Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tomohide Hayami"'
Autor:
Masahiro Yamaguchi, Saeko Noda-Asano, Rieko Inoue, Tatsuhito Himeno, Mikio Motegi, Tomohide Hayami, Hiromi Nakai-Shimoda, Ayumi Kono, Sachiko Sasajima, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Jiro Nakamura, Hideki Kamiya
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8881 (2024)
Individuals suffering from diabetic polyneuropathy (DPN) experience debilitating symptoms such as pain, paranesthesia, and sensory disturbances, prompting a quest for effective treatments. Dipeptidyl-peptidase (DPP)-4 inhibitors, recognized for their
Externí odkaz:
https://doaj.org/article/2821cd4386b145ecbe325e1e384325a8
Autor:
Sachiko Sasajima, Masaki Kondo, Nobuhiko Ohno, Tomoyo Ujisawa, Mikio Motegi, Tomohide Hayami, Saeko Asano, Emi Asano-Hayami, Hiromi Nakai-Shimoda, Rieko Inoue, Yuichiro Yamada, Emiri Miura-Yura, Yoshiaki Morishita, Tatsuhito Himeno, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Makoto Tominaga
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Diabetic peripheral neuropathy (DPN) includes symptoms of thermosensory impairment, which are reported to involve changes in the expression or function, or both, of nociceptive TRPV1 and TRPA1 channels in rodents. In the present study, we di
Externí odkaz:
https://doaj.org/article/6fa6fde098624c8097f825048009b79a
Autor:
Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada‐Yamada, Yusuke Hayashi, Emi Asano‐Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hiromi Nakai‐Shimoda, Takahiro Ishikawa, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Takayuki Nakayama, Motohiro Kamei, Jiro Nakamura, Hideki Kamiya
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1430-1441 (2021)
Abstract Aims/Introduction Diabetic polyneuropathy (DPN) and diabetic retinopathy (DR) are traditionally regarded as microvascular complications. However, these complications may share similar neurodegenerative pathologies. Here we evaluate the corre
Externí odkaz:
https://doaj.org/article/1a93ea39dc48466fab085a903c5af8a0
Autor:
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Mikio Motegi, Norio Ozeki, Rieko Inoue, Tomohide Hayami, Emiri Miura-Yura, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Masaki Kondo, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101591- (2022)
Summary: Morphological analysis of peripheral nerves in mouse models can be used to characterize the pathophysiology of peripheral nerve disease, but obtaining high-quality electron micrographs can be challenging. Here, we present a protocol to obtai
Externí odkaz:
https://doaj.org/article/67480149bc814bc88447853f6a51127f
Autor:
Tomohide Hayami, Norihide Yokoi, Takuro Yamaguchi, Kohei Honda, Naoya Murao, Harumi Takahashi, Shujie Wang, Yusuke Seino, Hideki Kamiya, Daisuke Yabe, Ian R Sweet, Akira Mizoguchi, Jiro Nakamura, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1434-1447 (2020)
Abstract Aims/Introduction Pancreatic islets are heterogenous. To clarify the relationship between islet heterogeneity and incretin action in the islets, we studied gene expression and metabolic profiles of non‐large and enlarged islets of the Zuck
Externí odkaz:
https://doaj.org/article/5890f1d6c1da4df0a98ae5c4ae59e065
Autor:
Naoya Murao, Norihide Yokoi, Harumi Takahashi, Tomohide Hayami, Yasuhiro Minami, Susumu Seino
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101414- (2022)
Objective: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D. Methods: We used senescence-accelerated mice (SAM), C57BL/6J (B6) mice, and ob/ob mice a
Externí odkaz:
https://doaj.org/article/a3936d5cd61f4706a23b2a895c3b8b0d
Autor:
Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, Yoshitaka Hayashi, Hiroshi Arima
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 2, Pp 238-250 (2019)
Abstract Aims/Introduction A high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects β‐cell mass (BCM) has been little investigated. Materials and Methods Both
Externí odkaz:
https://doaj.org/article/a2e1437fe32748a49166a16dd0b6e4e0
Autor:
Saeko Asano, Tatsuhito Himeno, Tomohide Hayami, Mikio Motegi, Rieko Inoue, Hiromi Nakai-Shimoda, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Jiro Nakamura, Hideki Kamiya
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Distal sensory-motor polyneuropathy is one of the most frequent diabetic complications. However, few therapies address the etiology of neurodegeneration in the peripheral nervous systems of diabetic patients. Several metabolic mechanisms have been pr
Externí odkaz:
https://doaj.org/article/92565764ef2c4923829e40a620f80c3c
Autor:
Makoto Kato, Shin Tsunekawa, Nobuhisa Nakamura, Emiri Miura-Yura, Yuichiro Yamada, Yusuke Hayashi, Hiromi Nakai-Shimoda, Saeko Asano, Tomohide Hayami, Mikio Motegi, Emi Asano-Hayami, Sachiko Sasajima, Yoshiaki Morishita, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Takako Izumoto-Akita, Akihito Yamamoto, Keiko Naruse, Jiro Nakamura, Hideki Kamiya
Publikováno v:
Cells, Vol 9, Iss 11, p 2385 (2020)
Diabetes is a major risk factor for atherosclerosis and ischemic vascular diseases. Recently, regenerative medicine is expected to be a novel therapy for ischemic diseases. Our previous studies have reported that transplantation of stem cells promote
Externí odkaz:
https://doaj.org/article/01ad029b5d64497d83e71b3f9dc6b101
Autor:
Naoya Murao, Norihide Yokoi, Kohei Honda, Guirong Han, Tomohide Hayami, Ghupurjan Gheni, Harumi Takahashi, Kohtaro Minami, Susumu Seino
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187213 (2017)
Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical proce
Externí odkaz:
https://doaj.org/article/0d5dfbcc99b7490f811aac96ca1a34db