Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomoaki Kimoto"'
Autor:
Naoko Ohshita, Anna Tajima, Taishi Higashi, Keiichi Motoyama, Sawako Koyama, Ruriko Iibuchi, Shiuhei Mieda, Kenji Handa, Tomoaki Kimoto, Hidetoshi Arima
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 221-222 (2016)
Externí odkaz:
https://doaj.org/article/c8399d2938e248a3b57ab40a7ea776e7
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2457-2463
The stabilization of antibodies in aqueous solution against physical stress remains a problematic issue for pharmaceutical applications. Recently, protein-polyelectrolyte complex (PPC) formation using poly(amino acids) was proposed to prepare antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8144acfa6c1018867fcfb6b89f10e
https://doi.org/10.1002/jps.24515
https://doi.org/10.1002/jps.24515
Autor:
Izaki Shunsuke, Tomoaki Kimoto, Takaaki Kurinomaru, Takuya Maruyama, Takayuki Uchida, Kentaro Shiraki, Kenji Handa
Publikováno v:
Journal of pharmaceutical sciences. 104(6):1929-1937
Development of high-concentration antibody formulations for subcutaneous administration remains challenging. Recently, a precipitation-redissolution method was proposed to prepare suspensions or precipitates of salt-dissociable protein-poly(amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c641e03cdf72e44fd1d5550a1b20c20f
https://tsukuba.repo.nii.ac.jp/records/34571
https://tsukuba.repo.nii.ac.jp/records/34571
Autor:
Tomoaki Kimoto, Kenji Handa, Takuya Maruyama, Izaki Shunsuke, Kentaro Shiraki, Takaaki Kurinomaru
Publikováno v:
Journal of Pharmaceutical Sciences. 103:2248-2254
A method for concentration of protein solutions is required for high-dosage protein formulation. Here, we present a precipitation–redissolution method by poly(amino acid) for proteins, including therapeutic enzymes, antibodies, and hormones. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f609d55408a93f540205c9486ab27cf
https://doi.org/10.1002/jps.24025
https://doi.org/10.1002/jps.24025
Autor:
Shiuhei Mieda, Tomoaki Kimoto, Taishi Higashi, Ruriko Iibuchi, Naoko Ohshita, Yoshihito Yamashita, Keiichi Motoyama, Sawako Koyama, Tatsunori Hirotsu, Takayuki Uchida, Hidetoshi Arima, Kenji Handa
Publikováno v:
Journal of pharmaceutical sciences. 106(5)
Antibodies often have poor physicochemical stability during storage and transport, which is a serious drawback for the development of antibody-based drugs. In this study, we prepared polypseudorotaxane (PPRX) hydrogels consisting of cyclodextrins (Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aa5379803c09932d9f1484ebc7462a
https://pubmed.ncbi.nlm.nih.gov/28089687
https://pubmed.ncbi.nlm.nih.gov/28089687
Autor:
Shiuhei Mieda, Irhan Ibrahim Abu Hashim, Keiichi Motoyama, Taishi Higashi, Kenji Handa, Naoko Ohshita, Hidetoshi Arima, Anna Tajima, Ruriko Iibuchi, Tatsunori Hirotsu, Sawako Koyama, Tomoaki Kimoto
To achieve the potent therapeutic effects of human immunoglobulin G (IgG), highly concentrated formulations are required. However, the stabilization for highly concentrated human IgG is laborious work. In the present study, to investigate the potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25aacd840e653be3a7cbffd755cdb6f
https://europepmc.org/articles/PMC4666269/
https://europepmc.org/articles/PMC4666269/
Autor:
Takuya Maruyama, Takaaki Kurinomaru, Kenji Handa, Izaki Shunsuke, Kentaro Shiraki, Tomoaki Kimoto
Publikováno v:
Journal of bioscience and bioengineering. 120(6)
Long-term storage in aqueous solution has been demanded for the practical application of therapeutic proteins. Recently, a precipitation-redissolution method was proposed to prepare salt-dissociable protein-polyelectrolyte complex (PPC). To elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907f0f358427df34f79d126790cb1e71
https://pubmed.ncbi.nlm.nih.gov/25979123
https://pubmed.ncbi.nlm.nih.gov/25979123
Autor:
Anna Tajima, Shiuhei Mieda, Sawako Koyama, Ruriko Iibuchi, Tomoaki Kimoto, Keiichi Motoyama, Taishi Higashi, Kenji Handa, Hidetoshi Arima, Naoko Ohshita
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 221-222 (2016)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e6cc1eabce775445697f1ad56101d2
http://www.sciencedirect.com/science/article/pii/S1818087615001890
http://www.sciencedirect.com/science/article/pii/S1818087615001890