Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Tomoh Matsumiya"'
Autor:
Hidenori Umetsu, Shojiro Watanabe, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 46, Iss 2, Pp 207-218 (2021)
Background: Although toll-like receptor 3 (TLR3) signaling is involved in the development of certain chronic kidney diseases, the specific molecular mechanisms underlying inflammatory reactions via activation of TLR3 signaling in human podocytes rema
Externí odkaz:
https://doaj.org/article/ad09e26b2fea49c4819ed069b004b2c2
Autor:
Xu Liu, Zaiqiang Yu, Kazuyuki Daitoku, Ikuo Fukuda, Shigeru Motomura, Tomoh Matsumiya, Tadaatsu Imaizumi, Ken-Ichi Furukawa, Kazuhiko Seya
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 2, Pp 213-221 (2021)
Since aortic valve stenosis (AVS) is the most frequent and serious valvular heart disease in the elderly, and is accompanied by irreversible valve calcification, medicinal prevention of AVS is important. Although we recently demonstrated that human a
Externí odkaz:
https://doaj.org/article/a634f22a42784062a05da75f18d049a3
Autor:
Riko Sato, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Publikováno v:
Renal Failure, Vol 43, Iss 1, Pp 643-650 (2021)
Objective Although anti-malarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ) are currently used for the treatment of systemic lupus erythematosus, their efficacy for lupus nephritis (LN) remains unclear. Given that upregulation of glomerula
Externí odkaz:
https://doaj.org/article/dd186af8fa074bd6aaf1b9d29f6fabd3
Autor:
Tadaatsu Imaizumi, Shun Hashimoto, Riko Sato, Hidenori Umetsu, Tomomi Aizawa, Shojiro Watanabe, Shogo Kawaguchi, Tomoh Matsumiya, Kazuhiko Seya, Jiangli Ding, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-12 (2020)
Introduction: Various viruses including a novel coronavirus (SARS-CoV-2) can infect the kidney. When viruses invade the glomeruli from the bloodstream, glomerular endothelial cells (GECs) initiate the innate immune reactions. We investigated the expr
Externí odkaz:
https://doaj.org/article/1c95c3ab84dd46bb978657e048e8373d
Autor:
Qiang Liu, Tadaatsu Imaizumi, Tomomi Aizawa, Koji Hirono, Shogo Kawaguchi, Shojiro Watanabe, Koji Tsugawa, Tomoh Matsumiya, Kazuhiko Seya, Hidemi Yoshida, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 44, Iss 1, Pp 62-71 (2019)
Background/Aims: Dysregulation of interleukin-6 (IL-6) production in residual renal cells may play a pivotal role in the development of glomerulonephritis (GN). Given that Toll-like receptor 3 (TLR3) signaling has been implicated in the pathogenesis
Externí odkaz:
https://doaj.org/article/f29bddd9c2944d3da8c7f8d6ac7a8812
Autor:
Tadaatsu Imaizumi, Ryo Hayakari, Shojiro Watanabe, Tomomi Aizawa, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shogo Kawaguchi, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 42, Iss 5, Pp 942-950 (2017)
Background/Aims: Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/typ
Externí odkaz:
https://doaj.org/article/ab58063881874bf287ae45f29e82e488
Autor:
Tadaatsu Imaizumi, Chikashi Yano, Akiko Numata, Koji Tsugawa, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 635-642 (2016)
Background/Aims: Activation of Toll-like receptor 3 (TLR3) signaling followed by type I interferon (IFN) expression is crucial in antiviral and “pseudoviral” immune reactions in renal mesangial cells (MCs). These reactions are probably involved i
Externí odkaz:
https://doaj.org/article/a04283dd670a4d17a0fa46746d331ec0
Autor:
Fei Xing, Tomoh Matsumiya, Ryo Hayakari, Hidemi Yoshida, Shogo Kawaguchi, Ippei Takahashi, Shigeyuki Nakaji, Tadaatsu Imaizumi
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151173 (2016)
Genetic variation is associated with diseases. As a type of genetic variation occurring with certain regularity and frequency, the single nucleotide polymorphism (SNP) is attracting more and more attention because of its great value for research and
Externí odkaz:
https://doaj.org/article/c3ad70b3e4284247962dd88bdef29a1a
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168696 (2016)
Non-self RNA is recognized by retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), inducing type I interferons (IFNs). Type I IFN promotes the expression of IFN-stimulated genes (ISGs), which requires the activation of signal transducer and
Externí odkaz:
https://doaj.org/article/922b948a6d304bd780196cad08d23502
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163520 (2016)
The cytoplasmic viral sensor retinoic acid-inducible gene-I (RIG-I), which is also known as an IFN-stimulated gene (ISG), senses viral RNA to activate antiviral signaling. It is therefore thought that RIG-I is regulated in a STAT1-dependent manner. A
Externí odkaz:
https://doaj.org/article/aaaf54e9ced940cd82e5000bdf24ea3e