Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Tomohide Hosokawa"'
Autor:
Keiichi Higuchi, Masanori Hosokawa, Eiko Toichi, Masamichi Hosono, Takatoshi Matsushita, Tomohide Hosokawa
Publikováno v:
International Congress Series. 1260:357-361
SAMP1 mice show impaired immune activity as young adults and suffer from senile amyloidosis due to Apoa2 gene expression at around a year of age, and this factor may be responsible for their short life. To examine the relationship between low immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0291d41a095233cbd1b7c963654f738a
https://doi.org/10.1016/s0531-5131(03)01688-1
https://doi.org/10.1016/s0531-5131(03)01688-1
Publikováno v:
International Congress Series. 1260:203-207
We investigated the regulatory effects of noradrenalin (NA) and corticosterone (CS) on the antibody-forming response against ovalbumin (OVA) of cultured mouse spleen cells. SAMP1 and C3H/He mice were immunized with two intraperitoneal injections of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7146d3bdbcbe39da1ecfdbaabf781d3e
https://doi.org/10.1016/s0531-5131(03)01581-4
https://doi.org/10.1016/s0531-5131(03)01581-4
Publikováno v:
International Congress Series. 1260:209-213
SAMP1 and C3H/He mice were immunized with one or two intraperitoneal injections of ovalbumin (OVA) with alum adjuvant. Spleen cells from immunized as well as unprimed naive mice were cultured with OVA for 7 or 14 days. We observed little anti-OVA ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f877a22d0e1b4f7209154aba9def04a1
https://doi.org/10.1016/s0531-5131(03)01569-3
https://doi.org/10.1016/s0531-5131(03)01569-3
Autor:
Tomohide Hosokawa
Publikováno v:
International Congress Series. 1260:41-46
The immune system in SAMP strains shows signs of early senescence in various functional aspects. Interestingly, cultured spleen cells from mice of SAMP strains with the major histocompatibility complex (MHC) haplotype of H-2 k showed an impaired anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ffc1a1a8e03bd199c044be4600a627
https://doi.org/10.1016/s0531-5131(03)01565-6
https://doi.org/10.1016/s0531-5131(03)01565-6
Publikováno v:
International Congress Series. 1260:199-202
We compared the time course of the stress-induced morphological changes in the thymus between SAMP1 and C3H/He mice. The mice were kept under restraint in a 50-ml plastic centrifuge tube in water at 24° for 4 h. This treatment induced atrophy of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ab36b015f2808bc228942547df48ad
https://doi.org/10.1016/s0531-5131(03)01568-1
https://doi.org/10.1016/s0531-5131(03)01568-1
Publikováno v:
International Congress Series. 1260:215-219
We studied the regulatory effects of noradrenaline (NA) on antibody and cytokine production in cultured SAMP1 spleen cells stimulated with ovalbumin (OVA), a T-dependent antigen. SAMP1 and C3H/He mice were immunized with an intraperitoneal injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ef0729cafc55b77a74dab9eb886c51
https://doi.org/10.1016/s0531-5131(03)01693-5
https://doi.org/10.1016/s0531-5131(03)01693-5
Autor:
Mitsuo Baba, Masanori Hosokawa, Hiroshi Iguchi, Masamichi Hosono, Yasumitsu Nishimura, Tomohide Hosokawa
Publikováno v:
International Congress Series. 1260:221-225
SAMP1 mice show markedly low T-dependent antibody-producing responses. Recently, we demonstrated that splenic CD4 + T cells from SAMP1 mice show abnormally short-lasting production of interleukin (IL)-2, leading to the impaired proliferation and surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aaef7bdeec385f6a3121f7dfb233941
https://doi.org/10.1016/s0531-5131(03)01570-x
https://doi.org/10.1016/s0531-5131(03)01570-x
Publikováno v:
Immunology. 107:190-198
SUMMARY We examined the proliferative and cytokine-producing activities of CD4 þ T cells from young mice of the senescence-accelerated mouse strain SAMP1, which had shown markedly low T-dependent antibody-producing responses. When splenic T cells we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4209d5b801c15e811128439e4b9e2d
https://doi.org/10.1046/j.1365-2567.2002.01496.x
https://doi.org/10.1046/j.1365-2567.2002.01496.x
Autor:
Masamichi Hosono, Keiichi Higuchi, Tomohide Hosokawa, Eiko Toichi, Zhanjun Guo, Masanori Hosokawa, Masayuki Mori
Publikováno v:
Mechanisms of Ageing and Development. 118:35-44
The SAMP1 mouse, a senescence-accelerated mouse prone (SAMP) strain, shows accelerated senescence coupled with a short lifespan as a genetic trait, and has been used in gerontological research. The accelerated senescence and short lifespan of SAMP st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677597f2aef8551b5cb49a6b879806be
https://doi.org/10.1016/s0047-6374(00)00148-2
https://doi.org/10.1016/s0047-6374(00)00148-2
Autor:
Tomohide Hosokawa, Masamichi Hosono, Sadao Imamura, Eiko Toichi, K Hanada, Keiichi Higuchi, Masanori Hosokawa
Publikováno v:
Mechanisms of Ageing and Development. 99:199-217
We investigated the cellular basis of the age-related decline in antibody (Ab) and delayed-type hypersensitivity (DTH) responses to sheep red blood cells (SRBC) in vivo in short-lived senescence-accelerated mouse (SAM) P1. In SAMP1 mice, age-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabffdfabc58e45764117103aef4f02b
https://doi.org/10.1016/s0047-6374(97)00100-0
https://doi.org/10.1016/s0047-6374(97)00100-0