Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tomochika MATSUSHITA"'
Autor:
Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo, Chiyomi Kubo
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTherapeutic antibodies sometimes elicit anti-drug antibodies (ADAs) that can affect efficacy and safety. Engineered antibodies that contain artificial amino acid sequences are potentially highly immunogenic, but this is currently difficult to
Externí odkaz:
https://doaj.org/article/9c8b83e3cca74382a102aa8a0b0f06ad
Autor:
Nozomi FUJISAWA, Tomochika MATSUSHITA, Saori MATSUO, Mayumi HIRANUMA, Hiroko AZABU, Ryota SAITO, Shun-Ichiro KOMATSU, Atsuhiko KATO, Naoto TOYOTA, Junko TAKETO, Hiromi SUZUKI
Publikováno v:
Experimental Animals; 2024, Vol. 73 Issue 1, p73-82, 10p
Autor:
Tomoyuki Igawa, Takehisa Kitazawa, Yoshiki Kawabe, Kou-ichi Jishage, Mika Endo, Yoshito Nakanishi, Otoya Ueda, Atsuhiko Kato, Noriaki Sawada, Yasushi Tomii, Fumihisa Isomura, Masaki Kamimura, Tetsuya Wakabayashi, Ami Ito, Haruka Kuroi, Junko Shinozuka, Yuki Noguchi, Motohiko Sato, Yasuko Satoh, Nasa Savory, Sotaro Naoi, Koki Hamada, Ayano Hirako, Sayuri Horikawa, Akihisa Sakamoto, Shun-ichiro Komatsu, Shojiro Kadono, Tomochika Matsushita, Tetsushi Sakiyama, Kenji Adachi, Natsuki Ono, Tatsuhiko Tachibana, Hirofumi Mikami, Shun Shimizu, Yuki Ohte, Naoko A. Wada, Taro Miyazaki, Shoichi Metsugi, Meiri Shida-Kawazoe, Kenji Taniguchi, Naoka Hironiwa, Masaki Honda, Ryo Uchikawa, Takayuki Nemoto, Yuji Hori, Yoshinori Narita, Mika Kamata-Sakurai
Supplementary figures, tables, material and methods, and references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef075e9b136326aba4e8a3303859f52
https://doi.org/10.1158/2159-8290.22535753.v1
https://doi.org/10.1158/2159-8290.22535753.v1
Autor:
Tatsuhiko Tachibana, Nasa Savory, Otoya Ueda, Sayuri Horikawa, Tetsushi Sakiyama, Tomochika Matsushita, Yuji Hori, Kou-ichi Jishage, Haruka Kuroi, Motohiko Sato, Tetsuya Wakabayashi, Junko Shinozuka, Naoka Hironiwa, Meiri Shida-Kawazoe, Kenji Adachi, Ryo Uchikawa, Taro Miyazaki, Koki Hamada, Masaki Honda, Fumihisa Isomura, Mika Endo, Mika Kamata-Sakurai, Yoshito Nakanishi, Yuki Noguchi, Natsuki Ono, Yasuko Satoh, Yuki Ohte, Tomoyuki Igawa, Ayano Hirako, Hirofumi Mikami, Naoko A. Wada, Noriaki Sawada, Takehisa Kitazawa, Yasushi Tomii, Shun-ichiro Komatsu, Takayuki Nemoto, Yoshinori Narita, Kenji Taniguchi, Shun Shimizu, Naoi Sotaro, Akihisa Sakamoto, Shojiro Kadono, Yoshiki Kawabe, Atsuhiko Kato, Kamimura Masaki, Shoichi Metsugi, Ami Ito
Publikováno v:
Cancer Discovery. 11:158-175
Agonistic antibodies targeting CD137 have been clinically unsuccessful due to systemic toxicity. Because conferring tumor selectivity through tumor-associated antigen limits its clinical use to cancers that highly express such antigens, we exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70e3edd07d12527043287be739925bc
https://doi.org/10.1158/2159-8290.cd-20-0328
https://doi.org/10.1158/2159-8290.cd-20-0328
Autor:
Chie Kato, Tomochika Matsushita, Atsuhiko Kato, Etsuko Fujii, Masami Suzuki, Kenji Adachi, Takeshi Watanabe, Kaori Isobe
Publikováno v:
Journal of Toxicologic Pathology
