Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Tommy N. Johansen"'
Publikováno v:
Makedonsko Farmacevtski Bilten, Vol 57, Iss (1, 2), Pp 3-16 (2011)
Ionotropic glutamate receptors (iGluRs) constitute a family of ligand gated ion channels subdivided in three classes, NMDA, AMPA (iGluA1-4) and KA (1-5) according to the agonists that selectively activate them. iGluRs are tetrameric assemblies of hig
Externí odkaz:
https://doaj.org/article/d287df465a054dc0b636ab6f06e5d564
Autor:
Paulina Chałupnik, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Møller, Anders A. Jensen, Birgitte Nielsen, Yasmin Bay, Anders S. Kristensen, Tommy N. Johansen, Kamil Łątka, Marek Bajda, Ewa Szymańska
Publikováno v:
Chałupnik, P, Vialko, A, Pickering, D S, Hinkkanen, M, Donbosco, S, Møller, T C, Jensen, A A, Nielsen, B, Bay, Y, Kristensen, A S, Johansen, T N, Łątka, K, Bajda, M & Szymańska, E 2022, ' Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype ', International Journal of Molecular Sciences, vol. 23, no. 15, 8797 . https://doi.org/10.3390/ijms23158797
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8797
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8797
Kainate receptors belong to the family of glutamate receptors ion channels, which are responsible for the majority of rapid excitatory synaptic transmission in the central nervous system. The therapeutic potential of kainate receptors is still poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c4d39338c6b94fd44885c211955e3
https://curis.ku.dk/portal/da/publications/discovery-of-the-first-highly-selective-antagonist-of-the-gluk3-kainate-receptor-subtype(1dd1c2f0-5aea-4a68-b87c-cdb85b250a93).html
https://curis.ku.dk/portal/da/publications/discovery-of-the-first-highly-selective-antagonist-of-the-gluk3-kainate-receptor-subtype(1dd1c2f0-5aea-4a68-b87c-cdb85b250a93).html
Autor:
Anthony D. Garcia, Kim T. Tran, Lars Jakobsen Høj, Jakob S. Pallesen, Tommy N. Johansen, Giuseppe Marseglia, Michael Gajhede, Federico Munafò, Michael Sattler, Grzegorz M Popowicz, Haritha L. Desu, Dilip Narayanan, Sara Marie Øie Solbak, Anders Bach, Louis M.E. Sørensen, Rosa M. C. Carmona, Roberta Brambilla
Publikováno v:
Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623-4661 . https://doi.org/10.1021/acs.jmedchem.0c02094
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
J. Med. Chem. 64, 4623-4661 (2021)
Journal of Medicinal Chemistry, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623–4661 . https://doi.org/10.1021/acs.jmedchem.0c02094
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
J. Med. Chem. 64, 4623-4661 (2021)
Journal of Medicinal Chemistry, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623–4661 . https://doi.org/10.1021/acs.jmedchem.0c02094
Targeting the protein–protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six
Autor:
Tommy N. Johansen, Anna Więckowska, Ana Maria Cuñado Moral, Birgitte Nielsen, Darryl S. Pickering, Ewa Szymańska, Katarzyna Kieć-Kononowicz, Paulina Chałupnik
Publikováno v:
Chemical Biology & Drug Design. 90:1271-1281
A series of racemic unnatural amino acids was rationally designed on the basis of recently published X-ray structures of the GluA2 LBD with bound phenylalanine-based antagonists. Twelve new diaryl- or aryl/heteroaryl-substituted phenylalanine derivat
Autor:
Jakob Pallesen, Stine Møllerud, Karla Frydenvang, Darryl S. Pickering, Jan Bornholdt, Birgitte Nielsen, Diletta Pasini, Liwei Han, Laura Marconi, Jette Sandholm Kastrup, Tommy N. Johansen
Publikováno v:
ACS chemical neuroscience. 10(3)
Among the ionotropic glutamate receptors, the physiological role of kainate receptors is less well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 are available, tool compounds with selectivity at the remaining
Autor:
Tommy N. Johansen, Birgitte Nielsen, Diletta Pasini, Darryl S. Pickering, Jakob S. Pallesen, Piero Temperini, Karla Frydenvang, Ana V. Paternain, Jette S. Kastrup, Stine Møllerud, Esmira Mamedova, Jesper T. Andreasen, Paulina Chalupnik, Juan Lerma, Rie Bager Hansen, Jan Bornholt, Marta Diaz-delCastillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Selective pharmacological tool compounds are invaluable for understanding the functions of the various ionotropic glutamate receptor subtypes. For the kainate receptors, these compounds are few. Here we have synthesized nine novel quinoxaline-2,3-dio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161de92b3acdb6023d66230679d719f4
http://hdl.handle.net/10261/217920
http://hdl.handle.net/10261/217920
Autor:
Birgitte Nielsen, Katarzyna Kieć-Kononowicz, Katarzyna Szczepańska, Ewa Szymańska, Tommy N. Johansen, Ana Maria Cuñado Moral, Anna Mickowska, Darryl S. Pickering
Publikováno v:
European journal of medicinal chemistry. 138
In order to map out molecular determinants for the competitive blockade of AMPA receptor subtypes, a series of racemic aryl-substituted phenylalanines was synthesized and pharmacologically characterized in vitro at native rat ionotropic glutamate rec
Autor:
Lars Olsen, Liwei Han, Jacob Ingemar Olsen, Ulf Madsen, Niklas Sköld, Tommy N. Johansen, Birgitte Nielsen, Darryl S. Pickering, Jesper L. Kristensen
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:5368-5377
In order to identify compounds selective for the GluK1 and GluK3 subtypes of kainate receptors we have designed and synthesized a series of (S)-2-amino-3-((2-carboxyethyl)phenyl)propanoic acid analogs with hydrogen bond donating and accepting substit
Autor:
Karla Frydenvang, Lars Folke Olsen, Darryl S. Pickering, Birgitte Nielsen, Jette S. Kastrup, Ewa Szymańska, Tommy N. Johansen, Christian Krintel, Ayesheh Kooshki, Linda G. Zachariassen
Publikováno v:
Journal of medicinal chemistry. 59(1)
A series of racemic aryl-substituted phenylalanines was synthesized and evaluated in vitro at recombinant rat GluA1-3, at GluK1-3, and at native AMPA receptors. The individual enantiomers of two target compounds, (RS)-2-amino-3-(3,4-dichloro-5-(5-hyd
Autor:
Tommy N. Johansen, Jette S. Kastrup, Darryl S. Pickering, Birgitte Nielsen, Alberto Contreras-Sanz, Zorica Serafimoska, Ewa Szymańska, Karla Frydenvang, Elena Frola
Publikováno v:
Journal of Medicinal Chemistry. 54:7289-7298
In order to map out molecular determinants for competitive blockade of AMPA receptor subtypes, a series of 2-carboxyethylphenylalanine derivatives has been synthesized and pharmacologically characterized in vitro. One compound in this series, (RS)-3h