Zobrazeno 1 - 10
of 500
pro vyhledávání: '"Tomoaki, Tanaka"'
Autor:
Rafaela Muniz de Queiroz, Gizem Efe, Asja Guzman, Naoko Hashimoto, Yusuke Kawashima, Tomoaki Tanaka, Anil K. Rustgi, Carol Prives
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Although the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that do not involve p53. As one example, it is
Externí odkaz:
https://doaj.org/article/6c7075f8b8934d2fa532d7c44cb97399
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110656- (2024)
Summary: Diabetes mellitus is induced by quantitative and qualitative decline in pancreatic β cells. Although its radical therapy has not yet been established, β cell regeneration is a promising option. We investigate here two mouse models of β ce
Externí odkaz:
https://doaj.org/article/7c38aa3bc583471abb24767acbe8419f
Autor:
Satomi Kono, Hidekazu Nagano, Yuki Taki, Takashi Kono, Naoko Hashimoto, Yasuhiro Nakamura, Naoko Inoshita, Masayuki Ohtsuka, Tomoaki Tanaka
Publikováno v:
Endocrine and Metabolic Science, Vol 15, Iss , Pp 100176- (2024)
Objective: Pancreatic neuroendocrine neoplasms (pNENs) are histologically classified as well-differentiated, poorly-differentiated, or mixed neuroendocrine-non-neuroendocrine neoplasms. There are unresectable pNENs owing to metastases or invasion in
Externí odkaz:
https://doaj.org/article/eccbf9f08c07454b8e8a04373892b580
Autor:
Ryo Hatano, Eunyoung Lee, Hiromi Sato, Masahiro Kiuchi, Kiyoshi Hirahara, Yoshimi Nakagawa, Hitoshi Shimano, Toshinori Nakayama, Tomoaki Tanaka, Takashi Miki
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101934- (2024)
Objectives: During fasting, liver pivotally regulates blood glucose levels through glycogenolysis and gluconeogenesis. Kidney also produces glucose through gluconeogenesis. Gluconeogenic genes are transactivated by fasting, but their expression patte
Externí odkaz:
https://doaj.org/article/78a6b078bf5845b5b374953ed9fb65fe
Autor:
Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Masanori Fujimoto, Akitoshi Nakayama, Takahiro Fuchigami, Yuki Taki, Tatsuma Matsuda, Hiroyuki Akamine, Satomi Kono, Takashi Kono, Masataka Yokoyama, Motoi Nishimura, Koutaro Yokote, Tatsuki Ogasawara, Yoichi Fujii, Seishi Ogawa, Eunyoung Lee, Takashi Miki, Tomoaki Tanaka
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic acidosis. Due to the rarity of FBPase deficiency, the mechanism by which the mutations cause
Externí odkaz:
https://doaj.org/article/ec6b457d1727479d8857f01897a31d6d
Autor:
Hanna Deguchi-Horiuchi, Sawako Suzuki, Eun Young Lee, Takashi Miki, Noriko Yamanaka, Ichiro Manabe, Tomoaki Tanaka, Koutaro Yokote
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Glutaminase 2 (GLS2), a master regulator of glutaminolysis that is induced by p53 and converts glutamine to glutamate, is abundant in the liver but also exists in pancreatic β-cells. However, the roles of GLS2 in islets associated with gluc
Externí odkaz:
https://doaj.org/article/121466c8480746d1bafc7987c16f68af
Autor:
Motoi Nishimura, Tomoaki Tanaka, Syota Murata, Akiko Miyabe, Takayuki Ishige, Kenji Kawasaki, Masataka Yokoyama, Naoko Hashimoto, Kazuyuki Yamagata, Hidekazu Nagano, Satomi Tojo-Nishimura, Kazuyuki Matsushita
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Although polymerase chain reaction (PCR) amplification and sequencing of the bacterial 16S rDNA region has numerous scientific applications, it does not provide DNA methylation information. Herein, we propose a simple extension for bisulfite
Externí odkaz:
https://doaj.org/article/36ae9e8117b1482886b1a75040eebc5b
Autor:
Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko Inoshita, Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Tomoaki Tanaka
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The genetic alterations, protein expressions, and clinical characteristics of growth hormone-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors are integrated to detect molecules associated with acromegaly characteristics.
Externí odkaz:
https://doaj.org/article/5fc1116226f2482f9b2e784b7ba13503
Autor:
Alimasi Aersilan, Naoko Hashimoto, Kazuyuki Yamagata, Masataka Yokoyama, Akitoshi Nakayama, Xiaoyan Shi, Hidekazu Nagano, Ikki Sakuma, Nijiro Nohata, Takashi Kinoshita, Naohiko Seki, Bahityar Rahmutulla, Atsushi Kaneda, Siti Nurul Zhahara, Yingbo Gong, Motoi Nishimura, Shoichiro Kawauchi, Eiryo Kawakami, Tomoaki Tanaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer. However, the relationship between the me
Externí odkaz:
https://doaj.org/article/1d5cdb93b0c54fa58e9cd7d3f4a488f0
Autor:
Masanori Fujimoto, Masataka Yokoyama, Masahiro Kiuchi, Hiroyuki Hosokawa, Akitoshi Nakayama, Naoko Hashimoto, Ikki Sakuma, Hidekazu Nagano, Kazuyuki Yamagata, Fujimi Kudo, Ichiro Manabe, Eunyoung Lee, Ryo Hatano, Atsushi Onodera, Kiyoshi Hirahara, Koutaro Yokote, Takashi Miki, Toshinori Nakayama, Tomoaki Tanaka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Besides hepatocytes, resident immune cells of the liver are also contributing to the body’s energy homeostasis. Here authors show that group 2 innate lymphoid cells interact with a specific set of hepatocytes in suppressing gluconeogenesis and regu
Externí odkaz:
https://doaj.org/article/936a56e77276499ab10f700ad9f26781