Some therapeutic antibodies as anticancer agents exert their effects through the host immune system, but the factors that predict their cytotoxicity, including complement-dependent cytotoxicity (CDC), are unclear. In the present study, we attempted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a619977a5650306ccf5435802ab8854
https://doi.org/10.1293/tox.26.41
https://doi.org/10.1293/tox.26.41
Autor:
Tomochika Matsushita, Yoshinobu Igarashi, Hiroshi Yamada, Kayo Sumida, Tetsuro Urushidani, Naoki Toritsuka, Mikio Aoki, Kaori Abe-Tomizawa, Yasuo Ohno
Publikováno v:
Human & Experimental Toxicology. 30:1701-1709
Dimethyl sulfoxide (DMSO) is a very common organic solvent used for dissolving lipophilic substances, for example for in vitro cell-based assays. At the same time, DMSO is known to be cytotoxic at high concentrations. Therefore, it is important to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0a317c9a4e087e3663d702ed97494
https://doi.org/10.1177/0960327111399325
https://doi.org/10.1177/0960327111399325
Autor:
Yoko Hirabayashi, Tomochika Matsushita, Tohru Inoue, Ikuo Horii, Kazuko Kobayashi, Hiromi Suzuki, Tomoaki Inoue
Publikováno v:
Journal of Applied Toxicology. 28:227-236
The study examined the feasibility of screening for hepatotoxicity by an in vitro gene expression analysis using rat primary hepatocytes and Affymetrix Rat Toxicology U34 arrays. Hepatocytes were exposed for 6 or 24 h to eight drugs, with different m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7d770a4374877be3fa5dd9f594602e
https://doi.org/10.1002/jat.1328
https://doi.org/10.1002/jat.1328
Autor:
Shuji Hayashi, Miho Nagayasu, Shuichi Chiba, Tomochika Matsushita, Yuichiro Yamada, Kazuya Kimura, Chisako Kanamaru, Atsushi Suda
Publikováno v:
The Journal of toxicological sciences. 39(1)
Heat shock protein 90 (Hsp90) is a constitutively expressed molecular chaperone and plays an important role in the folding of client proteins with key regulatory roles in growth, survival, differentiation and metastasis. Because inhibition of Hsp90 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d854b9d64835d885a76b1594f26183
https://pubmed.ncbi.nlm.nih.gov/24418710
https://pubmed.ncbi.nlm.nih.gov/24418710
Autor:
Katsuhiko Minoura, Tetsuro Shingu, Tomochika Matsushita, Atsushi Numata, Chika Takahashi, Mitsunobu Doi, Yuko Kumeda
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2345-2353
Seven new fumiquinazolines (FQs) A–G have been isolated from a strain of Aspergillus fumigatus originally separated from the marine fish Pseudolabrus japonicus, and their stereostructures and conformations have been established on the basis of spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3762803f35a2e33bfb8aef9844564484
https://doi.org/10.1039/p19950002345
https://doi.org/10.1039/p19950002345
Autor:
Tomochika Matsushita, Chika Takahashi, Atsushi Numata, Tetsuro Shingu, Mitsunobu Doi, Katsuhiko Minoura, Yuko Kumeda
Publikováno v:
ChemInform. 27
Seven new fumiquinazolines (FQs) A–G have been isolated from a strain of Aspergillus fumigatus originally separated from the marine fish Pseudolabrus japonicus, and their stereostructures and conformations have been established on the basis of spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b23f1ffa7935b2d7381d1cd638c66f6
https://doi.org/10.1002/chin.199603272
https://doi.org/10.1002/chin.199603272