Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tomoaki Takakura"'
Autor:
Robert M, Hoffman, Yuying, Tan, Shukuan, Li, Qinghong, Han, Shigeo, Yagi, Tomoaki, Takakura, Akio, Takimoto, Kenji, Inagaki, Daizou, Kudou
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1866
The elevated requirement for methionine (MET) of cancer cells is termed MET dependence. To selectively target the MET dependence of tumors for treatment on a large-scale preclinical and clinical basis, the L-methionine α-deamino-γ-mercaptomethane-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9177cafb238da08b8c0290993cd8fe72
https://pubmed.ncbi.nlm.nih.gov/30725412
https://pubmed.ncbi.nlm.nih.gov/30725412
Autor:
Shigeo Yagi, Kenji Inagaki, Qinghong Han, Akio Takimoto, Tomoaki Takakura, Shukuan Li, Robert M. Hoffman, Daizou Kudou, Yuying Tan
Publikováno v:
Methods in Molecular Biology ISBN: 9781493987955
The elevated requirement for methionine (MET) of cancer cells is termed MET dependence. To selectively target the MET dependence of tumors for treatment on a large-scale preclinical and clinical basis, the L-methionine α-deamino-γ-mercaptomethane-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dac90ed918279972c9ba7d4a9061b45
https://doi.org/10.1007/978-1-4939-8796-2_10
https://doi.org/10.1007/978-1-4939-8796-2_10
Autor:
Nobuyoshi Esaki, Takashi Itakura, Robert M. Hoffman, Shigeo Yagi, Takaomi Ito, Akio Takimoto, Takumi Nakamura, Yoshihide Notsu, Tomoaki Takakura, Kenji Inagaki
Publikováno v:
Applied Microbiology and Biotechnology. 70:183-192
L-Methionine gamma-lyase is a pyridoxal 5'-phosphate-dependent enzyme which has tumor selective anticancer activity. An efficient production process for the recombinant enzyme was constructed by using the overexpression plasmid in Escherichia coli, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa716e326c9e35061c07dbd6a2a76600
https://doi.org/10.1007/s00253-005-0038-2
https://doi.org/10.1007/s00253-005-0038-2
Autor:
Takaomi Ito, Shigeo Yagi, Masahiro Ohno, Hiroshi Yoshida, Tomoaki Takakura, Kenji Inagaki, Yoshihide Notsu, Akio Takimoto, Hirofumi Nagatome, Nobuyoshi Esaki, Yoshinao Kobayashi, Takayuki Yoshioka, Robert M. Hoffman
Publikováno v:
Cancer Research. 66:2807-2814
A highly potent recombinant l-methionine γ-lyase (METase) conjugated with polyethylene glycol (PEG) was characterized physicochemically and pharmacokinetically in vivo and in vitro. Pegylated METase (PEG-METase), which contains pyridoxal 5′-phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332979e1c0fa20b07fd649a48a8ee30
https://doi.org/10.1158/0008-5472.can-05-3910
https://doi.org/10.1158/0008-5472.can-05-3910
Autor:
Akio Takimoto, Junhua Wang, Eugene P. Frenkel, Jinbao Xu, Takayuji Yoshioka, Yuying Tan, Dongdong Zhang, Robert M. Hoffman, Xinghua Sun, Quan Lu, Shigeo Yagi, Shukuan Li, Zhijian Yang, Tomoaki Takakura, Yoshinao Kobayashi, Changgen Lian, Ying Zhang, Chunmei Chen
Publikováno v:
Cancer Research. 64:6673-6678
Methionine depletion by recombinant methioninase (rMETase) has been demonstrated previously to be highly effective in tumor-bearing mouse models. However, the therapeutic potential of rMETase has been limited by its short plasma half-life and immunol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b636d5c2212395ac5184d344f56be39c
https://doi.org/10.1158/0008-5472.can-04-1822
https://doi.org/10.1158/0008-5472.can-04-1822
Autor:
