Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tommy A Rinkoski"'
Autor:
Gavin W Roddy, Uttio Roy Chowdhury, Kjersten J Anderson, Tommy A Rinkoski, Cheryl R Hann, Vince A Chiodo, W Clay Smith, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0269261 (2022)
Glaucoma is the leading cause of irreversible blindness worldwide. Therapies for glaucoma are directed toward reducing intraocular pressure (IOP), the leading risk factor and only reliable therapeutic target via topical medications or with procedural
Externí odkaz:
https://doaj.org/article/28159d2c3ef34ea09182ba1e114134c9
Autor:
Tommy A Rinkoski, Cindy K Bahler, Johann M Pacheco, Maya L Khanna, David M Holmes, Uttio Roy Chowdhury, Keith H Baratz, Sanjay V Patel, Leo J Maguire, Eric D Wieben, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0258006 (2021)
Primary cultures of human corneal endothelial cells (HCECs) are an important model system for studying the pathophysiology of corneal endothelium. The purpose of this study was to identify and validate an optimal primary culture model of normal and F
Externí odkaz:
https://doaj.org/article/80d4ea72a60048aca716b4c0b6854e4d
Autor:
Eric D Wieben, Ross A Aleff, Tommy A Rinkoski, Keith H Baratz, Shubham Basu, Sanjay V Patel, Leo J Maguire, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD). Due to limitations in the availability of DNA from diseased corneal endothelium, sizing of CT
Externí odkaz:
https://doaj.org/article/070b8be78a04460c99836328afc01107
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232591 (2020)
Prostaglandin F2 alpha (PGF2α) analogues such as latanoprost are common first-line intraocular pressure (IOP) lowering medications. However, their clinical use is limited in some patient populations due to minimal or no IOP lowering response or side
Externí odkaz:
https://doaj.org/article/76e83251279f4d48908454ec1a8481df
Autor:
Uttio Roy Chowdhury, Rachel A Kudgus, Tommy A Rinkoski, Bradley H Holman, Cindy K Bahler, Cheryl R Hann, Joel M Reid, Peter I Dosa, Michael P Fautsch
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231841 (2020)
Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium
Externí odkaz:
https://doaj.org/article/fa3ee5a25e0c4533837d93f3c27cfe39
Autor:
Meghan M Painter, James H Morrison, Laurie J Zoecklein, Tommy A Rinkoski, Jens O Watzlawik, Louisa M Papke, Arthur E Warrington, Allan J Bieber, William E Matchett, Kari L Turkowski, Eric M Poeschla, Moses Rodriguez
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005311 (2015)
For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible. The innate immune system offers alternative mechanisms that do not requi
Externí odkaz:
https://doaj.org/article/a7744516c8e147598d583085c9739909
Autor:
Sanjib Saha, Jessica M. Skeie, Gregory A. Schmidt, Tim Eggleston, Hanna Shevalye, Christopher S. Sales, Pornpoj Phruttiwanichakun, Matthew Field, Tommy A. Rinkoski, Michael P. Fautsch, Keith H. Baratz, Madhuparna Roy, Albert S. Jun, Aliasger K. Salem, Mark A. Greiner
Fuchs endothelial corneal dystrophy (FECD), a progressive polygenic disease that causes degeneration of the corneal endothelium, is the leading indication for corneal transplantation in the U.S. Characteristically, loss of corneal endothelial cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884c3b3883abf31a44f955254d4dce2e
https://doi.org/10.1101/2022.06.27.497862
https://doi.org/10.1101/2022.06.27.497862
Autor:
Shubham Basu, Keith H. Baratz, Leo J. Maguire, Sanjay V. Patel, Ross A. Aleff, Michael P. Fautsch, Eric D. Wieben, Tommy A. Rinkoski
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260837 (2021)
Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD). Due to limitations in the availability of DNA from diseased corneal endothelium, sizing of CT
Autor:
Michael P. Fautsch, Eric McCloud, Uttio Roy Chowdhury, Cheryl R. Hann, Bradley H. Holman, Cindy K. Bahler, Tommy A. Rinkoski, Peter I. Dosa, Joel M. Reid, Rachel A. Kudgus, Susan E. Appt
Publikováno v:
J Ocul Pharmacol Ther
Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 day
Autor:
Michael P. Fautsch, Eric D. Wieben, Keith H. Baratz, Sanjay V. Patel, Yi-Ju Li, Leo J. Maguire, Tommy A. Rinkoski, Ross A. Aleff, Natalie A. Afshari, William L. Brown, Albert O. Edwards, Timothy T. Xu
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18