Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Tomoatsu Hayashi"'
Autor:
Ayako Kawabata, Tomoatsu Hayashi, Yoko Akasu-Nagayoshi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Aikou Okamoto, Tetsu Akiyama
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 4, Pp 1587-1596 (2022)
Epithelial ovarian cancer is classified into four major histological subtypes: serous, clear cell, endometrioid and mucinous. Ovarian clear cell carcinoma (OCCC) responds poorly to conventional chemotherapies and shows poor prognosis. Thus, there is
Externí odkaz:
https://doaj.org/article/da6dba27fdda494b9c8dfff75aa271d7
Autor:
Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Tetsu Akiyama
Publikováno v:
FEBS Open Bio, Vol 12, Iss 3, Pp 582-593 (2022)
Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies. In order to identify novel genes critical to OCCC growth, we carried out a co
Externí odkaz:
https://doaj.org/article/fee9bc37aa154de78549a667a47d55cf
Autor:
Ken Matsuura, Shizuka Kobayashi, Kohtarou Konno, Miwako Yamasaki, Takahiro Horiuchi, Takao Senda, Tomoatsu Hayashi, Kiyotoshi Satoh, Fumiko Arima-Yoshida, Kei Iwasaki, Lumi Negishi, Naomi Yasui-Shimizu, Kazuyoshi Kohu, Shigenori Kawahara, Yutaka Kirino, Tsutomu Nakamura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe, Tetsu Akiyama
Publikováno v:
J Neurosci
Signal-induced proliferation-associated 1 (SIPA1)-like 1 (SIPA1L1; also known as SPAR1) has been proposed to regulate synaptic functions that are important in maintaining normal neuronal activities, such as regulating spine growth and synaptic scalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89059b4b8bb5b8a4c264909839843927
https://doi.org/10.1523/jneurosci.0569-21.2022
https://doi.org/10.1523/jneurosci.0569-21.2022
Autor:
Yoko Akasu‐Nagayoshi, Tomoatsu Hayashi, Ayako Kawabata, Naomi Shimizu, Ai Yamada, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Aikou Okamoto, Tetsu Akiyama
Publikováno v:
Cancer science. 113(6)
Ovarian cancer is the fifth most common cause of cancer-related death in women. Ovarian clear cell carcinoma (OCCC) is a chemotherapy-resistant epithelial ovarian cancer with poor prognosis. As a basis for the development of therapeutic agents that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ad2cf957015b3e6a409bb7520b9735
https://pubmed.ncbi.nlm.nih.gov/35377528
https://pubmed.ncbi.nlm.nih.gov/35377528
Autor:
Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Tetsu Akiyama
Publikováno v:
FEBS open bio. 12(3)
Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies. In order to identify novel genes critical to OCCC growth, we carried out a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbc62d7c400162ceb454de4d3be4eea
https://pubmed.ncbi.nlm.nih.gov/34965029
https://pubmed.ncbi.nlm.nih.gov/34965029
Autor:
Naoki Goshima, Lumi Negishi, Kei Iwasaki, Yasuko Takeda, Tomoatsu Hayashi, Tetsu Akiyama, Yuki Kamoshida, Akiko Kurimoto, Kenzui Taniue, Yoshifumi Kawamura
Publikováno v:
Oncogene. 39:1018-1030
The epigenetic factor UHRF1 regulates transcription by modulating DNA methylation and histone modification, and plays critical roles in proliferation, development, and tumorigenesis. Here, we show that Wnt/c-Myc signaling upregulates UHRF1, which in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34052a40ba624d8bc258b30baaa7a27b
https://doi.org/10.1038/s41388-019-1032-y
https://doi.org/10.1038/s41388-019-1032-y
Autor:
Shigenori Kawahara, Kiyotoshi Satoh, Tomoatsu Hayashi, Yohei Kirino, Tadashi Yamamoto, Kohtarou Konno, Fumiko Arima-Yoshida, Kazuyoshi Kohu, Terumi Horiuchi, Negishi L, Kiyotaka Iwasaki, Masahiko Watanabe, Toshiya Manabe, Shizuka Kobayashi, Michimasa Yamasaki, Takao Senda, Matsuura K, Takahisa Nakamura, Yasui-Shimizu N, Tetsu Akiyama
SIPA1L1 (also known as SPAR1) has been proposed to regulate synaptic functions that are important in maintaining normal neuronal activities, such as regulating spine growth and synaptic scaling, as a component of the postsynaptic density (PSD)-95/N-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addfc32bd64b3c422055f708df64e8b2
https://doi.org/10.1101/2021.02.12.430872
https://doi.org/10.1101/2021.02.12.430872
Autor:
Tomoatsu Hayashi, Katsuhiko Shirahige, Ryuichiro Nakato, Tatsuya Akutsu, Tetsu Akiyama, Katsunori Fujiki, Natsu Nakajima
Publikováno v:
Nucleic Acids Research
Single-cell RNA-seq (scRNA-seq) can be used to characterize cellular heterogeneity in thousands of cells. The reconstruction of a gene network based on coexpression patterns is a fundamental task in scRNA-seq analyses, and the mutual exclusivity of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65996f6803f0aa33b5e2d1fbfd10283f
https://doi.org/10.1093/nar/gkab601
https://doi.org/10.1093/nar/gkab601
Autor:
Kanae Echizen, Yasushi Ino, Tetsu Akiyama, Yukiko Nasu-Nishimura, Yasuyuki Morishita, Viviane Tabar, Kosuke Funato, Naomi Shimizu, Lumi Negishi, Ryo Koyama-Nasu, Akitake Mukasa, Nobuhito Saito, Tomoki Todo, Tomoatsu Hayashi
Publikováno v:
EMBO reports. 19
Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis. Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB, and RTK pathways, are commonly deregulated in glioblastomas. However, the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7789e11f167ab00a2609a5abb7717d20
https://doi.org/10.15252/embr.201745587
https://doi.org/10.15252/embr.201745587
Autor:
Tomoatsu Hayashi, Kazuyuki Sugita, Tetsu Akiyama, Chikashi Toyoshima, Akio Kitao, Era Morishita, Nobuhiko Wakai, Yuichi Hashimoto, Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:328-339
Human sirtuin 2 (SIRT2) is an attractive target molecule for development of drugs to treat neurodegenerative diseases and cancer, because SIRT2 inhibitors have a protective effect against neurodegeneration and an anti-proliferative effect on cancer s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08316736a78d8ed4f8d008bc3d699a3
https://doi.org/10.1016/j.bmc.2014.11.027
https://doi.org/10.1016/j.bmc.2014.11.027