Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Tomohide TAKAYA"'
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 709 (2024)
De-differentiation and subsequent increased proliferation and inflammation of vascular smooth muscle cells (VSMCs) is one of the mechanisms of atherogenesis. Maintaining VSMCs in a contractile differentiated state is therefore a promising therapeutic
Externí odkaz:
https://doaj.org/article/90acf1fa022947ad90d48255a8c8b9c3
Autor:
Koji Umezawa, Rena Ikeda, Taiichi Sakamoto, Yuya Enomoto, Yuma Nihashi, Sayaka Shinji, Takeshi Shimosato, Hiroshi Kagami, Tomohide Takaya
Publikováno v:
BioTech, Vol 13, Iss 2, p 11 (2024)
A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5′-AGA TTA GGG TGA GGG TGA-3′), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid dru
Externí odkaz:
https://doaj.org/article/17242a6b91614fc2a71b427d78c59071
Publikováno v:
The Journal of Poultry Science, Vol 58, Iss 2, Pp 79-87 (2021)
Skeletal muscle myoblasts are myogenic precursor cells that generate myofibers during muscle development and growth. We recently reported that broiler myoblasts, compared to layer myoblasts, proliferate and differentiate more actively and promptly in
Externí odkaz:
https://doaj.org/article/1cb4c7dfa76a459d83e746a2c9f4b059
Autor:
Naoki Nohira, Sayaka Shinji, Shunichi Nakamura, Yuma Nihashi, Takeshi Shimosato, Tomohide Takaya
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2691 (2022)
Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving as anti-nucleolin aptamers, have been reported to inhibit the proliferation and in
Externí odkaz:
https://doaj.org/article/3ee51c669a984b00a416f3312ddf18b3
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Skeletal muscle wasting in patients with diabetes mellitus (DM) is a complication of decreased muscle mass and strength, and is a serious risk factor that may result in mortality. Deteriorated differentiation of muscle precursor cells, called myoblas
Externí odkaz:
https://doaj.org/article/e05a08e193f34236a3e14ab3fd4ca334
Publikováno v:
Nanomaterials, Vol 12, Iss 10, p 1680 (2022)
Dysfunction of bone-forming cells, osteoblasts, is one of the causes of osteoporosis. Accumulating evidence has indicated that oligodeoxynucleotides (ODNs) designed from genome sequences have the potential to regulate osteogenic cell fate. Such osteo
Externí odkaz:
https://doaj.org/article/c126998845944ec3800f5e9de803d5e7
Autor:
Sayaka Shinji, Koji Umezawa, Yuma Nihashi, Shunichi Nakamura, Takeshi Shimosato, Tomohide Takaya
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Herein we report that the 18-base telomeric oligodeoxynucleotides (ODNs) designed from the Lactobacillus rhamnosus GG genome promote differentiation of skeletal muscle myoblasts which are myogenic precursor cells. We termed these myogenetic ODNs (myo
Externí odkaz:
https://doaj.org/article/df0305a94b864bd587b3490d0157ecca
Autor:
Marina Hosotani, Takeshi Kawasaki, Yasuhiro Hasegawa, Yui Wakasa, Maki Hoshino, Naoki Takahashi, Hiromi Ueda, Tomohide Takaya, Tomohito Iwasaki, Takafumi Watanabe
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Wooden breast syndrome (WB) constitutes an emerging myopathy in the pectoralis major muscle (PM) of broiler chickens, characterized by myofiber hypertrophy and degeneration along with severe fibrosis. WB pathogenesis has been considered to involve hy
Externí odkaz:
https://doaj.org/article/18c0dbfce26d47868b0b73b9cd9f6858
Autor:
Hiromichi Wada, Shuichi Ura, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Toshinori Murayama, Masayuki Yokode, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29351 (2011)
The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A (VEGF-A) plays a key role. On the other hand, vascular endothelial growth factor-C
Externí odkaz:
https://doaj.org/article/76bf549c3929436993e223b0ecd1c549
Publikováno v:
Biochemical and biophysical research communications. 664:1-8
A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated from patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00aaccdaa16b60bba3dcd370a51a71e7
https://soar-ir.repo.nii.ac.jp/records/2001447
https://soar-ir.repo.nii.ac.jp/records/2001447