Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Tommy Tarvainen"'
1
Effects of block length on the enzymatic degradation and erosion of oxazoline linked poly-ɛ-caprolactone
Autor: Minna Malin, Jukka Seppälä, Kristiina Järvinen, Mika Pulkkinen, Tiina Saarimäki, Tommy Tarvainen
Publikováno v: European Journal of Pharmaceutical Sciences. 31:119-128
The aim of the study was to develop enzyme sensitive polymers for pharmaceutical applications. Thus, 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone (PCL-O) polymers were synthesized by using epsilon-caprolactone precursors with different mole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98647e905158cfc34bf9525fadd98c4e
https://doi.org/10.1016/j.ejps.2007.03.001
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2
Pancreatin enhanced erosion of and macromolecule release from 2,2-bis(2-oxazoline)-linked poly(ϵ-caprolactone)
Autor: Tanja Suutari, Minna Malin, Jukka Tuominen, Kristiina Järvinen, Mikko Pöllänen, Jukka Seppälä, Tommy Tarvainen
Publikováno v: Journal of Controlled Release. 86:213-222
The degradation and erosion of solvent cast films and injection molded bars prepared from poly(epsilon-caprolactone) (PCL) and 2,2'-bis(2-oxazoline) linked poly(epsilon-caprolactone) (PCL-O) were evaluated in simulated gastric fluid (SGF) (pH 1.2, pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58bcfc27a0b9428d73916b2d4d0be14
https://doi.org/10.1016/s0168-3659(02)00372-3
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3
Drug release profiles from and degradation of a novel biodegradable polymer, 2,2-bis(2-oxazoline) linked poly(ε-caprolactone)
Autor: Minna Malin, Jukka Tuominen, Teija Karjalainen, Jukka Seppälä, Kristiina Peräkorpi, Tommy Tarvainen, Kristiina Järvinen
Publikováno v: European Journal of Pharmaceutical Sciences. 16:323-331
In the present study, poly (epsilon -caprolactone) (PCL) was modified by introducing oxamide groups into PCL (PCL-O). The degradation (decrease in molecular weight) and erosion (weight loss) of PCL and PCL-O films were studied in PBS (pH 7.4, USP XXI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc6e69be574623b7fa34260c28eb268
https://doi.org/10.1016/s0928-0987(02)00128-8
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4
Drug release from poly(acrylic acid) grafted poly(vinylidene fluoride) membrane bags in the gastrointestinal tract in the rat and dog
Autor: Bror Svarfvar, Johanna Hyrsylä, Annika Sundell, Timo Nevalainen, Tommy Tarvainen, Petteri Paronen, Kristiina Järvinen
Publikováno v: Journal of Controlled Release. 66:19-26
Stomach-specific drug delivery systems would be of value in treating diseases of the upper gastrointestinal tract. The present study measured in vitro and in vivo drug release from pH-sensitive membrane bags, constructed of poly(acrylic acid) grafted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286a4b1690939f627b828499101c7bd0
https://doi.org/10.1016/s0168-3659(99)00254-0
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6
In vivo implantation of 2,2'-bis(oxazoline)-linked poly-epsilon-caprolactone: proof for enzyme sensitive surface erosion and biocompatibility
Autor: Kristiina Järvinen, Mika Pulkkinen, Jan Böhm, Thomas Wirth, Tommy Tarvainen, Minna Malin, Jukka Seppälä
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 36(2-3)
Previously, we have demonstrated that 2,2-bis(2-oxazoline) linked poly-epsilon-caprolactone (PCL-O) is degraded in vitro enzymatically by surface erosion which could enable the novel use of this material for drug delivery and other biomedical applica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb48698488b21ecc57476e31de960f37
https://pubmed.ncbi.nlm.nih.gov/19022379
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7
Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology: Formulation development and in vitro anticancer activity
Autor: Jukka Seppälä, Thomas Wirth, Vesa Haapa-aho, Harri Korhonen, Tommy Tarvainen, Kristiina Järvinen, Mika Pulkkinen, Jere Pikkarainen
Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 70(1)
Despite recent advances in cancer therapy, many malignant tumors still lack effective treatment and the prognosis is very poor. Paclitaxel is a potential anticancer drug, but its use is limited by the facts that paclitaxel is a P-gp substrate and its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92b55b6db6a88275da726185d0dd32a
https://pubmed.ncbi.nlm.nih.gov/18555675
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8
Effects of incorporated drugs on degradation of novel 2,2'-bis(2-oxazoline) linked poly(lactic acid) films
Autor: Kristiina Järvinen, Minna Malin, Jukka Tuominen, Isabel Barragan, Jukka Seppälä, Tommy Tarvainen
Publikováno v: International journal of pharmaceutics. 310(1-2)
Earlier studies have indicated that the degradation rate of poly(lactic acid) (PDLLA) can be modified by using 2,2'-bis(2-oxazoline) as a chain extender in polymer synthesis to form a lactic acid-based poly(ester-amide) (PEA). In the present study, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199753ea768f970cf69a96baba0e8c97
https://pubmed.ncbi.nlm.nih.gov/16423475
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9
Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer
Autor: Jukka Tuominen, Satu Pohjolainen, Jukka Seppälä, Teija Karjalainen, Tommy Tarvainen, Minna Malin, Kristiina Järvinen
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 81(3)
The degradation rate of poly(lactic acid) (PLA) is typically modified by copolymerization of the glycolide with lactide. In the present study, the degradation rate of PDLLA was modified by a novel linking of PLA with 2,2'-bis(2-oxazoline). This modif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2266d235cf991dd65b273495090f28a1
https://pubmed.ncbi.nlm.nih.gov/12044565
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10
Drug release from cation exchange membrane in rabbit eye
Autor: Tommy Tarvainen, Bror Svarfvar, Marianne Sääskilahti, Petteri Paronen, Kristiina Järvinen, Arto Urtii
Publikováno v: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 15(6)
Cations were adsorbed onto a poly(acrylic acid) (PAA) grafted poly(vinylidene fluoride) (PVDF) membrane that served as a cation exchange membrane. The aim of this study was to evaluate the effect of ionic strength of the adsorption medium on cation r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412e6ff9e8fff43b0ec7469ce8d32a2c
https://pubmed.ncbi.nlm.nih.gov/10609772
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