Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tomoaki Shinkawa"'
Autor:
Tomoaki Shinkawa, Yoshio Yoshioka
Publikováno v:
IEEJ Transactions on Fundamentals and Materials. 122:824-831
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bc4c74d82084e7663ee1db95f0bdd75
https://doi.org/10.1541/ieejfms.122.824
https://doi.org/10.1541/ieejfms.122.824
Publikováno v:
IEEJ Transactions on Fundamentals and Materials. 122:832-839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befcf29cc8cba83bab73a6d288939e3a
https://doi.org/10.1541/ieejfms.122.832
https://doi.org/10.1541/ieejfms.122.832
Autor:
Yoshio Yoshioka, Tomoaki Shinkawa
Publikováno v:
IEEJ Transactions on Fundamentals and Materials. 120:250-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1512d189fb79c6ef94509f5982a7a632
https://doi.org/10.1541/ieejfms1990.120.2_250
https://doi.org/10.1541/ieejfms1990.120.2_250
Synthesis and diuretic activity of 2,3-dihydro-4(1H)-quinolinone 4-oxime-O-sulfonic acid derivatives
Autor:
Kikuo Ohtomo, Hidemitsu Nishida, Masahiro Mizota, Yoshiaki Yamashita, Kazuo Kato, Kazumi Nishijima, Naofumi Sato, Tomoaki Shinkawa, Sotaro Miyano, Yoshiaki Onuki
Publikováno v:
European Journal of Medicinal Chemistry. 33:267-277
The diuretic activity of 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime 1 (M12285) was previously shown to derive from a 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime-O-sulfonic acid salt as a rat metabolite. Thus, in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df6f9d5c6927c3be353d893f254f9715
https://doi.org/10.1016/s0223-5234(98)80061-5
https://doi.org/10.1016/s0223-5234(98)80061-5
Publikováno v:
Nephron. 76:300-306
The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::232610d4c21bfb2102c6f5ebd649983b
https://doi.org/10.1159/000190195
https://doi.org/10.1159/000190195
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 433:9-15
We investigated the uptake of human urinary trypsin inhibitor (UTI) by the kidney epithelial cells, LLC-PK1. Indirect immunogold techniques with an electron microscope demonstrated the localization of UTI within the cells after an incubation during w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf047f9223edc3b17b9842a4696e07e
https://doi.org/10.1007/s004240050242
https://doi.org/10.1007/s004240050242
Autor:
Masanori Nakakuki, Tomoaki Shinkawa, Masaaki Ishibashi, Mitsutoshi Watanabe, Masahiro Mizota, Fumiaki Yamasaki
Publikováno v:
Nephron. 74:158-167
The development of azotemia after cisplatin injection in mice was inhibited by ulinastatin treatment in a dose-dependent manner. Reduction in creatinine clearance and elevation in fractional excretion of sodium in mice receiving cisplatin was amelior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08f3731406aa15508301d5074a8ba37
https://doi.org/10.1159/000189296
https://doi.org/10.1159/000189296
Autor:
Tomoaki Shinkawa, Fumiaki Yamasaki, Masanori Nakakuki, Kazumi Nishijima, Tatsuto Notsu, Masashi Imai, Koji Yoshitomi
Publikováno v:
European Journal of Pharmacology. 238:317-325
We investigated the mechanism of action of a novel ‘high ceiling’ diuretic, M17055, in in vivo clearance studies with anesthetized dogs during water diuresis and in vitro microperfusion studies of isolated rabbit renal tubules. In the clearance s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb0c33aab1645054d518c0e0ff03e0b
https://doi.org/10.1016/0014-2999(93)90863-d
https://doi.org/10.1016/0014-2999(93)90863-d
Autor:
Akio Uemura, Yutaka Kato, Naoko Tsuchiya, Masahiro Mizota, Tomoaki Shinkawa, Fumiaki Yamasaki
Publikováno v:
Japanese Journal of Pharmacology. 63:241-249
We investigated the effects of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats (SHR). M17055 was orally administered once a day for 24 consecutive days to 14-week-old male SHR. M17055 at d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa8d9e23fb5d3c7795c5f277decb03a
https://doi.org/10.1254/jjp.63.241
https://doi.org/10.1254/jjp.63.241
Autor:
Tomoaki Shinkawa, Naofumi Sato, Yoshiaki Yamashita, Yoshiaki Onuki, Hidemitsu Nishida, Sotaro Miyano, Masahiro Mizota, Kazuo Kato, Kikuo Ohtomo, Kazumi Nishijima
Publikováno v:
ChemInform. 29
The diuretic activity of 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime 1 (M12285) was previously shown to derive from a 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime-O-sulfonic acid salt as a rat metabolite. Thus, in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::919cc932c359749537da38940033bda6
https://doi.org/10.1002/chin.199837164
https://doi.org/10.1002/chin.199837164