/8734273ffffe4d579d5ef16f54dbae4f
Autor:
Yu Adachi, Keisuke Tonouchi, Arnone Nithichanon, Masayuki Kuraoka, Akiko Watanabe, Ryo Shinnakasu, Hideki Asanuma, Akira Ainai, Yusuke Ohmi, Takuya Yamamoto, Ken J. Ishii, Hideki Hasegawa, Haruko Takeyama, Ganjana Lertmemongkolchai, Tomohiro Kurosaki, Manabu Ato, Garnett Kelsoe, Yoshimasa Takahashi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in
Externí odkaz:
https://doaj.org/article/fcc9b042359d4d5ca91778a784a13526
Autor:
Kentaro Inoue, Tomoharu Yasuda, Yoshihiro Baba, Tadashi Yamamoto, Tomohiro Kurosaki, Hisaaki Shinohara
Publikováno v:
Genes to Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::191f16c8b189f3353e7a9d8c7a7a9dd3
https://doi.org/10.1111/gtc.13022
https://doi.org/10.1111/gtc.13022
Autor:
Qizhi Liu, Eiji Umemoto, Naoki Morita, Hisako Kayama, Yoshihiro Baba, Tomohiro Kurosaki, Ryu Okumura, Kiyoshi Takeda
Publikováno v:
International Immunology. 34:343-352
CX3CR1high myeloid cells in the small intestine mediate the induction of oral tolerance by driving regulatory T (Treg) cells. Bacterial metabolites, e.g. pyruvate and lactate, induce a dendrite extension of CX3CR1high myeloid cells into the intestina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2816dadd72b98276b52003e6211c2461
https://doi.org/10.1093/intimm/dxac010
https://doi.org/10.1093/intimm/dxac010
Autor:
Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as
Externí odkaz:
https://doaj.org/article/f1cf2521c0344d9887bd758bdb76df35
Autor:
Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by whic
Externí odkaz:
https://doaj.org/article/46c2c5dacb5943f286af54fec57af3ac
Autor:
Yuhsuke Ohmi, Wataru Ise, Akira Harazono, Daisuke Takakura, Hidehiro Fukuyama, Yoshihiro Baba, Masashi Narazaki, Hirofumi Shoda, Nobunori Takahashi, Yuki Ohkawa, Shuting Ji, Fumihiro Sugiyama, Keishi Fujio, Atsushi Kumanogoh, Kazuhiko Yamamoto, Nana Kawasaki, Tomohiro Kurosaki, Yoshimasa Takahashi, Koichi Furukawa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors sh
Externí odkaz:
https://doaj.org/article/626de5323ebb454892d4e77327d0fdec