Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Tomohiko SASASE"'
Autor:
Tetsuya Hasegawa, Rina Takagi, Yoshiaki Tanaka, Takeshi Ohta, Masami Shinohara, Yasushi Kageyama, Tomohiko Sasase, Shin-ichi Muramatsu, Toshikatsu Kaburaki, Akihiro Kakehashi
Publikováno v:
Biomedicine Hub, Vol 7, Iss 3, Pp 106-114 (2022)
Purpose: The aim of this study was to investigate the effects of different anesthetic agents on electroretinograms (ERGs) in Spontaneously Diabetic Torii fatty rats (SDT fatty rats). Methods: The ERG recordings were measured under general anesthesia
Externí odkaz:
https://doaj.org/article/fae2b9784e5644a1bb07534f54d4ec4f
Autor:
Kasumi Kikuchi, Miyuki Murata, Kousuke Noda, Satoru Kase, Yoshiaki Tagawa, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Susumu Ishida
Publikováno v:
Journal of Diabetes Research, Vol 2020 (2020)
Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity. SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formatio
Externí odkaz:
https://doaj.org/article/ea2169e889494e3e9022f4739742d812
Autor:
Yoshiaki Tanaka, Rina Takagi, Takeshi Ohta, Tomohiko Sasase, Mina Kobayashi, Fumihiko Toyoda, Machiko Shimmura, Nozomi Kinoshita, Hiroko Takano, Akihiro Kakehashi
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Objective. The Spontaneously Diabetic Torii (SDT) fatty rat, established by introducing the fa allele (obesity gene) of the Zucker fatty rat into the SDT rat genome, is a new model of obese type 2 diabetes. We studied the pathologic features of diabe
Externí odkaz:
https://doaj.org/article/16bc226c4ad34669af1beadc22114e32
Publikováno v:
International Journal of Endocrinology, Vol 2019 (2019)
Externí odkaz:
https://doaj.org/article/6bf01368687041898e110a19e1f61da9
Autor:
Yasuko Mera, Takashi Kawai, Naoto Ogawa, Naoya Odani, Tomohiko Sasase, Katsuhiro Miyajima, Takeshi Ohta, Makoto Kakutani
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 3, Pp 169-176 (2015)
JTT-130 was developed as an intestine-specific MTP inhibitor designed to rapidly catabolize after absorption to avoid causing hepatotoxicity due to hepatic MTP inhibition. In previous reports, we have demonstrated that JTT-130 suppresses dietary lipi
Externí odkaz:
https://doaj.org/article/6df01a5e373a4bec90a5262d41be7782
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
Externí odkaz:
https://doaj.org/article/0cbc090671ea4fb59626aa22585e058a
Autor:
Yusuke Kemmochi, Katsuhiro Miyajima, Takeshi Ohta, Tomohiko Sasase, Yuzo Yasui, Kaoru Toyoda, Kochi Kakimoto, Toshiyuki Shoda, Akihiro Kakehashi
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
We report uveitis observed in an obese type 2 diabetes rat model, Spontaneously Diabetic Torii Leprfa (SDT fatty) rats aged over 50 weeks. The eyes of SDT fatty rats (16 animals: 7 males and 9 females with 50 or 60 weeks of age) were examined histopa
Externí odkaz:
https://doaj.org/article/e174ce5b50dc4fa6ad51e87550e0d86e
Autor:
Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. Male Zucker diabetic fatty (ZDF) rats were divided into control, JTT-130 treatment, and pair-fed grou
Externí odkaz:
https://doaj.org/article/24bb51ceba1848a29d5cd79522e98b65
Autor:
Takeshi Ohta, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong, Takahisa Yamada
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
The Spontaneously Diabetic Torii Leprfa (SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities an
Externí odkaz:
https://doaj.org/article/1b6e387d709a4a8a9fa9bd216be79774
Autor:
Tomohiko Sasase, Takeshi Ohta, Taku Masuyama, Norihide Yokoi, Akihiro Kakehashi, Masami Shinohara
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D). Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks. Male SDT rats s
Externí odkaz:
https://doaj.org/article/2eed30fd9178418488e3ec38c494b190