Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tomoharu Osada"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 233-239 (2018)
Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM
Externí odkaz:
https://doaj.org/article/f8bba6ec3dca42b591e093427eda3612
Autor:
Ksenia Blinova, Qianyu Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua Rong Lu, Udo Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, Kohei Sawada, Tomoharu Osada, Yasunari Kanda, Yuko Sekino, Li Pang, Tromondae K. Feaster, Ralf Kettenhofen, Norman Stockbridge, David G. Strauss, Gary Gintant
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)
Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dr
Externí odkaz:
https://doaj.org/article/3766b15437f1454ca223759395ad3b34
Autor:
Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Tomoharu Osada, Seiji Hayashi, Chieko Kasai, Norimasa Miyamoto, Hiroyuki Tashibu, Takashi Yoshinaga, Daiju Yamazaki, Atsushi Sugiyama, Yasunari Kanda, Kohei Sawada, Yuko Sekino
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167348 (2016)
The aims of this study were to (1) characterize basic electrophysiological elements of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) that correspond to clinical properties such as QT-RR relationship, (2) determine the applica
Externí odkaz:
https://doaj.org/article/5b89cf1c65b04ff58b7beaa48cc3e498
Autor:
Tomoharu Osada, Hideki Ogino, Toshiaki Hino, Sachiyo Ichinose, Kenji Nakamura, Akira Omori, Toshiaki Noce, Mitsuko Masutani
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
BACKGROUND: During fertilization, pronuclear envelope breakdown (PNEB) is followed by the mingling of male and female genomes. Dynamic chromatin and protein rearrangements require posttranslational modification (PTM) for the postfertilization develop
Externí odkaz:
https://doaj.org/article/b4c231e732704522a463ccf55e1dec95
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 233-239 (2018)
Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM
Autor:
Tomoharu Osada, Yama A. Abassi, Hong Shi, Jennifer B. Pierson, Sonja Stoelzle-Feix, Gary Gintant, Qianyu Dang, T.K. Feaster, Emily Pfeiffer Kaushik, Hua Rong Lu, Todd J. Herron, Li Pang, Ksenia Blinova, Godfrey L. Smith, Martin Traebert, Beibei Cai, Yasunari Kanda, Ralf Kettenhofen, Francis L. Burton, Katherine Czysz
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 117
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the a
Publikováno v:
Current Protein & Peptide Science. 17:693-704
Accumulating evidence suggests that cloned mice production by the injection of a somatic cell nucleus into an enucleated oocyte is inefficient. DNA damage and chromatin remodeling failures that occur during embryogenesis following nuclear transfer (N
Autor:
Gary Gintant, Jennifer B. Pierson, Tomoharu Osada, Tromondae K. Feaster, Daniel C. Millard, David G. Strauss, Qianyu Dang, Hua Rong Lu, Yuko Sekino, Udo Kraushaar, Godfrey L. Smith, Yasunari Kanda, Ralf Kettenhofen, Ksenia Blinova, Norman Stockbridge, Kohei Sawada, Li Pang, Haoyu Zeng, Xiaoyu Zhang, Liang Guo, Mathew Brock, Hong Shi
Publikováno v:
Cell reports
Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)
Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)
SUMMARY To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fd4bc356bed5abb3ac2398a3d605eb
https://eprints.gla.ac.uk/171110/1/171110.pdf
https://eprints.gla.ac.uk/171110/1/171110.pdf
Publikováno v:
Biotechnology Progress. 30:1401-1410
Oxygen supply is a critical issue in the optimization of in vitro hepatocyte microenvironments. Although several strategies have been developed to balance complex oxygen requirements, these techniques are not able to accurately meet the cellular oxyg
Autor:
Tadashi Kadowaki, Tomoharu Osada, Takashi Yoshinaga, Tetsuo Kitamura, Norimasa Miyamoto, Atsuko Ojima
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:165-166