Výsledky vyhledávání - "Tomoaki Osugi"

Akademický článek

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells.

Autor: Sharon L Paige, Tomoaki Osugi, Olga K Afanasiev, Lil Pabon, Hans Reinecke, Charles E Murry

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11134 (2010)

Wnt/beta-catenin signaling is an important regulator of differentiation and morphogenesis that can also control stem cell fates. Our group has developed an efficient protocol to generate cardiomyocytes from human embryonic stem (ES) cells via inducti

Externí odkaz: https://doaj.org/article/e536470824d54784afade1576f5ad104

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1386-P: Confirmation of the Criteria for Insulin Administration at the Start of Steroid Therapy

Autor: SHIZUKA KANEKO, KAZUYA MOTOHASHI, TOMOKO MINAMI, YOKO UEBA, TOMOAKI OSUGI, SHINSUKE TOKUMOTO

Publikováno v: Diabetes. 71

Blood glucose elevates at initial high-dose steroid (HDS) administration and is prolonged by persistent amplification of glucagon-induced glycogenesis. Insulin (INS) administration at initial dose of HDS will avoid this. However, INS administration c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e00fbe84109b7f77d73d41c0900adf
https://doi.org/10.2337/db22-1386-p

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Restless legs syndrome in patients with type 2 diabetes: effectiveness of pramipexole therapy

Autor: Hiroshi Takayama, Yanyan Liu, Tomoaki Osugi, Shin-ichi Harashima, Nobuya Inagaki, Yu Wang, Akiko Nishimura

Publikováno v: BMJ Supportive & Palliative Care. 6:89-93

We investigated the prevalence of restless legs syndrome (RLS) in Japanese patients with type 2 diabetes and assessed the efficacy of pramipexole therapy.One hundred patients with type 2 diabetes without secondary causes of RLS were sequentially scre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a37b5184ea66780cdb6e0f2b76598f
https://doi.org/10.1136/bmjspcare-2014-000691

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Overexpression of Polycomb-Group Gene rae28 in Cardiomyocytes Does Not Complement Abnormal Cardiac Morphogenesis in Mice Lacking rae28 But Causes Dilated Cardiomyopathy

Autor: Hideyuki Koga, Keiko Yamauchi-Takihara, Daihachiro Tomotsune, Yoshihiro Takihara, Manabu Shirai, Yoshikazu Kaji, Junichi Hara, Kiyomasa Nishii, Takeshi Miwa, Akihisa Sawada, Yosaburo Shibata, Ji Yoo Kim, Tomoaki Osugi

Publikováno v: Laboratory Investigation. 82:375-385

The Polycomb-group genes (PcG) are widely conserved from Drosophila to mammals and are required for maintaining positional information during development. The rae28 gene (rae28) is a member of the mouse PcG. Mice deficient in rae28 (rae28(-/-)) demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce40bc6bca4659068f643a292fc2dc2d
https://doi.org/10.1038/labinvest.3780432

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Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway

Autor: Yoshikazu Nakaoka, Masahiro Izumi, Tomoaki Osugi, Keiko Yamauchi-Takihara, Keita Kunisada, Tadamitsu Kishimoto, Masanobu Funamoto, Shinji Negoro, Yuichi Oshima, Hisao Hirota, Yasushi Fujio, Eiro Tone

Publikováno v: Journal of Biological Chemistry. 276:31133-31141

Bone morphogenetic protein (BMP)-2 has been shown to induce ectopic expression of cardiac transcription factors and beating cardiomyocytes in non-precardiac mesodermal cells, suggesting that BMP-2 is an inductive signaling molecule that participates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8a0470c25ff6eff1e30ed8306c64c2
https://doi.org/10.1074/jbc.m101463200

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Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes

Autor: Kazuyuki Yoshizaki, Masahiro Izumi, Eiroh Tone, Masanobu Funamoto, Tomoaki Osugi, Keiko Yamauchi-Takihara, Tadamitsu Kishimoto, Kenneth Walsh, Keita Kunisada, Hisao Hirota, Shinji Negoro, Yasushi Fujio

Publikováno v: Journal of Biological Chemistry. 275:10561-10566

Activation of glycoprotein (gp) 130 transduces hypertrophic and cytoprotective signals in cardiac myocytes. In the present study, we have demonstrated that signals through gp130 increase the expression of vascular endothelial growth factor (VEGF) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4defecdda6ea0f95ae441f03e1d047
https://doi.org/10.1074/jbc.275.14.10561

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A1C but Not Serum Glycated Albumin Is Elevated Because of Iron Deficiency in Late Pregnancy in Diabetic Women

Autor: Sanai Noguchi, Masafumi Koga, Tomoaki Osugi, Yasuhiko Morimoto, Rieko Toyoda, Kunihiko Hashimoto, Shiro Imai, Masako Waguri, Tomio Fujita, Soji Kasayama, Kenshi Wasada

Publikováno v: Diabetes Care

OBJECTIVE We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon is observed in pregnant women with diabetes. RESEARCH DESIGN AND M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed4881b56218e68ddb2ddf5ba89694a
https://doi.org/10.2337/dc09-1954

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Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Autor: Keiko Yamauchi-Takihara, Tadamitsu Kishimoto, Masahiro Izumi, Keita Kunisada, Martine I. Darville, Shinji Negoro, Yoshikazu Nakaoka, Yuichi Oshima, Decio L. Eizirik, Tomoaki Osugi, Hisao Hirota, Masanobu Funamoto, Yasushi Fujio

Publikováno v: Circulation. 104:979-981

Background Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3 signal may be involved in the detoxification of reactive oxygen species (ROS). M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7a233c63253f24b7ca3cb50bbbb798
https://doi.org/10.1161/hc3401.095947

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Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

Autor: Shuichi Ueno, Randall T. Moon, Lil Pabon, Gilbert Weidinger, Hans Reinecke, Aimee D. Kohn, Jonathan L. Golob, Charles E. Murry, Tomoaki Osugi

Understanding pathways controlling cardiac development may offer insights that are useful for stem cell-based cardiac repair. Developmental studies indicate that the Wnt/beta-catenin pathway negatively regulates cardiac differentiation, whereas studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc58f511afb7643bcfe1d7a4101b11d4
https://europepmc.org/articles/PMC1876428/

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The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis

Autor: Manabu Shirai, Tomoaki Osugi, Hideyuki Koga, Yoshikazu Kaji, Eiki Takimoto, Issei Komuro, Junichi Hara, Takeshi Miwa, Keiko Yamauchi-Takihara, Yoshihiro Takihara

The Polycomb-group (PcG) gene Rae28 is a mammalian homologue of the Drosophila gene polyhomeotic. PcG genes are known to maintain transcription states, once initiated, probably by regulating chromatin structure. Since homozygous Rae28-deficient (Rae2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d012ff916b03b989e7ef1eb10ae7bc
https://europepmc.org/articles/PMC151044/

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