Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Tommy L. Lewis"'
Autor:
Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the a
Externí odkaz:
https://doaj.org/article/4622b875797a4a148a830a6b459942d0
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p
Externí odkaz:
https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102550- (2023)
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://doaj.org/article/81eb975c107342e8860817ab0704bc01
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurons in the brain have a uniquely polarized structure consisting of multiple dendrites and a single axon generated from a cell body. Interestingly, intracellular mitochondria also show strikingly polarized morphologies along the dendrites and axon
Externí odkaz:
https://doaj.org/article/3afc1c19a77c4a019d34ce7b95086868
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calciu
Externí odkaz:
https://doaj.org/article/6011499af941422d9a5a9a83b3117271
Autor:
Tamara Zehnder, Francesco Petrelli, Jennifer Romanos, Eva C. De Oliveira Figueiredo, Tommy L. Lewis, Jr., Nicole Déglon, Franck Polleux, Mirko Santello, Paola Bezzi
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108952- (2021)
Summary: The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in ensuring correct synaptogenesis. We show that mitochondrial biogenesis in developing astrocytes is necessary for coordinating post-natal astrocyte matu
Externí odkaz:
https://doaj.org/article/f1df3debacce4887983091ca5960c352
Autor:
Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis, Franck Polleux, Julien Courchet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders
Externí odkaz:
https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
Autor:
Varuzhan Balasanyan, Kaori Watanabe, William P. Dempsey, Tommy L. Lewis, Jr., Le A. Trinh, Don B. Arnold
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2696-2705 (2017)
Summary: The essential organization of microtubules within neurons has been described; however, less is known about how neuronal actin is arranged and the functional implications of its arrangement. Here, we describe, in live cells, an actin-based st
Externí odkaz:
https://doaj.org/article/2704c6e136eb4ff0b112f82539eca436
Autor:
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis Jr., Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1053-1070 (2016)
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same ti
Externí odkaz:
https://doaj.org/article/5ed8e2bf932447198481e0e69bebd50d
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