Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Tommy Alain"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-13 (2024)
Abstract Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling. The combination of SMCs with immunotherapies
Externí odkaz:
https://doaj.org/article/e7dfa93325ff4ad39a2ad7f101b6277c
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Autor:
Sarah E. Cummings, Sean P. Delaney, Frederic St-Denis Bissonnette, Andrew Stalker, Gauri Muradia, Jelica Mehic, Tyson E. Graber, Tommy Alain, Jessie R. Lavoie
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108708- (2024)
Summary: Extracellular vesicles (EVs) are entering the clinical arena as novel biologics for infectious diseases, potentially serving as the immunogenic components of next generation vaccines. However, relevant human assays to evaluate the immunogeni
Externí odkaz:
https://doaj.org/article/46998e4c994a4f13a53d86c66f5bea2f
Autor:
Akram Alwithenani, Rozanne Arulanandam, Boaz Wong, Marcus M. Spinelli, Andrew Chen, Glib Maznyi, Victoria H. Gilchrist, Tommy Alain, Jean-Simon Diallo
Publikováno v:
Viruses, Vol 16, Iss 6, p 920 (2024)
Oncolytic virotherapy, using viruses such as vesicular stomatitis virus (VSVΔ51) and Herpes Simplex Virus-1 (HSV-1) to selectively attack cancer cells, faces challenges such as cellular resistance mediated by the interferon (IFN) response. Dimethyl
Externí odkaz:
https://doaj.org/article/e68341392f4b4cbdac032deca9f1be17
Autor:
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe
Externí odkaz:
https://doaj.org/article/ac9b0514948d4425b5c222c2feb15ba2
High-Pressure Delivery of Oncolytic Viruses via Needle-Free Injection Preserves Therapeutic Activity
Autor:
Aida Said, Huy-Dung Hoang, Nathalie Earl, Xiao Xiang, Nadeem Siddiqui, Marceline Côté, Tommy Alain
Publikováno v:
Cancers, Vol 15, Iss 23, p 5655 (2023)
Intratumoural delivery of oncolytic viruses (OVs) to solid tumours is currently performed via multiple percutaneous methods of needle injections (NI). In this study, we investigated the potential use of a novel delivery approach, needle-free injectio
Externí odkaz:
https://doaj.org/article/60149b994acc46fba9e58e57cf37622b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Macrophages undergo swift changes in mRNA abundance upon pathogen invasion. Herein we describe early remodelling of the macrophage transcriptome during infection by amastigotes or promastigotes of Leishmania donovani. Approximately 10–16%
Externí odkaz:
https://doaj.org/article/2de07c19a05349b580e296cb4d8e7cc8
Autor:
Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T Beug, Seyed Mehdi Jafarnejad, Samuel T Workenhe, Tyson E Graber, Tommy Alain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, com
Externí odkaz:
https://doaj.org/article/a6f957f1406d4b8b8ac61e2d28561a27
Autor:
Xiao Xiang, Huy-Dung Hoang, Victoria H. Gilchrist, Stéphanie Langlois, Tommy Alain, Kyle N. Cowan
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-15 (2022)
Abstract Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression. PANX1 upregulation thus represents a prospective new treatment s
Externí odkaz:
https://doaj.org/article/41fb1fb1994e45e6919f3b7ece5e8a26
Autor:
Jong Kyu Woo, Tae-Geuk Kim, Na Yeon Im, Ka-Yeon Son, Minhyeon Cho, Yeo Jin Jeong, Jeong-Im Hong, BoRim Kang, Gansukh Enkhtaivan, Nam-Hyuk Cho, Tommy Alain, Dong Guk Park, Yeon-Sook Lee
Publikováno v:
Cancers, Vol 15, Iss 19, p 4703 (2023)
Myxoma virus (MyxV) is a rabbit-specific poxvirus. However, its ability to selectively target tumor cells has established it as a safe and effective anticancer therapy. To strengthen its preclinical efficacy, transgenes that can prolong cancer cell i
Externí odkaz:
https://doaj.org/article/26010cea9e2a4febafbd6f8211f6f5c3