Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Tomoe Koga"'
1
A Novel Role for hGas7b in Microtubular Maintenance
Autor: Hiroyuki Arai, Aina Gotoh, Chiyoko Uchida, Ryong Woon Shin, Takafumi Uchida, Akira Sawa, Akihiro Harada, Tomoe Koga, Hirotada Akiyama, Tsubasa Ohashi, Wataru Sakamoto
Publikováno v: Journal of Biological Chemistry. 284:32695-32699
Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c637d75afb360400a2419adf35aa989c
https://doi.org/10.1074/jbc.m109.035998
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2
Direct Optical Microscopic Observation of the Microtubule Polymerization Intermediate Sheet Structure in the Presence of Gas7
Autor: Keiko Hirose, Tomohiko J. Itoh, Chiyoko Uchida, Kangmin Yan, Takafumi Uchida, Wataru Sakamoto, Tomoe Koga, Hirotada Akiyama
Publikováno v: Journal of Molecular Biology. 391:849-857
The process of microtubule elongation is thought to consist of two stages—formation of a tubulin sheet structure and its closure into a tube. However, real-time observation of this process has been difficult. Here, by utilizing phospho-tau binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743c008fbcd5774ea6e2f7060e65da77
https://doi.org/10.1016/j.jmb.2009.06.081
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3
Alzheimer's disease-related protein hGas7b interferes with kinesin motility
Autor: Masafumi Hidaka, Aina Gotoh, Tomoe Koga, Takafumi Uchida, Mariko Sanada, Keiko Hirose
Publikováno v: Journal of biochemistry. 151(6)
In the previous study, we reported the important properties of hGas7b (i) that binds to phospho-tau and facilitates microtubule polymerization and (ii) the level of hGas7b is very low in the brains of patients with Alzheimer's disease. These results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a7ae4c5899b3162633c6aa2cf5cbd3
https://pubmed.ncbi.nlm.nih.gov/22496485
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4
Relationship between the structures of taxane derivatives and their microtubule polymerization activity
Autor: Hiromasa Kiyota, Tomoe Koga, Keiko Hirose, Qing-Wen Shi, Tohru Horiguchi, Takafumi Uchida, Masafumi Hidaka
Publikováno v: Bioscience, biotechnology, and biochemistry. 76(2)
Paclitaxel (Taxol), one of the most potent anticancer drugs, is a microtubule-stabilizing compound that inhibits microtubule depolymerization within the cell. The structure of paclitaxel is composed of two key elements, a taxane ring and an N-benzoyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b39fe59cdd62bab4a4d7b9c46e7978
https://pubmed.ncbi.nlm.nih.gov/22313785
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5
A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease
Autor: Hirotada, Akiyama, Aina, Gotoh, Ryong-Woon, Shin, Tomoe, Koga, Tsubasa, Ohashi, Wataru, Sakamoto, Akihiro, Harada, Hiroyuki, Arai, Akira, Sawa, Chiyoko, Uchida, Takafumi, Uchida
Publikováno v: The Journal of biological chemistry. 284(47)
Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae3276f7e593e540878ebc2e94b64530
https://pubmed.ncbi.nlm.nih.gov/19801671
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