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Akademický článek

Terminal bridging of siRNA duplex at the ribose 2′ position controls strand bias and target sequence preference

Autor: Atsushi Shibata, Hisao Shirohzu, Yusuke Iwakami, Tomoaki Abe, Chisato Emura, Eriko Aoki, Tadaaki Ohgi

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 468-477 (2023)

Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed. We generated a novel class of RNAi reagen

Externí odkaz: https://doaj.org/article/7fa797aaa0604488b979cd3b9dfb4ed7

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Akademický článek

Immaturin-Nuclease as a Model System for a Gene-Programmed Sexual Development and Rejuvenescence in Paramecium Life History

Autor: Nobuyuki Haga, Toshinori Usui, Yasuhiro Takenaka, Yuta Chiba, Tomoaki Abe

Publikováno v: Microorganisms, Vol 11, Iss 1, p 82 (2022)

Fertilization-initiated development and adult-onset aging are standard features in the life history of eukaryotes. In Paramecium, the number of cell divisions after the birth of a new generation is an essential parameter of sexual phase transition an

Externí odkaz: https://doaj.org/article/75415bdad47d495d8bceb3f5dfe48230

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Experimental Induction of Heterotrophic to Autotrophic Conversion, Realized by the Enforced Primary Endosymbiosis of Photosynthetic Bacteria onto Eukaryotic Amoebae

Autor: Yasuo Maeda, Tomoaki Abe

Publikováno v: Natural Science. 14:364-385

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::954b69fc3351d5033fc6016db52f49bd
https://doi.org/10.4236/ns.2022.149033

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Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity

Autor: Tomoyoshi, Imaizumi, Michinori, Akaiwa, Tomoaki, Abe, Takahiro, Nigawara, Takanori, Koike, Yoshiki, Satake, Kazushi, Watanabe, Osamu, Kaneko, Yasushi, Amano, Kenichi, Mori, Yosuke, Yamanaka, Takeyuki, Nagashima, Masashi, Shimazaki, Kazuyuki, Kuramoto

Publikováno v: Bioorganic & Medicinal Chemistry. 71:116949

RAS protein plays a key role in cellular proliferation and differentiation. RAS gene mutation is a known driver of oncogenic alternation in human cancer. RAS inhibition is an effective therapeutic treatment for solid tumors, but RAS protein has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d7da162113fdb0136dd48b51690460
https://doi.org/10.1016/j.bmc.2022.116949

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Azoreductase from alkaliphilic Bacillus sp. AO1 catalyzes indigo reduction

Autor: Toshihisa Ohshima, Hirokazu Suzuki, Tomoaki Abe, Katsumi Doi

Publikováno v: Applied Microbiology and Biotechnology. 102:9171-9181

Indigo is an insoluble blue dye historically used for dyeing textiles. A traditional approach for indigo dyeing involves microbial reduction of polygonum indigo to solubilize it under alkaline conditions; however, the mechanism by which microorganism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f377c270212d9bbc8dd7cb35d5e221
https://doi.org/10.1007/s00253-018-9284-y

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Influence of Spacer Length between Actuator and Sensor on Their Mutual Communications in Poly(N‑Isopropylacrylamide-co-β-Cyclodextrin), an Autonomous Coordinative Shrinking/Swelling Polymer

Autor: Takeo Yamaguchi, Tomoaki Abe, Takanori Tamaki, Hidenori Ohashi

Publikováno v: Macromolecules. 45(24):9742-9750

In living bodies, specific molecular recognition triggers various kinds of autonomous behaviors. To artificially reconstruct one such distinct phenomenon, an autonomous shrinking and subsequent reswelling of poly(N-isopropylacrylamide) (pNIPAM) havin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ffa23eafd09c5ca51013a2e2681328
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100647485

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Osmotic sensitive characteristics of an LmpB mutant strain in cellular slime mould Dictyostelium discoideum

Autor: Tomoaki Abe, Maki Sukegawa

Publikováno v: PLANT MORPHOLOGY. 22:73-77

As one of the cellular slime mould mutants produced with restriction enzymes mediated integration (REMI), we isolated a strain that carries an insertion mutation in LmpB gene. LmpB is a lysosomal protein and suggested to be involved in the endosome m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::737a53de557fb2479052e23600780692
https://doi.org/10.5685/plmorphol.22.73

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Tensile Strength of Superfine Grained Iron Produced by MM-SPS Method

Autor: Hisashi Kuwano, Tomoaki Abe, Satoshi Kawamura

Publikováno v: Journal of the Japan Society of Powder and Powder Metallurgy. 55:509-514

A consolidation process of the nanocrystalline iron powder has been investigated to produce a high strength bulk plate of superfine grained (SFG) pure iron. The nanocrystalline iron powder was prepared by mechanical milling (MM) of a high purity carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::feff84e25306bfffb72f5a629cda2b47
https://doi.org/10.2497/jjspm.55.509

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