Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tommy A. Rinkoski"'
Autor:
Sanjib Saha, Jessica M. Skeie, Gregory A. Schmidt, Tim Eggleston, Hanna Shevalye, Christopher S. Sales, Pornpoj Phruttiwanichakun, Apurva Dusane, Matthew G. Field, Tommy A. Rinkoski, Michael P. Fautsch, Keith H. Baratz, Madhuparna Roy, Albert S. Jun, Chandler Pendleton, Aliasger K. Salem, Mark A. Greiner
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103348- (2024)
Fuchs endothelial corneal dystrophy (FECD), the leading indication for corneal transplantation in the U.S., causes loss of corneal endothelial cells (CECs) and corneal edema leading to vision loss. FECD pathogenesis is linked to impaired response to
Externí odkaz:
https://doaj.org/article/a5950d340bbe43c3be514fa204657879
Autor:
Gavin W. Roddy, MD, PhD, Darrell Kohli, MD, Parvin Niknam, PhD, Mohammed E. Omer, MBBS, Uttio Roy Chowdhury, PhD, Kjersten J. Anderson, Johann M. Pacheco Marrero, MD, Tommy A. Rinkoski, MS, Michael P. Fautsch, PhD
Publikováno v:
Ophthalmology Science, Vol 5, Iss 1, Pp 100590- (2025)
Purpose: To investigate subconjunctival administration of a single-stranded, adeno-associated virus, serotype 2, engineered to express stanniocalcin-1 with a FLAG tag (ssAAV2-STC-1-FLAG) as a novel sustained (IOP) lowering agent with a reduced ocular
Externí odkaz:
https://doaj.org/article/616071c62b0c48ce82e846e55dd5e155
Autor:
Gavin W. Roddy, Uttio Roy Chowdhury, Kjersten J. Anderson, Tommy A. Rinkoski, Cheryl R. Hann, Vince A. Chiodo, W. Clay Smith, Michael P. Fautsch
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Glaucoma is the leading cause of irreversible blindness worldwide. Therapies for glaucoma are directed toward reducing intraocular pressure (IOP), the leading risk factor and only reliable therapeutic target via topical medications or with procedural
Externí odkaz:
https://doaj.org/article/de3b8256093f4bae8ab204c4ccaf5879
Autor:
Sanjib Saha, Jessica M. Skeie, Gregory A. Schmidt, Tim Eggleston, Hanna Shevalye, Christopher S. Sales, Pornpoj Phruttiwanichakun, Matthew Field, Tommy A. Rinkoski, Michael P. Fautsch, Keith H. Baratz, Madhuparna Roy, Albert S. Jun, Aliasger K. Salem, Mark A. Greiner
Fuchs endothelial corneal dystrophy (FECD), a progressive polygenic disease that causes degeneration of the corneal endothelium, is the leading indication for corneal transplantation in the U.S. Characteristically, loss of corneal endothelial cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884c3b3883abf31a44f955254d4dce2e
https://doi.org/10.1101/2022.06.27.497862
https://doi.org/10.1101/2022.06.27.497862
Autor:
Shubham Basu, Keith H. Baratz, Leo J. Maguire, Sanjay V. Patel, Ross A. Aleff, Michael P. Fautsch, Eric D. Wieben, Tommy A. Rinkoski
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD). Due to limitations in the availability of DNA from diseased corneal endothelium, sizing of CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e45f816725d407a00026866b5f1989
http://europepmc.org/articles/PMC8638873
http://europepmc.org/articles/PMC8638873
Autor:
Meghan M Painter, James H Morrison, Laurie J Zoecklein, Tommy A Rinkoski, Jens O Watzlawik, Louisa M Papke, Arthur E Warrington, Allan J Bieber, William E Matchett, Kari L Turkowski, Eric M Poeschla, Moses Rodriguez
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005311 (2015)
For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible. The innate immune system offers alternative mechanisms that do not requi
Externí odkaz:
https://doaj.org/article/a7744516c8e147598d583085c9739909
Autor:
Michael P. Fautsch, Eric McCloud, Uttio Roy Chowdhury, Cheryl R. Hann, Bradley H. Holman, Cindy K. Bahler, Tommy A. Rinkoski, Peter I. Dosa, Joel M. Reid, Rachel A. Kudgus, Susan E. Appt
Publikováno v:
J Ocul Pharmacol Ther
Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3c997d03d0a608afeb32fe104b8458
https://pubmed.ncbi.nlm.nih.gov/33784195
https://pubmed.ncbi.nlm.nih.gov/33784195
Autor:
Michael P. Fautsch, Eric D. Wieben, Keith H. Baratz, Sanjay V. Patel, Yi-Ju Li, Leo J. Maguire, Tommy A. Rinkoski, Ross A. Aleff, Natalie A. Afshari, William L. Brown, Albert O. Edwards, Timothy T. Xu
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa569a2d4b1430bdbd6a37b556176d5
http://europepmc.org/articles/PMC7814354
http://europepmc.org/articles/PMC7814354
Autor:
Kjersten J. Monson, Gavin W. Roddy, Michael P. Fautsch, Tommy A. Rinkoski, Uttio Roy Chowdhury
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232591 (2020)
PLoS ONE, Vol 15, Iss 5, p e0232591 (2020)
Prostaglandin F2 alpha (PGF2α) analogues such as latanoprost are common first-line intraocular pressure (IOP) lowering medications. However, their clinical use is limited in some patient populations due to minimal or no IOP lowering response or side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a8aa82a9754d8a38f7a815fc46c7e9
http://europepmc.org/articles/PMC7197809
http://europepmc.org/articles/PMC7197809
Autor:
Sanjay V. Patel, Keith H. Baratz, Johann M. Pacheco, Cindy K. Bahler, Leo J. Maguire, David M. Holmes, Eric D. Wieben, Uttio Roy Chowdhury, Tommy A. Rinkoski, Michael P. Fautsch, Maya L. Khanna
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
Primary cultures of human corneal endothelial cells (HCECs) are an important model system for studying the pathophysiology of corneal endothelium. The purpose of this study was to identify and validate an optimal primary culture model of normal and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3750d90b13ee0b6196942b6bf788ede
https://doi.org/10.1371/journal.pone.0258006
https://doi.org/10.1371/journal.pone.0258006