Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing.

Autor: Severine Margeridon-Thermet, Sophie Le Pogam, Lewyn Li, Tommy F Liu, Nancy Shulman, Robert W Shafer, Isabel Najera

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105569 (2014)

Hepatitis C virus (HCV) variants that confer resistance to direct-acting-antiviral agents (DAA) have been detected by standard sequencing technology in genotype (G) 1 viruses from DAA-naive patients. It has recently been shown that virological respon

Externí odkaz: https://doaj.org/article/c67099558ba645a4bc5adaefcca5165e

Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.

Autor: Diane E Bennett, Ricardo J Camacho, Dan Otelea, Daniel R Kuritzkes, Hervé Fleury, Mark Kiuchi, Walid Heneine, Rami Kantor, Michael R Jordan, Jonathan M Schapiro, Anne-Mieke Vandamme, Paul Sandstrom, Charles A B Boucher, David van de Vijver, Soo-Yon Rhee, Tommy F Liu, Deenan Pillay, Robert W Shafer

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4724 (2009)

Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resista

Externí odkaz: https://doaj.org/article/642a5b90af5e447c9d432be09db7e287

Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

Autor: Gregory K. Robbins, Kristin Razzeca, William J. Towner, Robert W. Shafer, Paolo Troia, Ron M. Kagan, Dennis Israelski, Vici Varghese, George L. Melikian, W. Jeffrey Fessel, Jonathan Taylor, Edwin DeJesus, Soo-Yon Rhee, Jeffrey Burack, Kirsten L. White, Tommy F. Liu, Danielle Porter

Publikováno v: Melikian, GL; Rhee, SY; Varghese, V; Porter, D; White, K; Taylor, J; et al.(2014). Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: Implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing. Journal of Antimicrobial Chemotherapy, 69(1), 12-20. doi: 10.1093/jac/dkt316. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5gg44402
The Journal of antimicrobial chemotherapy, vol 69, iss 1

Objectives: The introduction of two new non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the past 5 years and the identification of novel NNRTI-associated mutations have made it necessary to reassess the extent of phenotypic NNRTI cross-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cba0ba19f23d521cda10580f36b1d88
https://doi.org/10.1093/jac/dkt316

Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment

Autor: Susan Holmes, Robert W. Shafer, Elizabeth C. Reuman, Mary E. Pacold, Tommy F. Liu, Severine Margeridon-Thermet, Ross Martin, Katyna Borroto-Esoda, Evguenia S. Svarovskaia, Farbod Babrzadeh

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:343-349

We sought to determine the prevalence of hepatitis B virus (HBV) lamivudine (LAM)-resistant minority variants in subjects who once received LAM but had discontinued it prior to virus sampling. We performed direct PCR Sanger sequencing and ultradeep p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dbbdf39cc36ed7eecd8a9a4e6dcde2
https://doi.org/10.1128/aac.01601-12

The HIVdb System for HIV-1 Genotypic Resistance Interpretation

Autor: Tommy F. Liu, Robert W. Shafer, Michele W. Tang

Publikováno v: Intervirology. 55:98-101

The Stanford HIV Drug Resistance Database hosts a freely available online genotypic resistance interpretation system called HIVdb to help clinicians and laboratories interpret HIV-1 genotypic resistance tests. These tests are designed to assess susce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a40bb1b333b017cd1d8491893cd434
https://doi.org/10.1159/000331998