Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tomoaki Komai"'
Autor:
Anri Aki, Kento Tanaka, Nobumi Nagaoka, Takako Kimura, Daichi Baba, Yoshikuni Onodera, Teiji Wada, Hiroaki Maeda, Toshiyuki Nakanishi, Toshinori Agatsuma, Tomoaki Komai
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 8, Pp 478-488 (2020)
Abstract ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes. It is known that ORAI1 is essential for the activation of T cel
Externí odkaz:
https://doaj.org/article/052ac0ac4d254d4e9eaa0cf0d935e02f
Autor:
Tomoaki Komai, Toshiyuki Nakanishi, Daichi Baba, Hiroaki Maeda, Anri Aki, Teiji Wada, Takako Kimura, Yoshikuni Onodera, Nagaoka Nobumi, Toshinori Agatsuma, Tanaka Kento
Publikováno v:
FASEB BioAdvances
FASEB BioAdvances, Vol 2, Iss 8, Pp 478-488 (2020)
FASEB BioAdvances, Vol 2, Iss 8, Pp 478-488 (2020)
ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes. It is known that ORAI1 is essential for the activation of T cells and ma
Autor:
Miyuki Nagasaki, Tomoaki Komai, Tomiichiro Oda, Ikue Iino, Hiroaki Maeda, Sachiko Takaishi, Masakatsu Suzuki, Yoshiko Onozawa
Publikováno v:
Journal of Biological Chemistry. 288:10684-10691
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids (MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that GPR84 was activated by MCFAs with the hydroxyl group at the 2- or 3-posi
Publikováno v:
European Journal of Pharmacology. 654:315-319
T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor identified by differential mRNA display during thymocyte apoptosis induced by T cell receptor engagement. To examine the physiological role of an orphan G-protein-coupled receptor
Autor:
Shuichi Miyamoto, Takashi Nishigaki, Ryuichi Yagi, Hiroshi Handa, Yasuko Ishikawa, Tomoaki Komai, Atsushi Kasuya, Hisayo Suzuki-Sunagawa
Publikováno v:
Biochemical and Biophysical Research Communications. 230:557-561
In cell-free proteolytic processing using recombinant HIV-1 protease and Gag precursor polypeptide, certain simple oxim derivatives containing halogenomethylketone and phenyl moieties displayed HIV-1 protease inhibitory activity. Their Ki values rang
Autor:
Takashi Nishigaki, Ryuichi Yagi, Hiroshi Mohri, Hiroshi Handa, Hisayo Suzuki-Sunagawa, Mitsuya Sakurai, Kaoru Shimada, Higashida Susumu, Shinichi Oka, Tomoaki Komai, Akira Yasuoka, Satoshi Kimura, Yuichiro Yabe, Machiko Sugano
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:175-180
In a series of compounds containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found
Autor:
Tomoaki Komai, Yoshifumi Fujita, Tomiichiro Oda, Harumi Kuwabara, Yoshiko Onozawa, Miyuki Nagasaki
Publikováno v:
European journal of pharmacology. 683(1-3)
An orphan G-protein-coupled receptor, T cell death-associated gene 8 (TDAG8) which has been reported to be a proton sensor, inhibits the production of pro-inflammatory cytokines induced by extracellular acidification. Recently, we have found that TDA
Autor:
Tetsushi Katsube, Hiroto Kashiwase, Kaoru Shimada, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Takashi Nishigaki, Kenji Momota, Toshinori Ohmine, Satoshi Kimura
Publikováno v:
ChemInform. 31
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the comp
Autor:
Akiko Yonemura, Masahiko Ohtsuki, Tomoaki Komai, Yoshiko Onozawa, Takashi Yamoto, Yasushi Yoshigae, Kimihisa Ichikawa, Junichi Nakayama, Yukie Ogawa, Toru Tatsuta, Motoko Saito
Publikováno v:
International immunology. 18(1)
Fas-mediated apoptosis plays an important role in the immune system, including the elimination of autoreactive lymphoid cells. The Fas-mediated signaling pathway is classified into two types, type I and type II, in human lymphoid cell lines. We inves
Publikováno v:
Experimental cell research. 291(1)
Viruses have evolved different strategies to interfere with apoptotic pathways in order to halt cellular responses to infection. The herpes simplex virus 1 (HSV-1) Us3 open-reading frame encodes a serine/threonine protein kinase that participates in