Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tommy A Karlsen"'
Autor:
Tommy A Karlsen, Gustavo Antonio de Souza, Bjørn Ødegaard, Lars Engebretsen, Jan E Brinchmann
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Osteoarthritis is a serious disease of articular cartilage. The pathogenic factors contributing to this disorder are inflammation, extracellular matrix degradation and failure to rebuild the articular cartilage. Preclinical studies suggest that micro
Externí odkaz:
https://doaj.org/article/ed0ed5da1c46460d8812b50ef29f75a8
Autor:
Amilton M Fernandes, Sarah R Herlofsen, Tommy A Karlsen, Axel M Küchler, Yngvar Fløisand, Jan E Brinchmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62994 (2013)
Lesions of hyaline cartilage do not heal spontaneously, and represent a therapeutic challenge. In vitro engineering of articular cartilage using cells and biomaterials may prove to be the best solution. Patients with osteoarthritis (OA) may require t
Externí odkaz:
https://doaj.org/article/f3e5029ee0bf4c3fb06385e82c66b014
Autor:
Nadine Frerker, Tommy A. Karlsen, Maria Stensland, Tuula A. Nyman, Simon Rayner, Jan E. Brinchmann
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous cartilage discs may represent the best treatment option
Externí odkaz:
https://doaj.org/article/681900b5c30f4bb4a1d3e8076225004c
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 3, Pp 100189- (2021)
Objective: MicroRNA-140-3p is the most prevalent form of canonical miR-140 in native chondrocytes. IsomiRs are sequence variants of microRNAs with potentially distinct functionalities. Here we present functional studies of canonical microRNA-140-3p a
Externí odkaz:
https://doaj.org/article/9d71648e4f3d437b946812c2370e2215
Autor:
Tommy Frøseth Aae, Tommy Aleksander Karlsen, Ida K. Haugen, May Arna Risberg, Øystein Bjerkestrand Lian, Jan E. Brinchmann
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 1, Iss 3, Pp 100018- (2020)
Summary: Objective: MicroRNAs (miRNAs) are being launched as biomarkers for various diseases, but a robust biomarker for articular cartilage pathology has yet to be discovered. Here we evaluate plasma extracellular vesicle (EV) miRNAs as possible bio
Externí odkaz:
https://doaj.org/article/aca664677ffa4335a0cb74716d333875
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac89d807347efdc9fe2c989c8e4978
http://link.springer.com/article/10.1038/s41598-019-56593-7
http://link.springer.com/article/10.1038/s41598-019-56593-7
Autor:
Asbjørn Årøen, Katherine Wang, Tommy A. Karlsen, Cathrine N. Eftang, Q.Y. Esbensen, C. Owesen, Rune B. Jakobsen
Publikováno v:
Cartilage. 13(1_suppl)
Objective To analyze and compare cartilage samples from 3 groups of patients utilizing low-input RNA-sequencing. Design Cartilage biopsies were collected from patients in 3 groups ( n = 48): Cartilage lesion (CL) patients had at least ICRS grade 2, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9be290b629f6a86a0995351f94968d
https://pubmed.ncbi.nlm.nih.gov/34775802
https://pubmed.ncbi.nlm.nih.gov/34775802
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 3, Pp 100189-(2021)
Objective MicroRNA-140-3p is the most prevalent form of canonical miR-140 in native chondrocytes. IsomiRs are sequence variants of microRNAs with potentially distinct functionalities. Here we present functional studies of canonical microRNA-140-3p an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2b095195870cc5a4bc76b09fa57a18
http://www.sciencedirect.com/science/article/pii/S2665913121000522
http://www.sciencedirect.com/science/article/pii/S2665913121000522
Autor:
Daniela Elena Costea, Pierre Layrolle, Jan E. Brinchmann, Jérôme Amiaud, Kamal Mustafa, Tommy A. Karlsen, Hassan R. W. Ali, Salwa Suliman, Samih Mohamed-Ahmed
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports
Scientific Reports
Therapeutic potential of human bone marrow stromal/stem cells (hBMSC) must be developed using well defined xenogenic-free conditions. hBMSC were isolated from healthy donors (n = 3) using different isolation and expansion methods. Donor I was isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce9ead175f7df267e50a29e1162eefc
http://link.springer.com/article/10.1038/s41598-019-52442-9
http://link.springer.com/article/10.1038/s41598-019-52442-9
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 776-790 (2019)
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 776-790 (2019)
Osteoarthritis (OA) is the most common degenerative joint disease. One of the main pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are dysregulation of microRNAs, reduced autophagic activity, oxidative stress,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c2c5e5906f531a19a624cca26d4b2d
https://doi.org/10.1016/j.omtn.2019.07.011
https://doi.org/10.1016/j.omtn.2019.07.011