Yoshinao Kobayashi, Xiaoen Wang, Robert M. Hoffman, Xinghua Sun, Yuying Tan, Shigeo Yagi, Zhijian Yang, Shukuan Li, Takayuki Yoshioka, Tomoaki Takakura, Nan Zhang, Akinori Suginaka, Akio Takimoto, Eugene P. Frenkel
Publikováno v:
Cancer Research. 64:5775-5778
Recombinant methioninase (rMETase) has been shown to target the elevated methionine (MET) dependence of tumor cells and arrest their growth as well as make tumors more sensitive to standard chemotherapy agents. Polyethylene glycol (PEG)-modified rMET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1956620cd72e904e1577c5e14b20ed
https://doi.org/10.1158/0008-5472.can-04-1406
https://doi.org/10.1158/0008-5472.can-04-1406
Autor:
Kenji Mitsushima, Hidehiko Tanaka, Kenji Inagaki, Kenji Soda, Akio Takimoto, Nobuyoshi Esaki, Shigeo Yagi, Tomoaki Takakura
Publikováno v:
Analytical Biochemistry. 327:233-240
L-Methionine gamma-lyase (EC 4.4.1.11) is a pyridoxal 5'-phosphate-dependent multifunctional enzyme. Measuring the initial velocity of alpha-ketobutyrate production by alpha,gamma-elimination of L-methionine catalyzed by L-methionine gamma-lyase is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c362886579ba7e161195e7b98d05ec
https://doi.org/10.1016/j.ab.2004.01.024
https://doi.org/10.1016/j.ab.2004.01.024
Autor:
Mitsunobu Matsumoto, Takashi Takahashi, Hideki Ohta, Takahiro Heishi, Chihiro Yamauchi, Kanji Hojo, Shingo Arioka, Takumi Nakamura, Hiroki Miyashita, Hikaru Sonoda, Yuichi Mitsuda, Yuichi Oike, Yasufumi Sato, Yasuhiro Suzuki, Tomoaki Takakura, Tomoko Hosaka
Publikováno v:
The American journal of pathology. 176(4)
During cancer progression, the angiogenesis that occurs is involved in tumor growth and hematogenous-distant metastasis, whereas lymphangiogenesis is involved in regional lymph node metastasis. Angiogenesis is counterregulated by various endogenous i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a926f0081433948165854cd4a66d45
https://pubmed.ncbi.nlm.nih.gov/20133819
https://pubmed.ncbi.nlm.nih.gov/20133819
Autor:
Takaomi Ito, Akio Takimoto, Tomoaki Takakura, Hiroko Togame, Masataka Fumoto, Takanori Iwasaki, Taichi Ueda, Hirosato Kondo, Keiko Kawamoto, Hirofumi Nagatome, Shin ichi Mihara, Takeo Oshima, Kohji Hanasaki, Shin-Ichiro Nishimura, Kenji Asakura, Kazuyoshi Tomita, Yoshihide Notsu
Publikováno v:
Journal of the American Chemical Society. 131(17)
Glucagon-like peptide 1 (7-36) amide (GLP-1) has been attracting considerable attention as a therapeutic agent for the treatment of type 2 diabetes. In this study, we applied a glycoengineering strategy to GLP-1 to improve its proteolytic stability a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc33d39fae3d1e0c2c06136844ab056
https://pubmed.ncbi.nlm.nih.gov/19361194
https://pubmed.ncbi.nlm.nih.gov/19361194
Autor:
Masao Yamashita, Daizou Kudou, Akio Takimoto, Takashi Tamura, Shigeo Yagi, Takayuki Yoshioka, Tomoaki Takakura, Nobuyoshi Esaki, Robert M. Hoffman, Shintaro Misaki, Kenji Inagaki
Publikováno v:
Journal of biochemistry. 141(4)
l-Methionine gamma-lyase (EC 4.4.1.11, MGL_Pp) from Pseudomonas putida is a multifunctional enzyme, which belongs to the gamma-family of pyridoxal-5'-phosphate (PLP) dependent enzymes. In this report, we demonstrate that the three-dimensional structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a896a70648756d73a9ec28c8c154ec1e
https://pubmed.ncbi.nlm.nih.gov/17289792
https://pubmed.ncbi.nlm.nih.gov/17289792