Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Tomohiro, Kikuchi"'
Autor:
Ryo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits an immune-active tumor microenvironment (TME) compared to MMR proficient (pMMR)/microsatellite stable/Epstein-Barr virus-negative [EBV (−
Externí odkaz:
https://doaj.org/article/57decaa1a5db4788a29f6759405f3d95
Autor:
Akira Matsuishi, Shotaro Nakajima, Motonobu Saito, Katsuharu Saito, Satoshi Fukai, Hideaki Tsumuraya, Ryo Kanoda, Tomohiro Kikuchi, Azuma Nirei, Akinao Kaneta, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Activating antibody-dependent cellular cytotoxicity (ADCC) by targeting claudin-18 isoform 2 (CLDN18.2) using zolbetuximab, a monoclonal antibody against CLDN18.2, has been considered a promising novel therapeutic strategy for gastric cancer
Externí odkaz:
https://doaj.org/article/e8b0b52e782c4628902216379a95458f
Autor:
Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Harushi Mori, Takeharu Yoshikawa
Publikováno v:
Insights into Imaging, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Objectives To investigate the relationship between low kidney volume and subsequent estimated glomerular filtration rate (eGFR) decline in eGFR category G2 (60–89 mL/min/1.73 m2) population. Methods In this retrospective study, we evaluate
Externí odkaz:
https://doaj.org/article/8bbdfcebb2ae494fbce3ac907f680dc0
Autor:
Yuji Kashiwakura, Kazuhiro Endo, Atsushi Ugajin, Tomohiro Kikuchi, Shuji Hishikawa, Hitoyasu Nakamura, Yuko Katakai, Nemekhbayar Baatartsogt, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Shoji Yamazaki, Akihiro Kume, Harushi Mori, Naohiro Sata, Yoichi Sakata, Shin-ichi Muramatsu, Tsukasa Ohmori
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 502-514 (2023)
Gene therapy using adeno-associated virus (AAV)-based vectors has become a realistic therapeutic option for hemophilia. We examined the potential of a novel engineered liver-tropic AAV3B-based vector, AAV.GT5, for hemophilia B gene therapy. In vitro
Externí odkaz:
https://doaj.org/article/e60d3f3fd02c459c99665b37f69364fb
Capability of GPT-4V(ision) in the Japanese National Medical Licensing Examination: Evaluation Study
Autor:
Takahiro Nakao, Soichiro Miki, Yuta Nakamura, Tomohiro Kikuchi, Yukihiro Nomura, Shouhei Hanaoka, Takeharu Yoshikawa, Osamu Abe
Publikováno v:
JMIR Medical Education, Vol 10, p e54393 (2024)
BackgroundPrevious research applying large language models (LLMs) to medicine was focused on text-based information. Recently, multimodal variants of LLMs acquired the capability of recognizing images. ObjectiveWe aim to evaluate the image recogniti
Externí odkaz:
https://doaj.org/article/13b1a2e3ed334efda317212be5d936d4
Autor:
Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Ashraful Alam, Harushi Mori, Naoto Hayashi
Publikováno v:
European Thyroid Journal, Vol 12, Iss 1, Pp 1-10 (2023)
Objective: This study aimed to determine a standardized cut-off value for abnormal 18F-fluorodeoxyglucose (FDG) accumulation in the thyroid gland. Methods: Herein, 7013 FDG–PET/CT scans were included. An automatic thy roid segmentation method using
Externí odkaz:
https://doaj.org/article/5da24835113847389086e9a0d29fa1ed
Autor:
Hisaichi Shibata, Shouhei Hanaoka, Takahiro Nakao, Tomohiro Kikuchi, Yuta Nakamura, Yukihiro Nomura, Takeharu Yoshikawa, Osamu Abe
Publikováno v:
Applied Sciences, Vol 14, Iss 8, p 3489 (2024)
Local differential privacy algorithms combined with deep generative models can enhance secure medical image sharing among researchers in the public domain without central administrators; however, these images were limited to the generation of low-res
Externí odkaz:
https://doaj.org/article/ba18df91de9f40e7bb1a09e6b53a0e5f
Autor:
Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Md Ashraful Alam, Harushi Mori, Naoto Hayashi
Publikováno v:
Life, Vol 13, Iss 12, p 2303 (2023)
This study aimed to explore the relationship between thyroid-stimulating hormone (TSH) elevation and the baseline computed tomography (CT) density and volume of the thyroid. We examined 86 cases with new-onset hypothyroidism (TSH > 4.5 IU/mL) and 107
Externí odkaz:
https://doaj.org/article/e78f14ed604b40ea9793bb05aa8b205a
Autor:
Masashi Endo, MD, Hiroyuki Fujii, MD, PhD, Akifumi Fujita, MD, PhD, Tatsuya Takayama, MD, PhD, Daisuke Matsubara, MD, PhD, Tomohiro Kikuchi, MD, Saki Manaka, MD, Harushi Mori, MD, PhD
Publikováno v:
Radiology Case Reports, Vol 17, Iss 3, Pp 619-622 (2022)
Ectopic adrenocortical tissue can arise along the path of embryonic migration, such as the celiac axis, broad ligament, adnexa of the testis, and spermatic cord. Occasionally, ectopic adrenocortical tissues undergo marked hyperplasia and develop into
Externí odkaz:
https://doaj.org/article/bbfaa3bd9456489f8eb401db98d5edf1
Autor:
Hiroki Yamamoto, Yuki Fukasawa, Yu Shoji, Shumpei Hisamoto, Tomohiro Kikuchi, Atsuko Takamatsu, Hideo Iwasaki
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Bacteria have been reported to exhibit complicated morphological colony patterns on solid media, depending on intracellular, and extracellular factors such as motility, cell propagation, and cell-cell interaction. We isolated the
Externí odkaz:
https://doaj.org/article/e72859c308c14938a27844f6ca1db9ed