Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Tommy Nordström"'
Autor:
Muhammad Yasir Asghar, Taru Knuutinen, Emilia Holm, Tommy Nordström, Van Dien Nguyen, You Zhou, Kid Törnquist
Publikováno v:
Cancers, Vol 14, Iss 23, p 5838 (2022)
The thyroid hormone receptor beta 1 (TRβ1) is downregulated in several human cancer cell types, which has been associated with development of an aggressive tumor phenotype and the upregulation of Runt-related transcription factor 2 (Runx2). In this
Externí odkaz:
https://doaj.org/article/2c3bd512580f4ccf86dcbd0ca48cb0d9
Autor:
Susann Björk, Elina A. Ojala, Tommy Nordström, Antti Ahola, Mikko Liljeström, Jari Hyttinen, Esko Kankuri, Eero Mervaala
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes b
Externí odkaz:
https://doaj.org/article/026d58ed550d431a91f0b22c8a7fb594
Publikováno v:
BioTechniques, Vol 26, Iss 4, Pp 728-734 (1999)
A real-time, simple and sensitive method for detection of nucleoside diphosphate (NDP) kinase activity has been developed. The assay is based on detection of ATP, generated in the NDP kinase reaction between a nucleoside triphosphate and adenosine di
Externí odkaz:
https://doaj.org/article/218f38c93a474786ab8733ea4e905a05
Autor:
Jani Lappalainen, Katariina Öörni, Karl E.O. Åkerman, Tommy Nordström, Petri T. Kovanen, Hannele Leinonen, Miriam Lee-Rueckert, Riia Plihtari
Publikováno v:
Atherosclerosis. 312:1-7
Background and aims In focal areas of advanced human atherosclerotic lesions, the intimal fluid is acidic. An acidic medium impairs the ABCA1-mediated cholesterol efflux from macrophages, so tending to increase their content of free cholesterol, whic
Autor:
Tommy Nordström, Lauri Louhivuori, Per Uhlén, Karl E.O. Åkerman, Pauli M. Turunen, Verna Louhivuori, Ibrahim Al Rayyes
Publikováno v:
Stem Cells and Development. 29:1160-1177
Cell-cell communication plays a central role in the guidance of migrating neurons during the development of the cerebral cortex. Neuregulins (NRGs) are essential mediators for migration and maintenance of the radial glial scaffold. We show, in this s
Publikováno v:
Neurochemistry International. 159:105387
Funding Information: Supported by grants from the K. Albin Johansson foundation, the Magnus Ehrnrooth foundation, The Finnish Society of Sciences and Letters and the Medical Society of Finland. We are grateful for the laboratory assistance provided b
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1861:1037-1048
A stroke causes a hypoxic brain microenvironment that alters neural cell metabolism resulting in cell membrane hyperpolarization and intracellular acidosis. We studied how intracellular pH (pH(i)) is regulated in differentiated mouse neural progenito
Publikováno v:
Neuroreport
Self-renewing neural stem cells and progenitor cells are cell populations that generate radial glial cells and neurons through asymmetric division. Regulation of intracellular pH in stem cells with high metabolic activity is critical for both cell si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee6f65c6b925858cdcce05406df7877
http://hdl.handle.net/10138/316972
http://hdl.handle.net/10138/316972
Autor:
Antti Ahola, Eero Mervaala, Tommy Nordström, Esko Kankuri, Susann Björk, Mikko Liljeström, Elina A. Ojala, Jari Hyttinen
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology, Vol 8 (2017)
Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aa2208102f7bc43bad01f6e64a771e
http://hdl.handle.net/10138/228636
http://hdl.handle.net/10138/228636
Autor:
Tommy Nordström, Kari K. Eklund, Petri T. Kovanen, Katariina Öörni, Kristiina Rajamäki, Karl E.O. Åkerman, Katariina Nurmi
Publikováno v:
Journal of Biological Chemistry. 288:13410-13419
Local acidosis has been demonstrated in ischemic tissues and at inflammatory sites.Acidic extracellular pH triggers NLRP3 inflammasome activation and interleukin-1β secretion in human macrophages.Acidic pH represents a novel danger signal alerting t