Výsledky vyhledávání - "Tomohide, Kurahashi"

Akademický článek

Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in MiceSummary

Autor: Tomohide Kurahashi, Yuichi Yoshida, Satoshi Ogura, Mayumi Egawa, Kunimaro Furuta, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Shinichi Kiso, Yoshihiro Kamada, I-Ching Wang, Hidetoshi Eguchi, Eiichi Morii, Yuichiro Doki, Masaki Mori, Vladimir V. Kalinichenko, Tomohide Tatsumi, Tetsuo Takehara

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)

Background & Aims: Liver inflammation has been recognized as a hallmark of hepatocarcinogenesis. Although Forkhead Box M1 (FoxM1) is a well-defined oncogenic transcription factor that is overexpressed in hepatocellular carcinoma (HCC), its role in li

Externí odkaz: https://doaj.org/article/5ba2358818af4cb5928d97ec632e1731

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Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis

Autor: Kazuhiro Murai, Katsuhiko Sato, Yasutoshi Nozaki, Tomohide Kurahashi, Takahiro Kodama, Sadatsugu Sakane, Hayato Hikita, Tetsuo Takehara, Ryotaro Sakamori, Yuto Shiode, Tomohide Tatsumi, Yuichi Yoshida, Naoki Mizutani, Makiko Urabe, Yoshinobu Saito, Yuta Myojin

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G958-G968

Grb2-associated binder 1 (Gab1) is an adaptor protein that is important for intracellular signal transduction by receptor tyrosine kinases that are receptors for various growth factors and plays an important role in rapid liver regeneration after par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a0f38630323dc3b53da238014af97b
https://doi.org/10.1152/ajpgi.00370.2020

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[A case of eosinophilic gastroenteritis caused after the use of Seprafilm

Autor: Takumi, Kinomoto, Takuya, Yamada, Yuhei, Wakahara, Tomohide, Kurahashi, Yukihiro, Kusumoto, Toshio, Yamaguchi, Yuka, Sueyoshi, Motohiro, Hirao, Atsushi, Hosui, Naoki, Hiramatsu

Publikováno v: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 119(5)

Eosinophilic gastroenteritis is a fairly uncommon condition. It has been suggested that allergic reactions may have played a role in the development of this illness. The case of a 66-year-old woman who had a total hysterectomy due to a right ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fb2def7ebf9bcbeb5bef80e544c20f3
https://pubmed.ncbi.nlm.nih.gov/35545545

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Exacerbation of non-steroidal anti-inflammatory drug-induced enteropathy in C-C chemokine receptor type 7-deficient mice

Autor: Toshio Yamaguchi, Hideki Iijima, Takeo Yoshihara, Mizuki Tani, Yuriko Otake, Shuko Iwatani, Takahiro Amano, Taku Tashiro, Tomohide Kurahashi, Takanori Inoue, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Daisuke Motooka, Shota Nakamura, Shinichiro Shinzaki, Tetsuo Takehara

Publikováno v: Journal of gastroenterology and hepatologyReferences. 37(8)

Non-steroidal anti-inflammatory drugs (NSAIDs) induce intestinal enteropathy and the pathophysiology is related to immune-mediated mechanisms. We aimed to investigate the role of C-C chemokine receptor type 7 (CCR7) which regulates immune cell migrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc90da9c0e0e1c87e8fd9f6d1680caa
https://pubmed.ncbi.nlm.nih.gov/35435994

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Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma

Autor: Mayumi Egawa, Hidetoshi Eguchi, Hayato Hikita, Kunimaro Furuta, Masaki Mori, Yoshihiro Kamada, Shinichi Kiso, Hisakazu Ogita, Tomohide Kurahashi, Satoshi Ogura, Yuichi Yoshida, Tetsuo Takehara, Yuichiro Doki, Tomohide Tatsumi

Publikováno v: Oncotarget

Dysregulation of cell metabolism is a hallmark of cancer. The mevalonate pathway in lipid metabolism has been implicated as a potential target of cancer therapy for hepatocellular carcinoma (HCC). The role of the Forkhead Box M1 (FoxM1) transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705ce4e743501d7ae8903dd3f571b271
https://pubmed.ncbi.nlm.nih.gov/29765517

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Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma

Autor: Mayumi, Egawa, Yuichi, Yoshida, Satoshi, Ogura, Tomohide, Kurahashi, Takashi, Kizu, Kunimaro, Furuta, Yoshihiro, Kamada, Norihiro, Chatani, Mina, Hamano, Shinichi, Kiso, Hayato, Hikita, Tomohide, Tatsumi, Hidetoshi, Eguchi, Hiroaki, Nagano, Yuichiro, Doki, Masaki, Mori, Tetsuo, Takehara

Publikováno v: Hepatology research : the official journal of the Japan Society of Hepatology. 47(11)

Forkhead Box M1 (FoxM1) is a proliferation-specific transcription factor. In this study, we aimed to elucidate the clinicopathological and prognostic values of FoxM1 expression in human hepatocellular carcinoma (HCC) and correlate FoxM1 expression wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92695b6379a2f791176d48510826cb73
https://pubmed.ncbi.nlm.nih.gov/28002884

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Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice

Autor: Kunimaro Furuta, Yoshihiro Kamada, Keigo Nishida, Norihiro Chatani, Mayumi Egawa, Tetsuo Takehara, Shinichiro Maeda, Shinichi Kiso, Yuichi Yoshida, Takashi Kizu, Tomohide Kurahashi, Satoshi Ogura, Yoshikazu Nakaoka

Publikováno v: Hepatology (Baltimore, Md.). 63(4)

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. In APAP-induced acute liver failure, hepatocyte death and subsequent liver regeneration determines the prognosis of patients, making it necessary to identify suit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f85150955f424c436ce93aaa161d64
https://pubmed.ncbi.nlm.nih.gov/26680679

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